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Protein

Thymidine kinase

Gene

TK

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei153Proton acceptorSequence analysis1
Binding sitei184SubstrateBy similarity1
Metal bindingi209ZincBy similarity1
Metal bindingi212ZincBy similarity1
Binding sitei237SubstrateBy similarity1
Metal bindingi241ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 81ATPSequence analysis8
Nucleotide bindingi152 – 155ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
Ordered Locus Names:Os03g0113100, LOC_Os03g02200
ORF Names:OSJNBa0090O10.3
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001749521 – 271Thymidine kinaseAdd BLAST271

Proteomic databases

PaxDbiO81263.

Expressioni

Gene expression databases

GenevisibleiO81263. OS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi39947.LOC_Os03g02200.1.

Structurei

3D structure databases

ProteinModelPortaliO81263.
SMRiO81263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.Curated

Phylogenomic databases

eggNOGiKOG3125. Eukaryota.
COG1435. LUCA.
InParanoidiO81263.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O81263-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSLLAASTF LRSGASPLLR PLSRPLPSRL NLSRFGPVRP VSAAAAAADK
60 70 80 90 100
SRGGGGSAME AQPSYPGEIH VIVGPMFAGK TTALLRRVQV EAGTGSRNVA
110 120 130 140 150
LIKSDKDNRY GLDSVVTHDG TKMPCWALPE LSSFQDKLGT EAYDKVDVIG
160 170 180 190 200
IDEAQFFDDL HDFCCKAADR DGKIVVVAGL DGDYKRNKFG SVLDIIPLAD
210 220 230 240 250
SVTKLTARCE LCGRRAFFTL RKTRETKTEL IGGADVYMPV CRQHYLDGQI
260 270
VIEATRIVLD LEKSKVIHAF K
Length:271
Mass (Da):29,456
Last modified:May 16, 2006 - v2
Checksum:i1ABE3C95DB00E8B4
GO
Isoform 2 (identifier: O81263-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-96: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:270
Mass (Da):29,369
Checksum:iB9D6E409F806206B
GO

Sequence cautioni

The sequence AAC31168 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01838996Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134237 Genomic DNA. Translation: AAO17013.1.
AP014959 Genomic DNA. No translation available.
AK066124 mRNA. No translation available.
AK068779 mRNA. No translation available.
AF066050 mRNA. Translation: AAC31168.1. Different initiation.
PIRiT02888.
UniGeneiOs.2298.

Genome annotation databases

EnsemblPlantsiOS03T0113100-01; OS03T0113100-01; OS03G0113100.
GrameneiOS03T0113100-01; OS03T0113100-01; OS03G0113100.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKITH_ORYSJ
AccessioniPrimary (citable) accession number: O81263
Secondary accession number(s): Q8GZX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 16, 2006
Last modified: November 22, 2017
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families