Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

pdh1

Organism
Zea mays (Maize)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.UniRule annotation

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (gpm175), Glucose-6-phosphate 1-dehydrogenase (Zm.67174), Glucose-6-phosphate 1-dehydrogenase (gpm742), Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform, Glucose-6-phosphate 1-dehydrogenase (LOC100383765)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (Zm.506), 6-phosphogluconate dehydrogenase, decarboxylating (Zm.406), 6-phosphogluconate dehydrogenase, decarboxylating (LOC100856973), 6-phosphogluconate dehydrogenase, decarboxylating (pdh2), 6-phosphogluconate dehydrogenase, decarboxylating (pdh1), 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate dehydrogenase, decarboxylating
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051NADPUniRule annotation
Binding sitei105 – 1051SubstrateUniRule annotation
Active sitei186 – 1861Proton acceptorUniRule annotation
Active sitei193 – 1931Proton donorUniRule annotation
Binding sitei194 – 1941SubstrateUniRule annotation
Binding sitei264 – 2641Substrate; via amide nitrogenUniRule annotation
Binding sitei291 – 2911SubstrateUniRule annotation
Binding sitei450 – 4501Substrate; shared with dimeric partnerUniRule annotation
Binding sitei456 – 4561Substrate; shared with dimeric partnerUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADPUniRule annotation
Nucleotide bindingi33 – 353NADPUniRule annotation
Nucleotide bindingi77 – 793NADPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Gluconate utilizationUniRule annotation, Pentose shuntUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylatingUniRule annotation (EC:1.1.1.44UniRule annotation)
Gene namesi
Name:pdh1Imported
OrganismiZea mays (Maize)Imported
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea

PTM / Processingi

Proteomic databases

PaxDbiO81237.
PRIDEiO81237.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi4577.GRMZM2G145715_P01.

Structurei

3D structure databases

ProteinModelPortaliO81237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 4642836PGDInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni131 – 1333Substrate bindingUniRule annotation
Regioni189 – 1902Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the 6-phosphogluconate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2653. Eukaryota.
COG0362. LUCA.
HOGENOMiHOG000255147.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR012284. 6PGD_dom_3.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_Gnd/GntZ.
IPR006115. 6PGDH_NADP-bd.
IPR016040. NAD(P)-bd_dom.
IPR006183. Pgluconate_DH.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
PRINTSiPR00076. 6PGDHDRGNASE.
SMARTiSM01350. 6PGD. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.

Sequencei

Sequence statusi: Complete.

O81237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTRIGLAG LAVMGQNLAL NIAEKGFPIS VYNRTTSKVD ETVQRAKVEG
60 70 80 90 100
NLPVFGFHDP ASFVSSIQKP RVVIMLVKAG APVDQTIATL AAHLDQGDCI
110 120 130 140 150
VDGGNEWYEN TERREKAMEE RGLLYLGMGV SGGEEGARNG PSLMPGGSFE
160 170 180 190 200
AYKYIEDILL KVAAQVPDSG PCVTYIGKGG SGNFVKMVHN GIEYGDMQLI
210 220 230 240 250
AEAYDVLKSV GKLTNSELHQ VFSEWNKGEL LSFLIEITAD IFGIKDDKGE
260 270 280 290 300
GYLVDKVLDK TGMKGTGKWT VQQAAELSVA APTIEASLDS RFLSGLKDER
310 320 330 340 350
VEASKIFQGD YSTGLPVDKA QLIEDVRQAL YASKICSYAQ GMNIIKAKSS
360 370 380 390 400
EKGWGLNLGE LARIWKGGCI IRAIFLDRIK KAYDRNPNLA NLLVDPEFAQ
410 420 430 440 450
EIIDRQAAWR RVVCLAINNG VSTPGMSASL AYFDSYRRDR LPANLVQAQR
460 470 480
DYFGAHTYER VDMPVLSTPR LRETTSALTR YEKV
Length:484
Mass (Da):53,056
Last modified:November 1, 1998 - v1
Checksum:iE0C6A632F63D208F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061837 mRNA. Translation: AAC27702.1.
PIRiT01658.
UniGeneiZm.95269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061837 mRNA. Translation: AAC27702.1.
PIRiT01658.
UniGeneiZm.95269.

3D structure databases

ProteinModelPortaliO81237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4577.GRMZM2G145715_P01.

Proteomic databases

PaxDbiO81237.
PRIDEiO81237.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2653. Eukaryota.
COG0362. LUCA.
HOGENOMiHOG000255147.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR012284. 6PGD_dom_3.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_Gnd/GntZ.
IPR006115. 6PGDH_NADP-bd.
IPR016040. NAD(P)-bd_dom.
IPR006183. Pgluconate_DH.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
PRINTSiPR00076. 6PGDHDRGNASE.
SMARTiSM01350. 6PGD. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO81237_MAIZE
AccessioniPrimary (citable) accession number: O81237
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.