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Protein

Superoxide dismutase [Mn] 1, mitochondrial

Gene

MSD1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Enzyme regulationi

Activated by MTM1.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi55ManganeseBy similarity1
Metal bindingi103ManganeseBy similarity1
Metal bindingi192ManganeseBy similarity1
Metal bindingi196ManganeseBy similarity1

GO - Molecular functioni

  • copper ion binding Source: TAIR
  • metal ion binding Source: TAIR
  • superoxide dismutase activity Source: UniProtKB-EC

GO - Biological processi

  • defense response to bacterium Source: TAIR
  • embryo development ending in seed dormancy Source: TAIR
  • response to salt stress Source: TAIR
  • response to zinc ion Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] 1, mitochondrial (EC:1.15.1.1)
Alternative name(s):
Protein MANGANESE SUPEROXIDE DISMUTASE 1
Short name:
AtMSD1
Protein MATERNAL EFFECT EMBRYO ARREST 33
Gene namesi
Name:MSD1
Synonyms:MEE3, SODA
Ordered Locus Names:At3g10920
ORF Names:F9F8.26
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G10920.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000003289130 – 231Superoxide dismutase [Mn] 1, mitochondrialAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO81235.
PRIDEiO81235.

PTM databases

iPTMnetiO81235.

Expressioni

Inductioni

Induced by salt stress.1 Publication

Gene expression databases

ExpressionAtlasiO81235. baseline and differential.
GenevisibleiO81235. AT.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi3702.AT3G10920.1.

Structurei

Secondary structure

1231
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi40 – 43Combined sources4
Turni44 – 46Combined sources3
Helixi49 – 57Combined sources9
Helixi59 – 80Combined sources22
Helixi83 – 88Combined sources6
Helixi90 – 108Combined sources19
Helixi113 – 115Combined sources3
Turni116 – 118Combined sources3
Helixi123 – 133Combined sources11
Helixi136 – 149Combined sources14
Beta strandi152 – 161Combined sources10
Turni162 – 165Combined sources4
Beta strandi166 – 173Combined sources8
Helixi178 – 181Combined sources4
Beta strandi185 – 192Combined sources8
Helixi195 – 197Combined sources3
Helixi199 – 202Combined sources4
Helixi206 – 212Combined sources7
Helixi213 – 216Combined sources4
Helixi219 – 228Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C7UX-ray1.95A/B/C/D/E/F/G/H30-231[»]
ProteinModelPortaliO81235.
SMRiO81235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0876. Eukaryota.
COG0605. LUCA.
HOGENOMiHOG000013583.
InParanoidiO81235.
KOiK04564.
OMAiDHHGNVG.
OrthoDBiEOG09360K54.
PhylomeDBiO81235.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: O81235-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIRCVASRK TLAGLKETSS RLLRIRGIQT FTLPDLPYDY GALEPAISGE
60 70 80 90 100
IMQIHHQKHH QAYVTNYNNA LEQLDQAVNK GDASTVVKLQ SAIKFNGGGH
110 120 130 140 150
VNHSIFWKNL APSSEGGGEP PKGSLGSAID AHFGSLEGLV KKMSAEGAAV
160 170 180 190 200
QGSGWVWLGL DKELKKLVVD TTANQDPLVT KGGSLVPLVG IDVWEHAYYL
210 220 230
QYKNVRPEYL KNVWKVINWK YASEVYEKEN N
Length:231
Mass (Da):25,444
Last modified:June 20, 2002 - v2
Checksum:i2DBD5560A9E8AD7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169V → F in AAC24832 (PubMed:9765550).Curated1
Sequence conflicti230N → S in AAM62550 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061518 mRNA. Translation: AAC24832.1.
AC009991 Genomic DNA. Translation: AAF01529.1.
CP002686 Genomic DNA. Translation: AEE74977.1.
AY072495 mRNA. Translation: AAL66910.1.
AY059807 mRNA. Translation: AAL24289.1.
AY085319 mRNA. Translation: AAM62550.1.
PIRiPA0012.
T50827.
RefSeqiNP_187703.1. NM_111929.4. [O81235-1]
UniGeneiAt.11023.

Genome annotation databases

EnsemblPlantsiAT3G10920.1; AT3G10920.1; AT3G10920. [O81235-1]
GeneIDi820263.
GrameneiAT3G10920.1; AT3G10920.1; AT3G10920.
KEGGiath:AT3G10920.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061518 mRNA. Translation: AAC24832.1.
AC009991 Genomic DNA. Translation: AAF01529.1.
CP002686 Genomic DNA. Translation: AEE74977.1.
AY072495 mRNA. Translation: AAL66910.1.
AY059807 mRNA. Translation: AAL24289.1.
AY085319 mRNA. Translation: AAM62550.1.
PIRiPA0012.
T50827.
RefSeqiNP_187703.1. NM_111929.4. [O81235-1]
UniGeneiAt.11023.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C7UX-ray1.95A/B/C/D/E/F/G/H30-231[»]
ProteinModelPortaliO81235.
SMRiO81235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G10920.1.

PTM databases

iPTMnetiO81235.

Proteomic databases

PaxDbiO81235.
PRIDEiO81235.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G10920.1; AT3G10920.1; AT3G10920. [O81235-1]
GeneIDi820263.
GrameneiAT3G10920.1; AT3G10920.1; AT3G10920.
KEGGiath:AT3G10920.

Organism-specific databases

TAIRiAT3G10920.

Phylogenomic databases

eggNOGiKOG0876. Eukaryota.
COG0605. LUCA.
HOGENOMiHOG000013583.
InParanoidiO81235.
KOiK04564.
OMAiDHHGNVG.
OrthoDBiEOG09360K54.
PhylomeDBiO81235.

Enzyme and pathway databases

ReactomeiR-ATH-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

PROiO81235.

Gene expression databases

ExpressionAtlasiO81235. baseline and differential.
GenevisibleiO81235. AT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSODM1_ARATH
AccessioniPrimary (citable) accession number: O81235
Secondary accession number(s): Q8LEP0, Q9SRK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 20, 2002
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.