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Protein

Serine/arginine-rich splicing factor RSZ21

Gene

RSZ21

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in intron recognition and spliceosome assembly.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri89 – 106CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: TAIR

Keywordsi

Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-ATH-72163 mRNA Splicing - Major Pathway
R-ATH-72165 mRNA Splicing - Minor Pathway
R-ATH-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor RSZ21
Alternative name(s):
RS-containing zinc finger protein 21
Short name:
At-RSZ21
Short name:
At-RSZp21
Short name:
AtRSZ21
Gene namesi
Name:RSZ21
Synonyms:RSZP21, SRZ21
Ordered Locus Names:At1g23860
ORF Names:T23E23.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G23860
TAIRilocus:2199837 AT1G23860

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004169911 – 187Serine/arginine-rich splicing factor RSZ21Add BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineCombined sources1
Modified residuei132PhosphoserineBy similarity1
Modified residuei134PhosphoserineBy similarity1
Modified residuei140PhosphoserineBy similarity1
Modified residuei146PhosphoserineBy similarity1
Modified residuei159PhosphoserineBy similarity1
Modified residuei181PhosphoserineBy similarity1

Post-translational modificationi

Extensively phosphorylated on serine residues in the RS domain (By similarity). Phosphorylated by AFC2.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO81127
PRIDEiO81127

PTM databases

iPTMnetiO81127

Expressioni

Tissue specificityi

Expressed in roots, leaves, flowers and siliques.1 Publication

Gene expression databases

ExpressionAtlasiO81127 baseline and differential
GenevisibleiO81127 AT

Interactioni

Subunit structurei

Component of the spliceosome. Interacts with SNRNP35, AFC2, CYP59, RS2Z33 and RNU1 (PubMed:10593939, PubMed:12176998, PubMed:15987817, PubMed:16497658, PubMed:9761791). Interacts with MOS14 (PubMed:21738492).6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RNU1Q424044EBI-927172,EBI-1633812

Protein-protein interaction databases

BioGridi24235, 13 interactors
IntActiO81127, 10 interactors
STRINGi3702.AT1G23860.1

Structurei

3D structure databases

ProteinModelPortaliO81127
SMRiO81127
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 73RRMPROSITE-ProRule annotationAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 85Poly-GlyAdd BLAST12
Compositional biasi102 – 180Arg/Ser-rich (RS domain)Add BLAST79

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri89 – 106CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0107 Eukaryota
ENOG4111N8Y LUCA
HOGENOMiHOG000276234
InParanoidiO81127
KOiK12896
OMAiPRVEFSH
OrthoDBiEOG09360O79
PhylomeDBiO81127

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50158 ZF_CCHC, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: O81127-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTRVYVGNLD PRVTERELED EFKAFGVLRN VWVARRPPGY AFLEFDDERD
60 70 80 90 100
ALDAISALDR KNGWRVELSH KDKGGRGGGG GRRGGIEDSK CYECGELGHF
110 120 130 140 150
ARECRRGRGS VRRRSPSPRR RRSPDYGYAR RSISPRGRRS PPRRRSVTPP
160 170 180
RRGRSYSRSP PYRGSRRDSP RRRDSPYGRR SPYANGV
Length:187
Mass (Da):21,537
Last modified:November 1, 1998 - v1
Checksum:iD8706B45A8E78F72
GO
Isoform 2 (identifier: O81127-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-131: Missing.

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:183
Mass (Da):20,990
Checksum:iE56D819E93AD8671
GO
Isoform 3 (identifier: O81127-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-153: Missing.

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:164
Mass (Da):18,870
Checksum:iC54E8DE949F14A23
GO

Sequence cautioni

The sequence AAF87159 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136R → S in CAA05351 (PubMed:10350090).Curated1
Sequence conflicti153 – 155Missing in CAA05351 (PubMed:10350090).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054986128 – 131Missing in isoform 2. Curated4
Alternative sequenceiVSP_054987131 – 153Missing in isoform 3. CuratedAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033587 mRNA Translation: AAD12770.1
AJ002377 mRNA Translation: CAA05351.1
AC002423 Genomic DNA Translation: AAF87159.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE30440.1
CP002684 Genomic DNA Translation: AEE30441.1
CP002684 Genomic DNA Translation: AEE30442.1
CP002684 Genomic DNA Translation: AEE30443.1
AK317576 mRNA Translation: BAH20240.1
PIRiA86373
T51584
T52628
RefSeqiNP_001117342.1, NM_001123870.4 [O81127-3]
NP_001185074.1, NM_001198145.1 [O81127-2]
NP_564208.1, NM_102234.4 [O81127-1]
NP_973901.1, NM_202172.1 [O81127-1]
UniGeneiAt.22803

Genome annotation databases

EnsemblPlantsiAT1G23860.1; AT1G23860.1; AT1G23860 [O81127-1]
AT1G23860.2; AT1G23860.2; AT1G23860 [O81127-1]
AT1G23860.3; AT1G23860.3; AT1G23860 [O81127-3]
AT1G23860.4; AT1G23860.4; AT1G23860 [O81127-2]
GeneIDi838997
GrameneiAT1G23860.1; AT1G23860.1; AT1G23860 [O81127-1]
AT1G23860.2; AT1G23860.2; AT1G23860 [O81127-1]
AT1G23860.3; AT1G23860.3; AT1G23860 [O81127-3]
AT1G23860.4; AT1G23860.4; AT1G23860 [O81127-2]
KEGGiath:AT1G23860

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRSZ21_ARATH
AccessioniPrimary (citable) accession number: O81127
Secondary accession number(s): B3H6W9
, F4I7M9, O23645, Q9LRA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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