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Protein

Laccase-2

Gene

LAC2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products (By similarity). Required for root elongation in dehydration conditions.By similarity1 Publication

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi85Copper 1; type 2By similarity1
Metal bindingi87Copper 2; type 3By similarity1
Metal bindingi130Copper 2; type 3By similarity1
Metal bindingi132Copper 3; type 3By similarity1
Metal bindingi474Copper 4; type 1By similarity1
Metal bindingi477Copper 1; type 2By similarity1
Metal bindingi479Copper 3; type 3By similarity1
Metal bindingi536Copper 3; type 3By similarity1
Metal bindingi537Copper 4; type 1By similarity1
Metal bindingi538Copper 2; type 3By similarity1
Metal bindingi542Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

  • lignin biosynthetic process Source: GO_Central
  • lignin catabolic process Source: UniProtKB-KW
  • response to water deprivation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G29130-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-2 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 2
Diphenol oxidase 2
Urishiol oxidase 2
Gene namesi
Name:LAC2
Ordered Locus Names:At2g29130
ORF Names:T9I4.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G29130.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000028363027 – 573Laccase-2Add BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Glycosylationi242N-linked (GlcNAc...)Sequence analysis1
Glycosylationi283N-linked (GlcNAc...)Sequence analysis1
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Glycosylationi320N-linked (GlcNAc...)Sequence analysis1
Glycosylationi332N-linked (GlcNAc...)Sequence analysis1
Glycosylationi339N-linked (GlcNAc...)Sequence analysis1
Glycosylationi378N-linked (GlcNAc...)Sequence analysis1
Glycosylationi386N-linked (GlcNAc...)Sequence analysis1
Glycosylationi396N-linked (GlcNAc...)Sequence analysis1
Glycosylationi403N-linked (GlcNAc...)Sequence analysis1
Glycosylationi433N-linked (GlcNAc...)Sequence analysis1
Glycosylationi440N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO81081.
PRIDEiO81081.

Expressioni

Tissue specificityi

Ubiquitous and constitutive.2 Publications

Inductioni

By NaCl and 20% PEG.1 Publication

Gene expression databases

GenevisibleiO81081. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G29130.1.

Structurei

3D structure databases

ProteinModelPortaliO81081.
SMRiO81081.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 151Plastocyanin-like 1Add BLAST117
Domaini161 – 314Plastocyanin-like 2Add BLAST154
Domaini423 – 557Plastocyanin-like 3Add BLAST135

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiO81081.
KOiK05909.
OMAiDAHTFNG.
OrthoDBiEOG093606WG.
PhylomeDBiO81081.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O81081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTWVLNYLL VAFLFAISYN IDAASAGITR HYQFDIQLKN ITRLCKTKTI
60 70 80 90 100
VTVNGKFPGP RVTAREGDNL QIKVVNHVSN NISIHWHGIR QLRSGWADGP
110 120 130 140 150
SYVTQCPIRM GQSYVYNFTV TGQRGTLWWH AHIQWMRATV YGPLIILPKL
160 170 180 190 200
HQPYPFPKPY KQVPILFGEW FNADPQAVVQ QALQTGAGPN ASDAHTFNGL
210 220 230 240 250
PGPLYNCSTK DTYKLMVKPG KTYLLRLINA ALNDELFFTI ANHTLTVVEA
260 270 280 290 300
DACYVKPFQT NIVLLGPGQT TNVLLKTKPI YPNATFYMLA RPYFTGQGTI
310 320 330 340 350
DNTTVAGILQ YQHHTKSSKN LSIIKPSLPP INSTSYAANF TKMFRSLASS
360 370 380 390 400
TFPANVPKVV DKQYFFAIGL GTNPCPKNQT CQGPTNTTKF AASINNVSFI
410 420 430 440 450
LPNKTSLLQS YFVGKSKNVF MTDFPTAPII PFNYTGTPPN NTMVSRGTKV
460 470 480 490 500
VVLKYKTTVE LVLQGTSILG IEAHPIHLHG FNFYVVGQGF GNFNPARDPK
510 520 530 540 550
HYNLVDPVER NTINIPSGGW VAIRFLADNP GVWLMHCHIE IHLSWGLTMA
560 570
WVVLDGDLPN QKLLPPPSDF PKC
Length:573
Mass (Da):63,832
Last modified:November 1, 1998 - v1
Checksum:i1FC2D2C5B3D9E64A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005315 Genomic DNA. Translation: AAC33238.1.
CP002685 Genomic DNA. Translation: AEC08215.1.
BX822041 mRNA. No translation available.
PIRiT02743.
RefSeqiNP_180477.1. NM_128470.5.
UniGeneiAt.13041.

Genome annotation databases

EnsemblPlantsiAT2G29130.1; AT2G29130.1; AT2G29130.
GeneIDi817462.
GrameneiAT2G29130.1; AT2G29130.1; AT2G29130.
KEGGiath:AT2G29130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005315 Genomic DNA. Translation: AAC33238.1.
CP002685 Genomic DNA. Translation: AEC08215.1.
BX822041 mRNA. No translation available.
PIRiT02743.
RefSeqiNP_180477.1. NM_128470.5.
UniGeneiAt.13041.

3D structure databases

ProteinModelPortaliO81081.
SMRiO81081.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G29130.1.

Proteomic databases

PaxDbiO81081.
PRIDEiO81081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G29130.1; AT2G29130.1; AT2G29130.
GeneIDi817462.
GrameneiAT2G29130.1; AT2G29130.1; AT2G29130.
KEGGiath:AT2G29130.

Organism-specific databases

TAIRiAT2G29130.

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiO81081.
KOiK05909.
OMAiDAHTFNG.
OrthoDBiEOG093606WG.
PhylomeDBiO81081.

Enzyme and pathway databases

BioCyciARA:AT2G29130-MONOMER.

Miscellaneous databases

PROiO81081.

Gene expression databases

GenevisibleiO81081. AT.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC2_ARATH
AccessioniPrimary (citable) accession number: O81081
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.