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O81081

- LAC2_ARATH

UniProt

O81081 - LAC2_ARATH

Protein

Laccase-2

Gene

LAC2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products By similarity. Required for root elongation in dehydration conditions.By similarity1 Publication

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi85 – 851Copper 1; type 2By similarity
    Metal bindingi87 – 871Copper 2; type 3By similarity
    Metal bindingi130 – 1301Copper 2; type 3By similarity
    Metal bindingi132 – 1321Copper 3; type 3By similarity
    Metal bindingi474 – 4741Copper 4; type 1By similarity
    Metal bindingi477 – 4771Copper 1; type 2By similarity
    Metal bindingi479 – 4791Copper 3; type 3By similarity
    Metal bindingi536 – 5361Copper 3; type 3By similarity
    Metal bindingi537 – 5371Copper 4; type 1By similarity
    Metal bindingi538 – 5381Copper 2; type 3By similarity
    Metal bindingi542 – 5421Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW
    2. response to water deprivation Source: TAIR

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT2G29130-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-2 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 2
    Diphenol oxidase 2
    Urishiol oxidase 2
    Gene namesi
    Name:LAC2
    Ordered Locus Names:At2g29130
    ORF Names:T9I4.21
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G29130.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 573547Laccase-2PRO_0000283630Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi396 – 3961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO81081.
    PRIDEiO81081.

    Expressioni

    Tissue specificityi

    Ubiquitous and constitutive.2 Publications

    Inductioni

    By NaCl and 20% PEG.1 Publication

    Gene expression databases

    GenevestigatoriO81081.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT2G29130.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliO81081.
    SMRiO81081. Positions 30-561.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 151117Plastocyanin-like 1Add
    BLAST
    Domaini161 – 314154Plastocyanin-like 2Add
    BLAST
    Domaini423 – 557135Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    HOGENOMiHOG000241916.
    InParanoidiO81081.
    OMAiDAHTFNG.
    PhylomeDBiO81081.

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    TIGRFAMsiTIGR03389. laccase. 1 hit.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O81081-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTWVLNYLL VAFLFAISYN IDAASAGITR HYQFDIQLKN ITRLCKTKTI    50
    VTVNGKFPGP RVTAREGDNL QIKVVNHVSN NISIHWHGIR QLRSGWADGP 100
    SYVTQCPIRM GQSYVYNFTV TGQRGTLWWH AHIQWMRATV YGPLIILPKL 150
    HQPYPFPKPY KQVPILFGEW FNADPQAVVQ QALQTGAGPN ASDAHTFNGL 200
    PGPLYNCSTK DTYKLMVKPG KTYLLRLINA ALNDELFFTI ANHTLTVVEA 250
    DACYVKPFQT NIVLLGPGQT TNVLLKTKPI YPNATFYMLA RPYFTGQGTI 300
    DNTTVAGILQ YQHHTKSSKN LSIIKPSLPP INSTSYAANF TKMFRSLASS 350
    TFPANVPKVV DKQYFFAIGL GTNPCPKNQT CQGPTNTTKF AASINNVSFI 400
    LPNKTSLLQS YFVGKSKNVF MTDFPTAPII PFNYTGTPPN NTMVSRGTKV 450
    VVLKYKTTVE LVLQGTSILG IEAHPIHLHG FNFYVVGQGF GNFNPARDPK 500
    HYNLVDPVER NTINIPSGGW VAIRFLADNP GVWLMHCHIE IHLSWGLTMA 550
    WVVLDGDLPN QKLLPPPSDF PKC 573
    Length:573
    Mass (Da):63,832
    Last modified:November 1, 1998 - v1
    Checksum:i1FC2D2C5B3D9E64A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005315 Genomic DNA. Translation: AAC33238.1.
    CP002685 Genomic DNA. Translation: AEC08215.1.
    BX822041 mRNA. No translation available.
    PIRiT02743.
    RefSeqiNP_180477.1. NM_128470.4.
    UniGeneiAt.13041.

    Genome annotation databases

    EnsemblPlantsiAT2G29130.1; AT2G29130.1; AT2G29130.
    GeneIDi817462.
    KEGGiath:AT2G29130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005315 Genomic DNA. Translation: AAC33238.1 .
    CP002685 Genomic DNA. Translation: AEC08215.1 .
    BX822041 mRNA. No translation available.
    PIRi T02743.
    RefSeqi NP_180477.1. NM_128470.4.
    UniGenei At.13041.

    3D structure databases

    ProteinModelPortali O81081.
    SMRi O81081. Positions 30-561.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT2G29130.1-P.

    Proteomic databases

    PaxDbi O81081.
    PRIDEi O81081.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G29130.1 ; AT2G29130.1 ; AT2G29130 .
    GeneIDi 817462.
    KEGGi ath:AT2G29130.

    Organism-specific databases

    TAIRi AT2G29130.

    Phylogenomic databases

    eggNOGi COG2132.
    HOGENOMi HOG000241916.
    InParanoidi O81081.
    OMAi DAHTFNG.
    PhylomeDBi O81081.

    Enzyme and pathway databases

    BioCyci ARA:AT2G29130-MONOMER.

    Gene expression databases

    Genevestigatori O81081.

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    TIGRFAMsi TIGR03389. laccase. 1 hit.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
      Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
      Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 509-573.
      Strain: cv. Columbia.
    4. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
      McCaig B.C., Meagher R.B., Dean J.F.D.
      Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
      Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
      J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.

    Entry informationi

    Entry nameiLAC2_ARATH
    AccessioniPrimary (citable) accession number: O81081
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3