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Protein

Laccase-2

Gene

LAC2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products (By similarity). Required for root elongation in dehydration conditions.By similarity1 Publication

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi85Copper 1; type 2By similarity1
Metal bindingi87Copper 2; type 3By similarity1
Metal bindingi130Copper 2; type 3By similarity1
Metal bindingi132Copper 3; type 3By similarity1
Metal bindingi474Copper 4; type 1By similarity1
Metal bindingi477Copper 1; type 2By similarity1
Metal bindingi479Copper 3; type 3By similarity1
Metal bindingi536Copper 3; type 3By similarity1
Metal bindingi537Copper 4; type 1By similarity1
Metal bindingi538Copper 2; type 3By similarity1
Metal bindingi542Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

  • lignin catabolic process Source: UniProtKB-KW
  • response to water deprivation Source: TAIR

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G29130-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-2 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 2
Diphenol oxidase 2
Urishiol oxidase 2
Gene namesi
Name:LAC2
Ordered Locus Names:At2g29130
ORF Names:T9I4.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G29130
TAIRilocus:2066117 AT2G29130

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000028363027 – 573Laccase-2Add BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi403N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO81081
PRIDEiO81081

Expressioni

Tissue specificityi

Ubiquitous and constitutive.2 Publications

Inductioni

By NaCl and 20% PEG.1 Publication

Gene expression databases

ExpressionAtlasiO81081 baseline and differential
GenevisibleiO81081 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G29130.1

Structurei

3D structure databases

ProteinModelPortaliO81081
SMRiO81081
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 151Plastocyanin-like 1Add BLAST117
Domaini161 – 314Plastocyanin-like 2Add BLAST154
Domaini423 – 557Plastocyanin-like 3Add BLAST135

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
HOGENOMiHOG000241916
InParanoidiO81081
KOiK05909
OMAiTLTDMGC
OrthoDBiEOG093606WG
PhylomeDBiO81081

Family and domain databases

CDDicd13849 CuRO_1_LCC_plant, 1 hit
cd13875 CuRO_2_LCC_plant, 1 hit
cd13897 CuRO_3_LCC_plant, 1 hit
Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
IPR034288 CuRO_1_LCC
IPR034285 CuRO_2_LCC
IPR034289 CuRO_3_LCC
IPR017761 Laccase
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 3 hits
TIGRFAMsiTIGR03389 laccase, 1 hit
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 1 hit
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O81081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTWVLNYLL VAFLFAISYN IDAASAGITR HYQFDIQLKN ITRLCKTKTI
60 70 80 90 100
VTVNGKFPGP RVTAREGDNL QIKVVNHVSN NISIHWHGIR QLRSGWADGP
110 120 130 140 150
SYVTQCPIRM GQSYVYNFTV TGQRGTLWWH AHIQWMRATV YGPLIILPKL
160 170 180 190 200
HQPYPFPKPY KQVPILFGEW FNADPQAVVQ QALQTGAGPN ASDAHTFNGL
210 220 230 240 250
PGPLYNCSTK DTYKLMVKPG KTYLLRLINA ALNDELFFTI ANHTLTVVEA
260 270 280 290 300
DACYVKPFQT NIVLLGPGQT TNVLLKTKPI YPNATFYMLA RPYFTGQGTI
310 320 330 340 350
DNTTVAGILQ YQHHTKSSKN LSIIKPSLPP INSTSYAANF TKMFRSLASS
360 370 380 390 400
TFPANVPKVV DKQYFFAIGL GTNPCPKNQT CQGPTNTTKF AASINNVSFI
410 420 430 440 450
LPNKTSLLQS YFVGKSKNVF MTDFPTAPII PFNYTGTPPN NTMVSRGTKV
460 470 480 490 500
VVLKYKTTVE LVLQGTSILG IEAHPIHLHG FNFYVVGQGF GNFNPARDPK
510 520 530 540 550
HYNLVDPVER NTINIPSGGW VAIRFLADNP GVWLMHCHIE IHLSWGLTMA
560 570
WVVLDGDLPN QKLLPPPSDF PKC
Length:573
Mass (Da):63,832
Last modified:November 1, 1998 - v1
Checksum:i1FC2D2C5B3D9E64A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005315 Genomic DNA Translation: AAC33238.1
CP002685 Genomic DNA Translation: AEC08215.1
BX822041 mRNA No translation available.
PIRiT02743
RefSeqiNP_180477.1, NM_128470.5
UniGeneiAt.13041

Genome annotation databases

EnsemblPlantsiAT2G29130.1; AT2G29130.1; AT2G29130
GeneIDi817462
GrameneiAT2G29130.1; AT2G29130.1; AT2G29130
KEGGiath:AT2G29130

Similar proteinsi

Entry informationi

Entry nameiLAC2_ARATH
AccessioniPrimary (citable) accession number: O81081
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health