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O81081

- LAC2_ARATH

UniProt

O81081 - LAC2_ARATH

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Protein

Laccase-2

Gene

LAC2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products (By similarity). Required for root elongation in dehydration conditions.By similarity1 Publication

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi85 – 851Copper 1; type 2By similarity
Metal bindingi87 – 871Copper 2; type 3By similarity
Metal bindingi130 – 1301Copper 2; type 3By similarity
Metal bindingi132 – 1321Copper 3; type 3By similarity
Metal bindingi474 – 4741Copper 4; type 1By similarity
Metal bindingi477 – 4771Copper 1; type 2By similarity
Metal bindingi479 – 4791Copper 3; type 3By similarity
Metal bindingi536 – 5361Copper 3; type 3By similarity
Metal bindingi537 – 5371Copper 4; type 1By similarity
Metal bindingi538 – 5381Copper 2; type 3By similarity
Metal bindingi542 – 5421Copper 4; type 1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
  2. response to water deprivation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G29130-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-2 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 2
Diphenol oxidase 2
Urishiol oxidase 2
Gene namesi
Name:LAC2
Ordered Locus Names:At2g29130
ORF Names:T9I4.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G29130.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 573547Laccase-2PRO_0000283630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi396 – 3961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO81081.
PRIDEiO81081.

Expressioni

Tissue specificityi

Ubiquitous and constitutive.2 Publications

Inductioni

By NaCl and 20% PEG.1 Publication

Gene expression databases

GenevestigatoriO81081.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G29130.1-P.

Structurei

3D structure databases

ProteinModelPortaliO81081.
SMRiO81081. Positions 30-561.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 151117Plastocyanin-like 1Add
BLAST
Domaini161 – 314154Plastocyanin-like 2Add
BLAST
Domaini423 – 557135Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiO81081.
OMAiDAHTFNG.
PhylomeDBiO81081.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O81081-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTWVLNYLL VAFLFAISYN IDAASAGITR HYQFDIQLKN ITRLCKTKTI
60 70 80 90 100
VTVNGKFPGP RVTAREGDNL QIKVVNHVSN NISIHWHGIR QLRSGWADGP
110 120 130 140 150
SYVTQCPIRM GQSYVYNFTV TGQRGTLWWH AHIQWMRATV YGPLIILPKL
160 170 180 190 200
HQPYPFPKPY KQVPILFGEW FNADPQAVVQ QALQTGAGPN ASDAHTFNGL
210 220 230 240 250
PGPLYNCSTK DTYKLMVKPG KTYLLRLINA ALNDELFFTI ANHTLTVVEA
260 270 280 290 300
DACYVKPFQT NIVLLGPGQT TNVLLKTKPI YPNATFYMLA RPYFTGQGTI
310 320 330 340 350
DNTTVAGILQ YQHHTKSSKN LSIIKPSLPP INSTSYAANF TKMFRSLASS
360 370 380 390 400
TFPANVPKVV DKQYFFAIGL GTNPCPKNQT CQGPTNTTKF AASINNVSFI
410 420 430 440 450
LPNKTSLLQS YFVGKSKNVF MTDFPTAPII PFNYTGTPPN NTMVSRGTKV
460 470 480 490 500
VVLKYKTTVE LVLQGTSILG IEAHPIHLHG FNFYVVGQGF GNFNPARDPK
510 520 530 540 550
HYNLVDPVER NTINIPSGGW VAIRFLADNP GVWLMHCHIE IHLSWGLTMA
560 570
WVVLDGDLPN QKLLPPPSDF PKC
Length:573
Mass (Da):63,832
Last modified:November 1, 1998 - v1
Checksum:i1FC2D2C5B3D9E64A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC005315 Genomic DNA. Translation: AAC33238.1.
CP002685 Genomic DNA. Translation: AEC08215.1.
BX822041 mRNA. No translation available.
PIRiT02743.
RefSeqiNP_180477.1. NM_128470.4.
UniGeneiAt.13041.

Genome annotation databases

EnsemblPlantsiAT2G29130.1; AT2G29130.1; AT2G29130.
GeneIDi817462.
KEGGiath:AT2G29130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC005315 Genomic DNA. Translation: AAC33238.1 .
CP002685 Genomic DNA. Translation: AEC08215.1 .
BX822041 mRNA. No translation available.
PIRi T02743.
RefSeqi NP_180477.1. NM_128470.4.
UniGenei At.13041.

3D structure databases

ProteinModelPortali O81081.
SMRi O81081. Positions 30-561.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT2G29130.1-P.

Proteomic databases

PaxDbi O81081.
PRIDEi O81081.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G29130.1 ; AT2G29130.1 ; AT2G29130 .
GeneIDi 817462.
KEGGi ath:AT2G29130.

Organism-specific databases

TAIRi AT2G29130.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi O81081.
OMAi DAHTFNG.
PhylomeDBi O81081.

Enzyme and pathway databases

BioCyci ARA:AT2G29130-MONOMER.

Gene expression databases

Genevestigatori O81081.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
    Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
    Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 509-573.
    Strain: cv. Columbia.
  4. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
    McCaig B.C., Meagher R.B., Dean J.F.D.
    Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiLAC2_ARATH
AccessioniPrimary (citable) accession number: O81081
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3