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Protein

Abscisic acid 8'-hydroxylase 2

Gene

CYP707A2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the oxidative degradation of abscisic acid, but not in the isomerization of the produced 8'-hydroxyabscisic acid (8'-OH-ABA) to (-)-phaseic acid (PA). Involved in the control of seed dormancy and germination.2 Publications

Catalytic activityi

+-abscisate + NADPH + O2 = 8'-hydroxyabscisate + NADP+ + H2O.

Cofactori

hemeBy similarity

Pathwayi: abscisic acid degradation

This protein is involved in the pathway abscisic acid degradation, which is part of Plant hormone degradation.
View all proteins of this organism that are known to be involved in the pathway abscisic acid degradation and in Plant hormone degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi431Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • (+)-abscisic acid 8'-hydroxylase activity Source: TAIR
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro

GO - Biological processi

  • abscisic acid catabolic process Source: UniProtKB-UniPathway
  • abscisic acid metabolic process Source: TAIR
  • brassinosteroid biosynthetic process Source: GO_Central
  • brassinosteroid homeostasis Source: GO_Central
  • release of seed from dormancy Source: TAIR
  • response to red light Source: TAIR
  • response to red or far red light Source: TAIR
  • sterol metabolic process Source: GO_Central

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processStress response
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BioCyciARA:AT2G29090-MONOMER
MetaCyc:AT2G29090-MONOMER
BRENDAi1.14.13.93 399
ReactomeiR-ATH-211916 Vitamins
R-ATH-5365859 RA biosynthesis pathway
UniPathwayiUPA00093

Names & Taxonomyi

Protein namesi
Recommended name:
Abscisic acid 8'-hydroxylase 2 (EC:1.14.13.93)
Short name:
ABA 8'-hydroxylase 2
Alternative name(s):
Cytochrome P450 707A2
Gene namesi
Name:CYP707A2
Ordered Locus Names:At2g29090
ORF Names:T9I4.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G29090
TAIRilocus:2066138 AT2G29090

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Plants show a hyperdormancy phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002886401 – 482Abscisic acid 8'-hydroxylase 2Add BLAST482

Proteomic databases

PaxDbiO81077

Expressioni

Tissue specificityi

Mainly expressed in dry seeds. Lower expression in rosette leaves, flowers, siliques and stems. Not expressed in roots. Expressed in both endosperm and vascular tissues of embryo during the seed development and in cortex and endodermis in germinating embryo.2 Publications

Developmental stagei

Up-regulated from late-maturation to mature dry seed. Up-regulated immediately after seed imbibition, reaching a maximum at 6 hours and decreasing therafter.2 Publications

Inductioni

By abscisic acid, dehydration and rehydration. Expression regulated by phytochrome B.2 Publications

Gene expression databases

ExpressionAtlasiO81077 baseline and differential
GenevisibleiO81077 AT

Interactioni

Protein-protein interaction databases

BioGridi2807, 13 interactors
STRINGi3702.AT2G29090.1

Structurei

3D structure databases

ProteinModelPortaliO81077
SMRiO81077
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 9Poly-Ser6

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
HOGENOMiHOG000237614
KOiK09843
OMAiRISWEDT
OrthoDBiEOG09360BO8
PhylomeDBiO81077

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

O81077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQISSSSSSN FFSSLYADEP ALITLTIVVV VVVLLFKWWL HWKEQRLRLP
60 70 80 90 100
PGSMGLPYIG ETLRLYTENP NSFFATRQNK YGDIFKTHIL GCPCVMISSP
110 120 130 140 150
EAARMVLVSK AHLFKPTYPP SKERMIGPEA LFFHQGPYHS TLKRLVQSSF
160 170 180 190 200
MPSALRPTVS HIELLVLQTL SSWTSQKSIN TLEYMKRYAF DVAIMSAFGD
210 220 230 240 250
KEEPTTIDVI KLLYQRLERG YNSMPLDLPG TLFHKSMKAR IELSEELRKV
260 270 280 290 300
IEKRRENGRE EGGLLGVLLG AKDQKRNGLS DSQIADNIIG VIFAATDTTA
310 320 330 340 350
SVLTWLLKYL HDHPNLLQEV SREQFSIRQK IKKENRRISW EDTRKMPLTT
360 370 380 390 400
RVIQETLRAA SVLSFTFREA VQDVEYDGYL IPKGWKVLPL FRRIHHSSEF
410 420 430 440 450
FPDPEKFDPS RFEVAPKPYT YMPFGNGVHS CPGSELAKLE MLILLHHLTT
460 470 480
SFRWEVIGDE EGIQYGPFPV PKKGLPIRVT PI
Length:482
Mass (Da):55,176
Last modified:November 1, 1998 - v1
Checksum:iAB6A07AB2778DD3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005315 Genomic DNA Translation: AAC33235.1
CP002685 Genomic DNA Translation: AEC08209.1
CP002685 Genomic DNA Translation: AEC08210.1
AK230466 mRNA Translation: BAF02260.1
PIRiT02739
RefSeqiNP_001189629.1, NM_001202700.1
NP_180473.1, NM_128466.4
UniGeneiAt.50108

Genome annotation databases

EnsemblPlantsiAT2G29090.1; AT2G29090.1; AT2G29090
AT2G29090.2; AT2G29090.2; AT2G29090
GeneIDi817457
GrameneiAT2G29090.1; AT2G29090.1; AT2G29090
AT2G29090.2; AT2G29090.2; AT2G29090
KEGGiath:AT2G29090

Similar proteinsi

Entry informationi

Entry nameiABAH2_ARATH
AccessioniPrimary (citable) accession number: O81077
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health