Reviewed,
UniProtKB/Swiss-Prot O81014 (ISPE_ARATH)
Last modified
November 3, 2009.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic EC=2.7.1.148 Alternative name(s): 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase Short name=CDPMEK Short name=CMK | ||||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 383 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. |
| Catalytic activity | ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. |
| Pathway | |
| Subcellular location | Plastid › chloroplast By similarity. |
| Sequence similarities | Belongs to the GHMP kinase family. IspE subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Isoprene biosynthesis |
| Cellular component | Chloroplast Plastid |
| Domain | Transit peptide |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | phosphorylation Inferred from electronic annotation. Source: InterPro terpenoid biosynthetic processInferred from electronic annotation. Source: InterPro |
| Cellular component | chloroplast Inferred from direct assay. Source: TAIR |
| Molecular function | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Inferred from electronic annotation. Source: EC ATP bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 72 | 72 | Chloroplast Potential | ||||||
| Chain | 73 – 383 | 311 | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic | PRO_0000016479 | |||||
Regions | |||||||||
| Nucleotide binding | 165 – 175 | 11 | ATP Potential | ||||||
| Compositional bias | 22 – 28 | 7 | Poly-Ser | ||||||
Experimental info | |||||||||
| Sequence conflict | 11 | 1 | T → A in AAG01340. Ref.2 | ||||||
| Sequence conflict | 109 | 1 | D → G in AAG01340. Ref.2 | ||||||
| Sequence conflict | 272 | 1 | E → K in AAG01340. Ref.2 | ||||||
| Sequence conflict | 346 | 1 | N → D in AAG01340. Ref.2 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AB037877 mRNA. Translation: BAB21593.1. AF288615 mRNA. Translation: AAG01340.1. AC005168 Genomic DNA. Translation: AAC32234.1. AY136394 mRNA. Translation: AAM97060.1. BT000208 mRNA. Translation: AAN15527.1. | |
| IPI | IPI00538430. |
| PIR | T02642. |
| RefSeq | NP_180261.1. |
| UniGene | At.70122 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O81014. |
Proteomic databases | |
| PRIDE | O81014. |
Genome annotation databases | |
| GeneID | 817234. |
| GenomeReviews | Gene locus AT2G26930 in contig CT485783_GR. |
| KEGG | ath:AT2G26930. |
| NMPDR | fig|3702.1.peg.9719. |
Organism-specific databases | |
| TAIR | At2g26930. |
Phylogenomic databases | |
| OMA | HALETIF. |
Enzyme and pathway databases | |
| BRENDA | 2.7.1.148. 302. |
Gene expression databases | |
| ArrayExpress | O81014. |
| Genevestigator | O81014. |
| GermOnline | AT2G26930. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR004424. IspE. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view] |
| Gene3D | G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. |
| PANTHER | PTHR20861:SF2. IspE. 1 hit. |
| Pfam | PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00154. ispE. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ISPE_ARATH | ||||||||
| Accession | Primary (citable) accession number: O81014 Secondary accession number(s): Q9GI18 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


