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Protein

Protein CIA1

Gene

CIA1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe/S proteins.1 Publication

Caution

GO - Biological processi

  • iron-sulfur cluster assembly Source: TAIR

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CIA11 Publication
Alternative name(s):
Cytosolic iron-sulfur protein assembly 11 Publication
Protein EMBRYO DEFECTIVE 13451 Publication
Gene namesi
Name:CIA11 Publication
Synonyms:EMB13451 Publication
Ordered Locus Names:At2g26060Imported
ORF Names:T19L18.13Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G26060
TAIRilocus:2057381 AT2G26060

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality when homozygous.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004335171 – 352Protein CIA1Add BLAST352

Proteomic databases

PaxDbiO80990

Expressioni

Gene expression databases

ExpressionAtlasiO80990 baseline and differential
GenevisibleiO80990 AT

Interactioni

Subunit structurei

Part of a complex composed of AE7, CIA1, MMS19 and NAR1. Interacts with AE7 and NAR1.1 Publication

Protein-protein interaction databases

STRINGi3702.AT2G26060.1

Structurei

3D structure databases

ProteinModelPortaliO80990
SMRiO80990
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 64WD 1Sequence analysisAdd BLAST47
Repeati72 – 111WD 2Sequence analysisAdd BLAST40
Repeati116 – 155WD 3Sequence analysisAdd BLAST40
Repeati161 – 200WD 4Sequence analysisAdd BLAST40
Repeati211 – 250WD 5Sequence analysisAdd BLAST40
Repeati265 – 303WD 6Sequence analysisAdd BLAST39
Repeati315 – 352WD 7Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the WD repeat CIA1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0645 Eukaryota
ENOG410XRMA LUCA
HOGENOMiHOG000208901
InParanoidiO80990
OMAiVWKCVCT
OrthoDBiEOG09360EM2
PhylomeDBiO80990

Family and domain databases

Gene3Di2.130.10.101 hit
HAMAPiMF_03037 ciao1, 1 hit
InterProiView protein in InterPro
IPR028608 CIAO1/Cia1
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19920 PTHR19920, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 6 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O80990-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLMEKNLEL VEIQKLEGHT DRVWSVAWNP VSSHADGVSP ILASCSGDNT
60 70 80 90 100
VRIWEQSSLS RSWTCKTVLE ETHTRTVRSC AWSPSGQLLA TASFDGTTGI
110 120 130 140 150
WKNYGSEFEC ISTLEGHENE VKSVSWNASG SCLATCSRDK SVWIWEVLEG
160 170 180 190 200
NEYDCAAVLT GHTQDVKMVQ WHPTMDVLFS CSYDNTIKVW WSEDDDGEYQ
210 220 230 240 250
CVQTLGESNN GHSSTVWSIS FNAAGDKMVT CSDDLTLKIW GTDIAKMQSG
260 270 280 290 300
EEYAPWIHLC TLSGYHDRTI YSAHWSRDDI IASGAGDNAI RLFVDSKHDS
310 320 330 340 350
VDGPSYNLLL KKNKAHENDV NSVQWSPGEG NRLLASASDD GMVKIWQLAT

KP
Length:352
Mass (Da):39,131
Last modified:June 1, 2002 - v2
Checksum:iDA691BB99CD67E12
GO
Isoform 2 (identifier: O80990-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-337: EGNRLLASA → VREPVACVG
     338-352: Missing.

Note: No experimental confirmation available. Derived from EST data.Curated
Show »
Length:337
Mass (Da):37,459
Checksum:i5DE3C43E8328957D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057803329 – 337EGNRLLASA → VREPVACVG in isoform 2. 9
Alternative sequenceiVSP_057804338 – 352Missing in isoform 2. Add BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004747 Genomic DNA Translation: AAC31230.2
CP002685 Genomic DNA Translation: AEC07790.1
CP002685 Genomic DNA Translation: AEC07791.1
AY093154 mRNA Translation: AAM13153.1
BT003394 mRNA Translation: AAO30057.1
AY085277 mRNA Translation: AAM62509.1
PIRiT02617
RefSeqiNP_001031421.1, NM_001036344.1 [O80990-2]
NP_565615.1, NM_128165.4 [O80990-1]
UniGeneiAt.38940

Genome annotation databases

EnsemblPlantsiAT2G26060.1; AT2G26060.1; AT2G26060 [O80990-1]
AT2G26060.2; AT2G26060.2; AT2G26060 [O80990-2]
GeneIDi817147
GrameneiAT2G26060.1; AT2G26060.1; AT2G26060 [O80990-1]
AT2G26060.2; AT2G26060.2; AT2G26060 [O80990-2]
KEGGiath:AT2G26060

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCIA1_ARATH
AccessioniPrimary (citable) accession number: O80990
Secondary accession number(s): F4ITL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2015
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome