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Protein

Protein CIA1

Gene

CIA1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe/S proteins.1 Publication

GO - Biological processi

  • iron-sulfur cluster assembly Source: TAIR
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CIA11 Publication
Alternative name(s):
Cytosolic iron-sulfur protein assembly 11 Publication
Protein EMBRYO DEFECTIVE 13451 Publication
Gene namesi
Name:CIA11 Publication
Synonyms:EMB13451 Publication
Ordered Locus Names:At2g26060Imported
ORF Names:T19L18.13Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G26060.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality when homozygous.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004335171 – 352Protein CIA1Add BLAST352

Proteomic databases

PaxDbiO80990.

Expressioni

Gene expression databases

ExpressionAtlasiO80990. baseline and differential.
GenevisibleiO80990. AT.

Interactioni

Subunit structurei

Part of a complex composed of AE7, CIA1, MMS19 and NAR1. Interacts with AE7 and NAR1.1 Publication

Protein-protein interaction databases

STRINGi3702.AT2G26060.1.

Structurei

3D structure databases

ProteinModelPortaliO80990.
SMRiO80990.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 64WD 1Sequence analysisAdd BLAST47
Repeati72 – 111WD 2Sequence analysisAdd BLAST40
Repeati116 – 155WD 3Sequence analysisAdd BLAST40
Repeati161 – 200WD 4Sequence analysisAdd BLAST40
Repeati211 – 250WD 5Sequence analysisAdd BLAST40
Repeati265 – 303WD 6Sequence analysisAdd BLAST39
Repeati315 – 352WD 7Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the WD repeat CIA1 family.Curated
Contains 7 WD repeats.Sequence analysis

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0645. Eukaryota.
ENOG410XRMA. LUCA.
HOGENOMiHOG000208901.
InParanoidiO80990.
OMAiWEVAGDD.
OrthoDBiEOG09360EM2.
PhylomeDBiO80990.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
HAMAPiMF_03037. ciao1. 1 hit.
InterProiIPR028608. CIAO1/Cia1.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O80990-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLMEKNLEL VEIQKLEGHT DRVWSVAWNP VSSHADGVSP ILASCSGDNT
60 70 80 90 100
VRIWEQSSLS RSWTCKTVLE ETHTRTVRSC AWSPSGQLLA TASFDGTTGI
110 120 130 140 150
WKNYGSEFEC ISTLEGHENE VKSVSWNASG SCLATCSRDK SVWIWEVLEG
160 170 180 190 200
NEYDCAAVLT GHTQDVKMVQ WHPTMDVLFS CSYDNTIKVW WSEDDDGEYQ
210 220 230 240 250
CVQTLGESNN GHSSTVWSIS FNAAGDKMVT CSDDLTLKIW GTDIAKMQSG
260 270 280 290 300
EEYAPWIHLC TLSGYHDRTI YSAHWSRDDI IASGAGDNAI RLFVDSKHDS
310 320 330 340 350
VDGPSYNLLL KKNKAHENDV NSVQWSPGEG NRLLASASDD GMVKIWQLAT

KP
Length:352
Mass (Da):39,131
Last modified:June 1, 2002 - v2
Checksum:iDA691BB99CD67E12
GO
Isoform 2 (identifier: O80990-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-337: EGNRLLASA → VREPVACVG
     338-352: Missing.

Note: No experimental confirmation available. Derived from EST data.Curated
Show »
Length:337
Mass (Da):37,459
Checksum:i5DE3C43E8328957D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057803329 – 337EGNRLLASA → VREPVACVG in isoform 2. 9
Alternative sequenceiVSP_057804338 – 352Missing in isoform 2. Add BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004747 Genomic DNA. Translation: AAC31230.2.
CP002685 Genomic DNA. Translation: AEC07790.1.
CP002685 Genomic DNA. Translation: AEC07791.1.
AY093154 mRNA. Translation: AAM13153.1.
BT003394 mRNA. Translation: AAO30057.1.
AY085277 mRNA. Translation: AAM62509.1.
PIRiT02617.
RefSeqiNP_001031421.1. NM_001036344.1. [O80990-2]
NP_565615.1. NM_128165.4. [O80990-1]
UniGeneiAt.38940.

Genome annotation databases

EnsemblPlantsiAT2G26060.1; AT2G26060.1; AT2G26060. [O80990-1]
AT2G26060.2; AT2G26060.2; AT2G26060. [O80990-2]
GeneIDi817147.
GrameneiAT2G26060.1; AT2G26060.1; AT2G26060.
AT2G26060.2; AT2G26060.2; AT2G26060.
KEGGiath:AT2G26060.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004747 Genomic DNA. Translation: AAC31230.2.
CP002685 Genomic DNA. Translation: AEC07790.1.
CP002685 Genomic DNA. Translation: AEC07791.1.
AY093154 mRNA. Translation: AAM13153.1.
BT003394 mRNA. Translation: AAO30057.1.
AY085277 mRNA. Translation: AAM62509.1.
PIRiT02617.
RefSeqiNP_001031421.1. NM_001036344.1. [O80990-2]
NP_565615.1. NM_128165.4. [O80990-1]
UniGeneiAt.38940.

3D structure databases

ProteinModelPortaliO80990.
SMRiO80990.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G26060.1.

Proteomic databases

PaxDbiO80990.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G26060.1; AT2G26060.1; AT2G26060. [O80990-1]
AT2G26060.2; AT2G26060.2; AT2G26060. [O80990-2]
GeneIDi817147.
GrameneiAT2G26060.1; AT2G26060.1; AT2G26060.
AT2G26060.2; AT2G26060.2; AT2G26060.
KEGGiath:AT2G26060.

Organism-specific databases

TAIRiAT2G26060.

Phylogenomic databases

eggNOGiKOG0645. Eukaryota.
ENOG410XRMA. LUCA.
HOGENOMiHOG000208901.
InParanoidiO80990.
OMAiWEVAGDD.
OrthoDBiEOG09360EM2.
PhylomeDBiO80990.

Miscellaneous databases

PROiO80990.

Gene expression databases

ExpressionAtlasiO80990. baseline and differential.
GenevisibleiO80990. AT.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
HAMAPiMF_03037. ciao1. 1 hit.
InterProiIPR028608. CIAO1/Cia1.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCIA1_ARATH
AccessioniPrimary (citable) accession number: O80990
Secondary accession number(s): F4ITL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2015
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.