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Protein

Glycine dehydrogenase (decarboxylating) 2, mitochondrial

Gene

GLDP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The glycine decarboxylase (GDC) or glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity).By similarity1 Publication

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.

Cofactori

GO - Molecular functioni

  • ATP binding Source: TAIR
  • glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciARA:AT2G26080-MONOMER
ReactomeiR-ATH-6783984 Glycine degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 2, mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein 2
Glycine decarboxylase 2
Glycine decarboxylase P-protein 2
Short name:
AtGLDP2
Glycine dehydrogenase (aminomethyl-transferring) 2
Gene namesi
Name:GLDP2
Synonyms:GDCSP, GDP2
Ordered Locus Names:At2g26080
ORF Names:T19L18.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G26080
TAIRilocus:2057464 AT2G26080

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

No visible phenotype; due to the redundancy with GLDP1. Gldp1 and gldp2 double mutants have a seedling development arrested at the cotyledon stage even under nonphotorespiratory conditions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 72MitochondrionCuratedAdd BLAST72
ChainiPRO_000001074373 – 1044Glycine dehydrogenase (decarboxylating) 2, mitochondrialAdd BLAST972

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei780N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiO80988
PRIDEiO80988

PTM databases

iPTMnetiO80988
SwissPalmiO80988

Expressioni

Tissue specificityi

Expressed in leaves. Detected in roots, stems, flowers and siliques.1 Publication

Gene expression databases

ExpressionAtlasiO80988 baseline and differential
GenevisibleiO80988 AT

Interactioni

Subunit structurei

Homodimer (By similarity). The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

Protein-protein interaction databases

BioGridi2501, 2 interactors
IntActiO80988, 1 interactor
STRINGi3702.AT2G26080.1

Structurei

3D structure databases

ProteinModelPortaliO80988
SMRiO80988
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2040 Eukaryota
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
InParanoidiO80988
KOiK00281
OMAiIRVQVII
OrthoDBiEOG093601A5
PhylomeDBiO80988

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O80988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERARRLAYR GIVKRLVNET KRHRNGESSL LPTTTVTPSR YVSSVSSFLH
60 70 80 90 100
RRRDVSGSAF TTSGRNQHQT RSISVDALKP SDTFPRRHNS ATPDEQAQMA
110 120 130 140 150
NYCGFDNLNT LIDSTVPKSI RLDSMKFSGI FDEGLTESQM IEHMSDLASK
160 170 180 190 200
NKVFKSFIGM GYYNTHVPPV ILRNIMENPA WYTQYTPYQA EISQGRLESL
210 220 230 240 250
LNYQTVITDL TGLPMSNASL LDEGTAAAEA MAMCNNILKG KKKTFVIASN
260 270 280 290 300
CHPQTIDVCK TRADGFDLKV VTVDIKDVDY SSGDVCGVLV QYPGTEGEVL
310 320 330 340 350
DYGEFVKNAH ANGVKVVMAT DLLALTMLKP PGEFGADIVV GSGQRFGVPM
360 370 380 390 400
GYGGPHAAFL ATSQEYKRMM PGRIIGVSVD SSGKQALRMA MQTREQHIRR
410 420 430 440 450
DKATSNICTA QALLANMTAM YAVYHGPEGL KSIAQRVHGL AGVFALGLKK
460 470 480 490 500
LGTAQVQDLP FFDTVKVTCS DATAIFDVAA KKEINLRLVD SNTITVAFDE
510 520 530 540 550
TTTLDDVDKL FEVFASGKPV QFTAESLAPE FNNAIPSSLT RESPYLTHPI
560 570 580 590 600
FNMYHTEHEL LRYIHKLQNK DLSLCHSMIP LGSCTMKLNA TTEMMPVTWP
610 620 630 640 650
SFTNMHPFAP VEQAQGYQEM FTNLGELLCT ITGFDSFSLQ PNAGAAGEYA
660 670 680 690 700
GLMVIRAYHM SRGDHHRNVC IIPVSAHGTN PASAAMCGMK IVAVGTDAKG
710 720 730 740 750
NINIEELRNA AEANKDNLAA LMVTYPSTHG VYEEGIDEIC NIIHENGGQV
760 770 780 790 800
YMDGANMNAQ VGLTSPGFIG ADVCHLNLHK TFCIPHGGGG PGMGPIGVKQ
810 820 830 840 850
HLAPFLPSHP VIPTGGIPEP EQTSPLGTIS AAPWGSALIL PISYTYIAMM
860 870 880 890 900
GSGGLTDASK IAILNANYMA KRLESHYPVL FRGVNGTVAH EFIIDLRGFK
910 920 930 940 950
NTAGIEPEDV AKRLMDYGFH GPTMSWPVPG TLMIEPTESE SKAELDRFCD
960 970 980 990 1000
ALISIREEIS QIEKGNADPN NNVLKGAPHP PSLLMADTWK KPYSREYAAF
1010 1020 1030 1040
PAPWLRSSKF WPTTGRVDNV YGDRNLVCTL QPANEEQAAA AVSA
Length:1,044
Mass (Da):113,776
Last modified:November 1, 1998 - v1
Checksum:i227C30B67D82A97D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti534A → T in BAE98954 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004747 Genomic DNA Translation: AAC31228.1
CP002685 Genomic DNA Translation: AEC07793.1
AK226865 mRNA Translation: BAE98954.1
PIRiT02615
RefSeqiNP_180178.1, NM_128167.4
UniGeneiAt.24550
At.72082

Genome annotation databases

EnsemblPlantsiAT2G26080.1; AT2G26080.1; AT2G26080
GeneIDi817149
GrameneiAT2G26080.1; AT2G26080.1; AT2G26080
KEGGiath:AT2G26080

Similar proteinsi

Entry informationi

Entry nameiGCSP2_ARATH
AccessioniPrimary (citable) accession number: O80988
Secondary accession number(s): Q0WV94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health