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O80988

- GCSP2_ARATH

UniProt

O80988 - GCSP2_ARATH

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Protein
Glycine dehydrogenase (decarboxylating) 2, mitochondrial
Gene
GLDP2, GDCSP, GDP2, At2g26080, T19L18.11
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

The glycine decarboxylase (GDC) or glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.1 Publication

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: TAIR
  2. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  3. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciARA:AT2G26080-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 2, mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein 2
Glycine decarboxylase 2
Glycine decarboxylase P-protein 2
Short name:
AtGLDP2
Glycine dehydrogenase (aminomethyl-transferring) 2
Gene namesi
Name:GLDP2
Synonyms:GDCSP, GDP2
Ordered Locus Names:At2g26080
ORF Names:T19L18.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G26080.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. apoplast Source: TAIR
  2. chloroplast Source: TAIR
  3. chloroplast envelope Source: TAIR
  4. mitochondrion Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

No visible phenotype; due to the redundancy with GLDP1. Gldp1 and gldp2 double mutants have a seedling development arrested at the cotyledon stage even under nonphotorespiratory conditions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 7272Mitochondrion Reviewed prediction
Add
BLAST
Chaini73 – 1044972Glycine dehydrogenase (decarboxylating) 2, mitochondrialUniRule annotation
PRO_0000010743Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei780 – 7801N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PaxDbiO80988.
PRIDEiO80988.

Expressioni

Tissue specificityi

Expressed in leaves. Detected in roots, stems, flowers and siliques.1 Publication

Gene expression databases

ArrayExpressiO80988.
GenevestigatoriO80988.

Interactioni

Subunit structurei

Homodimer By similarity. The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

BioGridi2501. 2 interactions.
STRINGi3702.AT2G26080.1-P.

Structurei

3D structure databases

ProteinModelPortaliO80988.
SMRiO80988. Positions 76-1031.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
InParanoidiO80988.
KOiK00281.
OMAiQPANEEQ.
PhylomeDBiO80988.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O80988-1 [UniParc]FASTAAdd to Basket

« Hide

MERARRLAYR GIVKRLVNET KRHRNGESSL LPTTTVTPSR YVSSVSSFLH     50
RRRDVSGSAF TTSGRNQHQT RSISVDALKP SDTFPRRHNS ATPDEQAQMA 100
NYCGFDNLNT LIDSTVPKSI RLDSMKFSGI FDEGLTESQM IEHMSDLASK 150
NKVFKSFIGM GYYNTHVPPV ILRNIMENPA WYTQYTPYQA EISQGRLESL 200
LNYQTVITDL TGLPMSNASL LDEGTAAAEA MAMCNNILKG KKKTFVIASN 250
CHPQTIDVCK TRADGFDLKV VTVDIKDVDY SSGDVCGVLV QYPGTEGEVL 300
DYGEFVKNAH ANGVKVVMAT DLLALTMLKP PGEFGADIVV GSGQRFGVPM 350
GYGGPHAAFL ATSQEYKRMM PGRIIGVSVD SSGKQALRMA MQTREQHIRR 400
DKATSNICTA QALLANMTAM YAVYHGPEGL KSIAQRVHGL AGVFALGLKK 450
LGTAQVQDLP FFDTVKVTCS DATAIFDVAA KKEINLRLVD SNTITVAFDE 500
TTTLDDVDKL FEVFASGKPV QFTAESLAPE FNNAIPSSLT RESPYLTHPI 550
FNMYHTEHEL LRYIHKLQNK DLSLCHSMIP LGSCTMKLNA TTEMMPVTWP 600
SFTNMHPFAP VEQAQGYQEM FTNLGELLCT ITGFDSFSLQ PNAGAAGEYA 650
GLMVIRAYHM SRGDHHRNVC IIPVSAHGTN PASAAMCGMK IVAVGTDAKG 700
NINIEELRNA AEANKDNLAA LMVTYPSTHG VYEEGIDEIC NIIHENGGQV 750
YMDGANMNAQ VGLTSPGFIG ADVCHLNLHK TFCIPHGGGG PGMGPIGVKQ 800
HLAPFLPSHP VIPTGGIPEP EQTSPLGTIS AAPWGSALIL PISYTYIAMM 850
GSGGLTDASK IAILNANYMA KRLESHYPVL FRGVNGTVAH EFIIDLRGFK 900
NTAGIEPEDV AKRLMDYGFH GPTMSWPVPG TLMIEPTESE SKAELDRFCD 950
ALISIREEIS QIEKGNADPN NNVLKGAPHP PSLLMADTWK KPYSREYAAF 1000
PAPWLRSSKF WPTTGRVDNV YGDRNLVCTL QPANEEQAAA AVSA 1044
Length:1,044
Mass (Da):113,776
Last modified:November 1, 1998 - v1
Checksum:i227C30B67D82A97D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti534 – 5341A → T in BAE98954. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004747 Genomic DNA. Translation: AAC31228.1.
CP002685 Genomic DNA. Translation: AEC07793.1.
AK226865 mRNA. Translation: BAE98954.1.
PIRiT02615.
RefSeqiNP_180178.1. NM_128167.3.
UniGeneiAt.24550.
At.72082.

Genome annotation databases

EnsemblPlantsiAT2G26080.1; AT2G26080.1; AT2G26080.
GeneIDi817149.
KEGGiath:AT2G26080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004747 Genomic DNA. Translation: AAC31228.1 .
CP002685 Genomic DNA. Translation: AEC07793.1 .
AK226865 mRNA. Translation: BAE98954.1 .
PIRi T02615.
RefSeqi NP_180178.1. NM_128167.3.
UniGenei At.24550.
At.72082.

3D structure databases

ProteinModelPortali O80988.
SMRi O80988. Positions 76-1031.
ModBasei Search...

Protein-protein interaction databases

BioGridi 2501. 2 interactions.
STRINGi 3702.AT2G26080.1-P.

Proteomic databases

PaxDbi O80988.
PRIDEi O80988.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G26080.1 ; AT2G26080.1 ; AT2G26080 .
GeneIDi 817149.
KEGGi ath:AT2G26080.

Organism-specific databases

GeneFarmi 1741. 130.
TAIRi AT2G26080.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
InParanoidi O80988.
KOi K00281.
OMAi QPANEEQ.
PhylomeDBi O80988.

Enzyme and pathway databases

BioCyci ARA:AT2G26080-MONOMER.

Gene expression databases

ArrayExpressi O80988.
Genevestigatori O80988.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "The glycine decarboxylase system: a fascinating complex."
    Douce R., Bourguignon J., Neuburger M., Rebeille F.
    Trends Plant Sci. 6:167-176(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  5. "Genetic manipulation of glycine decarboxylation."
    Bauwe H., Kolukisaoglu U.
    J. Exp. Bot. 54:1523-1535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, NOMENCLATURE.
  6. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.
  7. "Deletion of glycine decarboxylase in Arabidopsis is lethal under nonphotorespiratory conditions."
    Engel N., van den Daele K., Kolukisaoglu U., Morgenthal K., Weckwerth W., Paernik T., Keerberg O., Bauwe H.
    Plant Physiol. 144:1328-1335(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
    Strain: cv. Columbia and cv. Wassilewskija.

Entry informationi

Entry nameiGCSP2_ARATH
AccessioniPrimary (citable) accession number: O80988
Secondary accession number(s): Q0WV94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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