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Protein

ATP-dependent zinc metalloprotease FTSH 4, mitochondrial

Gene

FTSH4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complex V of the mitochondrial oxidative phosphorylation system.1 Publication

Miscellaneous

In contrast to fungi and metazoa, plant mitochondria have more than one i-AAA-like complexes.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi486Zinc; catalyticBy similarity1
Active sitei487By similarity1
Metal bindingi490Zinc; catalyticBy similarity1
Metal bindingi564Zinc; catalyticBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi267 – 274ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • meristem maintenance Source: TAIR
  • proteolysis Source: GO_Central

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.24.B20 399

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease FTSH 4, mitochondrial (EC:3.4.24.-)
Short name:
AtFTSH4
Gene namesi
Name:FTSH4
Ordered Locus Names:At2g26140
ORF Names:T19L18.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G26140
TAIRilocus:2057386 AT2G26140

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 53Mitochondrion1 PublicationAdd BLAST53
ChainiPRO_000034133054 – 717ATP-dependent zinc metalloprotease FTSH 4, mitochondrialAdd BLAST664

Proteomic databases

PaxDbiO80983
PRIDEiO80983

PTM databases

SwissPalmiO80983

Expressioni

Inductioni

By high light.1 Publication

Gene expression databases

ExpressionAtlasiO80983 baseline and differential
GenevisibleiO80983 AT

Interactioni

Subunit structurei

Homooligomer. The complex formed by FTSH4 does not contain FTSH11.1 Publication

Protein-protein interaction databases

BioGridi2506, 2 interactors
STRINGi3702.AT2G26140.1

Structurei

3D structure databases

ProteinModelPortaliO80983
SMRiO80983
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 44Poly-Gly4
Compositional biasi685 – 707Ala-richAdd BLAST23

Sequence similaritiesi

In the N-terminal section; belongs to the AAA ATPase family.Curated
In the C-terminal section; belongs to the peptidase M41 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0734 Eukaryota
COG0465 LUCA
HOGENOMiHOG000217276
InParanoidiO80983
OMAiCLYRQHS
OrthoDBiEOG093604IN
PhylomeDBiO80983

Family and domain databases

HAMAPiMF_01458 FtsH, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR005936 FtsH
IPR027417 P-loop_NTPase
IPR000642 Peptidase_M41
IPR037219 Peptidase_M41-like
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF01434 Peptidase_M41, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF140990 SSF140990, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01241 FtsH_fam, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O80983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWRRIITKV SSHERELSSL RSLLVRAYSS FPRVGVTGAV GGGGASLPRT
60 70 80 90 100
RFQSSYVGSF ARRVRDREEV NEVAHLRELI RRNDPEAVIR MFESQPSLHA
110 120 130 140 150
NASALSEYIK ALVKVDRLDQ SELVRTLQRG IAGVAREEET FGGLGAFRNV
160 170 180 190 200
GKPTKDGVLG TASAPIHTIS TERTHFKEQL WSTIRTIGVG FLLISGIGAL
210 220 230 240 250
IEDRGIGKGL GLHEEVQPSM DSSTKFSDVK GVDEAKAELE EIVHYLRDPK
260 270 280 290 300
RFTRLGGKLP KGVLLVGPPG TGKTMLARAI AGEAGVPFFS CSGSEFEEMF
310 320 330 340 350
VGVGARRVRD LFSAAKKCSP CIIFIDEIDA IGGSRNPKDQ QYMKMTLNQM
360 370 380 390 400
LVELDGFKQN EGIIVVAATN FPESLDKALV RPGRFDRHIV VPNPDVEGRR
410 420 430 440 450
QILESHMSKV LKAEDVDLMI IARGTPGFSG ADLANLVNVA ALKAAMDGSK
460 470 480 490 500
DVTMSDLEFA KDRIMMGSER KSAVISDESR KLTAFHEGGH ALVAIHTEGA
510 520 530 540 550
LPVHKATIVP RGMALGMVSQ LPDKDETSIS RKQMLARLDV CMGGRVAEEL
560 570 580 590 600
IFGESEVTSG ASSDLEQATK LARAMVTKFG MSKEVGLVAH NYDDNGKSMS
610 620 630 640 650
TETRLLIESE VKQLLEKAYN NAKTILTVYN KELHALANAL LQHETLSGKQ
660 670 680 690 700
IKELLTDLNS PLLQKRQEVV TKQSNPVPPS TPSSASSAAA AAAAAAAAAA
710
AAAATAATKG KDMAPVS
Length:717
Mass (Da):77,275
Last modified:June 1, 2002 - v2
Checksum:iF9110BCB88428CAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004747 Genomic DNA Translation: AAC31223.2
CP002685 Genomic DNA Translation: AEC07799.1
AK220842 mRNA Translation: BAD94171.1
PIRiT02610
RefSeqiNP_565616.1, NM_128172.4
UniGeneiAt.23415

Genome annotation databases

EnsemblPlantsiAT2G26140.1; AT2G26140.1; AT2G26140
GeneIDi817154
GrameneiAT2G26140.1; AT2G26140.1; AT2G26140
KEGGiath:AT2G26140

Similar proteinsi

Entry informationi

Entry nameiFTSH4_ARATH
AccessioniPrimary (citable) accession number: O80983
Secondary accession number(s): Q56ZW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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