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O80939 (LRK41_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-type lectin-domain containing receptor kinase IV.1
Short name=Arabidopsis thaliana lectin-receptor kinase e
Short name=AthlecRK-e
Short name=LecRK-IV.1
EC=2.7.11.1
Alternative name(s):
Lectin Receptor Kinase 1
Gene names
Name:LECRK41
Synonyms:LECRKE, LRK1
Ordered Locus Names:At2g37710
ORF Names:F13M22.21
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length675 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cell membrane; Single-pass type I membrane protein Ref.7 Ref.8.

Sequence similarities

In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

In the N-terminal section; belongs to the leguminous lectin family.

Contains 1 protein kinase domain.

Sequence caution

The sequence CAA65153.1 differs from that shown. Reason: Frameshift at position 634.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 675653L-type lectin-domain containing receptor kinase IV.1
PRO_0000403085

Regions

Topological domain23 – 291269Extracellular Potential
Transmembrane292 – 31221Helical; Potential
Topological domain313 – 675363Cytoplasmic Potential
Domain347 – 624278Protein kinase
Nucleotide binding353 – 3619ATP By similarity
Region25 – 261237Legume-lectin like

Sites

Active site4721Proton acceptor By similarity
Binding site3761ATP By similarity

Amino acid modifications

Modified residue6611Phosphothreonine Ref.8
Glycosylation571N-linked (GlcNAc...) Potential
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation1121N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation1861N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict121Missing in CAA65153. Ref.1
Sequence conflict991I → S in CAA65153. Ref.1
Sequence conflict129 – 1302LA → IT in CAA65153. Ref.1
Sequence conflict299 – 3024LFLI → QFFF in CAA65153. Ref.1
Sequence conflict4821G → R in CAA65153. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O80939 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: C3F2437E6ABA9967

FASTA67575,541
        10         20         30         40         50         60 
MFLKLLTIFF FFFFNLIFQS SSQSLNFAYN NGFNPPTDLS IQGITTVTPN GLLKLTNTTV 

        70         80         90        100        110        120 
QKTGHAFYTK PIRFKDSPNG TVSSFSTSFV FAIHSQIAIL SGHGIAFVVA PNASLPYGNP 

       130        140        150        160        170        180 
SQYIGLFNLA NNGNETNHVF AVELDTILST EFNDTNDNHV GIDINSLKSV QSSPAGYWDE 

       190        200        210        220        230        240 
KGQFKNLTLI SRKPMQVWVD YDGRTNKIDV TMAPFNEDKP TRPLVTAVRD LSSVLLQDMY 

       250        260        270        280        290        300 
VGFSSATGSV LSEHYILGWS FGLNEKAPPL ALSRLPKLPR FEPKRISEFY KIGMPLISLF 

       310        320        330        340        350        360 
LIFSFIFLVC YIVRRRRKFA EELEEWEKEF GKNRFRFKDL YYATKGFKEK GLLGTGGFGS 

       370        380        390        400        410        420 
VYKGVMPGTK LEIAVKRVSH ESRQGMKEFV AEIVSIGRMS HRNLVPLLGY CRRRGELLLV 

       430        440        450        460        470        480 
YDYMPNGSLD KYLYNTPEVT LNWKQRIKVI LGVASGLFYL HEEWEQVVIH RDVKASNVLL 

       490        500        510        520        530        540 
DGELNGRLGD FGLARLYDHG SDPQTTHVVG TLGYLAPEHT RTGRATMATD VFAFGAFLLE 

       550        560        570        580        590        600 
VACGRRPIEF QQETDETFLL VDWVFGLWNK GDILAAKDPN MGSECDEKEV EMVLKLGLLC 

       610        620        630        640        650        660 
SHSDPRARPS MRQVLHYLRG DAKLPELSPL DLSGSGMMFG VHDGFSELGM SYSSSVFKGF 

       670 
TGGSSIADSQ LSGGR

« Hide

References

« Hide 'large scale' references
[1]"A new class of receptor-like protein kinase gene from Arabidopsis thaliana possessing a domain with similarity to plant lectin genes."
Swarup R., Dumas C., Cock J.M.
Plant Gene Register PGR96-022
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Landsberg erecta.
Tissue: Flower.
[2]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"Characterization of the Arabidopsis lecRK-a genes: members of a superfamily encoding putative receptors with an extracellular domain homologous to legume lectins."
Herve C., Serres J., Dabos P., Canut H., Barre A., Rouge P., Lescure B.
Plant Mol. Biol. 39:671-682(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY.
[6]"Lectin receptor kinases in plants."
Barre A., Herve C., Lescure B., Rouge P.
Crit. Rev. Plant Sci. 21:379-399(2002)
Cited for: GENE FAMILY.
[7]"Arabidopsis plasma membrane proteomics identifies components of transport, signal transduction and membrane trafficking."
Alexandersson E., Saalbach G., Larsson C., Kjellbom P.
Plant Cell Physiol. 45:1543-1556(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Strain: cv. Columbia.
Tissue: Leaf and Petiole.
[8]"Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis."
Benschop J.J., Mohammed S., O'Flaherty M., Heck A.J.R., Slijper M., Menke F.L.H.
Mol. Cell. Proteomics 6:1198-1214(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT THR-661, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Strain: cv. Columbia.
[9]"Arabidopsis L-type lectin receptor kinases: phylogeny, classification, and expression profiles."
Bouwmeester K., Govers F.
J. Exp. Bot. 60:4383-4396(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X95909 mRNA. Translation: CAA65153.1. Frameshift.
AC004684 Genomic DNA. Translation: AAC23641.1.
CP002685 Genomic DNA. Translation: AEC09438.1.
AY091070 mRNA. Translation: AAM13890.1.
IPIIPI00548827.
PIRT02537.
T50661.
RefSeqNP_181307.1. NM_129327.3.
UniGeneAt.12798.

3D structure databases

HSSPHSSP built from PDB template 1G9F based on UniProtKB P05046.
ProteinModelPortalO80939.
SMRO80939. Positions 34-262, 324-653.
ModBaseSearch...

Protein-protein interaction databases

STRING3702.AT2G37710.1-P.

Proteomic databases

PaxDbO80939.
PRIDEO80939.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G37710.1; AT2G37710.1; AT2G37710.
GeneID818348.
KEGGath:AT2G37710.

Organism-specific databases

GeneFarm83. 4.
TAIRAt2g37710.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000116555.
InParanoidO80939.
OMAYLAPEHT.
PhylomeDBO80939.
ProtClustDBCLSN2683086.

Gene expression databases

GenevestigatorO80939.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR011009. Kinase-like_dom.
IPR001220. Legume_lectin_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00139. Lectin_legB. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF49899. ConA_like_lec_gl. 1 hit.
SSF56112. Kinase_like. 1 hit.
PROSITEPS00307. LECTIN_LEGUME_BETA. False negative.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLRK41_ARATH
AccessionPrimary (citable) accession number: O80939
Secondary accession number(s): Q39139
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: November 1, 1998
Last modified: May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents