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Protein

ADP-ribosylation factor GTPase-activating protein AGD7

Gene

AGD7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase-activating protein (GAP) for ADP ribosylation factor (ARF). Involved in protein trafficking by controlling ARF1 activity; may participate in COPI vesicle formation at the Golgi complex.1 Publication

Miscellaneous

Plants overexpressing AGD7 show a relocation of proteins from the Golgi complex to the endoplasmic reticulum.

Enzyme regulationi

Activated by binding to phosphatidic acid.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 42C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
Biological processER-Golgi transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-ATH-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor GTPase-activating protein AGD7
Short name:
ARF GAP AGD7
Alternative name(s):
Protein ARF-GAP DOMAIN 7
Short name:
AtAGD7
Protein PDE1 SUPPRESSOR 1
Gene namesi
Name:AGD7
Synonyms:ASP1
Ordered Locus Names:At2g37550
ORF Names:F13M22.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G37550
TAIRilocus:2040691 AT2G37550

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003524991 – 456ADP-ribosylation factor GTPase-activating protein AGD7Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173PhosphoserineBy similarity1
Modified residuei191PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO80925
PRIDEiO80925

PTM databases

iPTMnetiO80925

Expressioni

Tissue specificityi

Expressed in leaves, stems, flower buds and flowers.1 Publication

Gene expression databases

ExpressionAtlasiO80925 baseline and differential
GenevisibleiO80925 AT

Interactioni

Subunit structurei

Interacts with ARF1.1 Publication

Protein-protein interaction databases

BioGridi3675, 1 interactor
STRINGi3702.AT2G37550.1

Structurei

3D structure databases

ProteinModelPortaliO80925
SMRiO80925
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 120Arf-GAPPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi371 – 376Poly-Ser6
Compositional biasi410 – 428Asp-richAdd BLAST19

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 42C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0704 Eukaryota
COG5347 LUCA
HOGENOMiHOG000239963
InParanoidiO80925
KOiK12492
OMAiWQENANN
OrthoDBiEOG09360SAY
PhylomeDBiO80925

Family and domain databases

Gene3Di3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit

Sequencei

Sequence statusi: Complete.

O80925-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAARRLRTL QSQPENKVCV DCSQKNPQWA SISYGIFMCL ECSGKHRGLG
60 70 80 90 100
VHISFVRSVT MDSWSEIQIK KMDAGGNERL NNFLAQYGIS KETDIISKYN
110 120 130 140 150
SNAASVYRDR IQALAEGRQW RDPPIVKESV GGGLMNKKPP LSQGGGRDSG
160 170 180 190 200
NGGWDNWDND DSFRSTDMRR NQSAGDFRSS GGRGAPAKSK SSEDIYSRSQ
210 220 230 240 250
LEASAANKES FFAKRMAENE SKPEGLPPSQ GGKYVGFGSS PGPAPRSNQQ
260 270 280 290 300
SGGGDVFSVM SEGFGRLSLV AASAANVVQT GTMEFTSKVK EGGLDQTVSE
310 320 330 340 350
TVNVVASKTT EIGQRTWGIM KGVMAIASQK VEEFTKEEAS TWNQQNKTEG
360 370 380 390 400
NGYYQNSGIG NKTANSSFGG SQSSSSGHNN SYRNSNSWDD WGEENNSKKE
410 420 430 440 450
AAPKVSTSND DDDGGWAGWD DNDAKDDDFY YQPASDKKSV GHNGKSDTAW

TGGGFL
Length:456
Mass (Da):49,252
Last modified:November 1, 1998 - v1
Checksum:iCCAE49B17B7B7CC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017876 mRNA Translation: BAA75744.1
AC004684 Genomic DNA Translation: AAC23626.1
CP002685 Genomic DNA Translation: AEC09414.1
CP002685 Genomic DNA Translation: AEC09415.1
AY034983 mRNA Translation: AAK59488.1
AF436828 mRNA Translation: AAL32010.1
AY063077 mRNA Translation: AAL34251.1
AY103310 mRNA Translation: AAM65362.1
PIRiT02521
RefSeqiNP_001031503.1, NM_001036426.1
NP_181291.1, NM_129310.3
UniGeneiAt.25553
At.75563

Genome annotation databases

EnsemblPlantsiAT2G37550.1; AT2G37550.1; AT2G37550
AT2G37550.2; AT2G37550.2; AT2G37550
GeneIDi818331
GrameneiAT2G37550.1; AT2G37550.1; AT2G37550
AT2G37550.2; AT2G37550.2; AT2G37550
KEGGiath:AT2G37550

Similar proteinsi

Entry informationi

Entry nameiAGD7_ARATH
AccessioniPrimary (citable) accession number: O80925
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health