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Protein

ADP-ribosylation factor GTPase-activating protein AGD7

Gene

AGD7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein (GAP) for ADP ribosylation factor (ARF). Involved in protein trafficking by controlling ARF1 activity; may participate in COPI vesicle formation at the Golgi complex.1 Publication

Enzyme regulationi

Activated by binding to phosphatidic acid.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 42C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

ER-Golgi transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-ATH-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor GTPase-activating protein AGD7
Short name:
ARF GAP AGD7
Alternative name(s):
Protein ARF-GAP DOMAIN 7
Short name:
AtAGD7
Protein PDE1 SUPPRESSOR 1
Gene namesi
Name:AGD7
Synonyms:ASP1
Ordered Locus Names:At2g37550
ORF Names:F13M22.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G37550.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • Golgi apparatus Source: UniProtKB-SubCell
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003524991 – 456ADP-ribosylation factor GTPase-activating protein AGD7Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173PhosphoserineBy similarity1
Modified residuei191PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO80925.
PRIDEiO80925.

PTM databases

iPTMnetiO80925.

Expressioni

Tissue specificityi

Expressed in leaves, stems, flower buds and flowers.1 Publication

Gene expression databases

GenevisibleiO80925. AT.

Interactioni

Subunit structurei

Interacts with ARF1.1 Publication

Protein-protein interaction databases

BioGridi3675. 1 interactor.
STRINGi3702.AT2G37550.1.

Structurei

3D structure databases

ProteinModelPortaliO80925.
SMRiO80925.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 120Arf-GAPPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi371 – 376Poly-Ser6
Compositional biasi410 – 428Asp-richAdd BLAST19

Sequence similaritiesi

Contains 1 Arf-GAP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 42C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0704. Eukaryota.
COG5347. LUCA.
HOGENOMiHOG000239963.
InParanoidiO80925.
KOiK12492.
OMAiEEASTWN.
OrthoDBiEOG09360SAY.
PhylomeDBiO80925.

Family and domain databases

InterProiIPR001164. ArfGAP.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
[Graphical view]
PROSITEiPS50115. ARFGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O80925-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAARRLRTL QSQPENKVCV DCSQKNPQWA SISYGIFMCL ECSGKHRGLG
60 70 80 90 100
VHISFVRSVT MDSWSEIQIK KMDAGGNERL NNFLAQYGIS KETDIISKYN
110 120 130 140 150
SNAASVYRDR IQALAEGRQW RDPPIVKESV GGGLMNKKPP LSQGGGRDSG
160 170 180 190 200
NGGWDNWDND DSFRSTDMRR NQSAGDFRSS GGRGAPAKSK SSEDIYSRSQ
210 220 230 240 250
LEASAANKES FFAKRMAENE SKPEGLPPSQ GGKYVGFGSS PGPAPRSNQQ
260 270 280 290 300
SGGGDVFSVM SEGFGRLSLV AASAANVVQT GTMEFTSKVK EGGLDQTVSE
310 320 330 340 350
TVNVVASKTT EIGQRTWGIM KGVMAIASQK VEEFTKEEAS TWNQQNKTEG
360 370 380 390 400
NGYYQNSGIG NKTANSSFGG SQSSSSGHNN SYRNSNSWDD WGEENNSKKE
410 420 430 440 450
AAPKVSTSND DDDGGWAGWD DNDAKDDDFY YQPASDKKSV GHNGKSDTAW

TGGGFL
Length:456
Mass (Da):49,252
Last modified:November 1, 1998 - v1
Checksum:iCCAE49B17B7B7CC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017876 mRNA. Translation: BAA75744.1.
AC004684 Genomic DNA. Translation: AAC23626.1.
CP002685 Genomic DNA. Translation: AEC09414.1.
CP002685 Genomic DNA. Translation: AEC09415.1.
AY034983 mRNA. Translation: AAK59488.1.
AF436828 mRNA. Translation: AAL32010.1.
AY063077 mRNA. Translation: AAL34251.1.
AY103310 mRNA. Translation: AAM65362.1.
PIRiT02521.
RefSeqiNP_001031503.1. NM_001036426.1.
NP_181291.1. NM_129310.3.
UniGeneiAt.25553.
At.75563.

Genome annotation databases

EnsemblPlantsiAT2G37550.1; AT2G37550.1; AT2G37550.
AT2G37550.2; AT2G37550.2; AT2G37550.
GeneIDi818331.
GrameneiAT2G37550.1; AT2G37550.1; AT2G37550.
AT2G37550.2; AT2G37550.2; AT2G37550.
KEGGiath:AT2G37550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017876 mRNA. Translation: BAA75744.1.
AC004684 Genomic DNA. Translation: AAC23626.1.
CP002685 Genomic DNA. Translation: AEC09414.1.
CP002685 Genomic DNA. Translation: AEC09415.1.
AY034983 mRNA. Translation: AAK59488.1.
AF436828 mRNA. Translation: AAL32010.1.
AY063077 mRNA. Translation: AAL34251.1.
AY103310 mRNA. Translation: AAM65362.1.
PIRiT02521.
RefSeqiNP_001031503.1. NM_001036426.1.
NP_181291.1. NM_129310.3.
UniGeneiAt.25553.
At.75563.

3D structure databases

ProteinModelPortaliO80925.
SMRiO80925.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi3675. 1 interactor.
STRINGi3702.AT2G37550.1.

PTM databases

iPTMnetiO80925.

Proteomic databases

PaxDbiO80925.
PRIDEiO80925.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G37550.1; AT2G37550.1; AT2G37550.
AT2G37550.2; AT2G37550.2; AT2G37550.
GeneIDi818331.
GrameneiAT2G37550.1; AT2G37550.1; AT2G37550.
AT2G37550.2; AT2G37550.2; AT2G37550.
KEGGiath:AT2G37550.

Organism-specific databases

TAIRiAT2G37550.

Phylogenomic databases

eggNOGiKOG0704. Eukaryota.
COG5347. LUCA.
HOGENOMiHOG000239963.
InParanoidiO80925.
KOiK12492.
OMAiEEASTWN.
OrthoDBiEOG09360SAY.
PhylomeDBiO80925.

Enzyme and pathway databases

ReactomeiR-ATH-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiO80925.

Gene expression databases

GenevisibleiO80925. AT.

Family and domain databases

InterProiIPR001164. ArfGAP.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
[Graphical view]
PROSITEiPS50115. ARFGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGD7_ARATH
AccessioniPrimary (citable) accession number: O80925
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Plants overexpressing AGD7 show a relocation of proteins from the Golgi complex to the endoplasmic reticulum.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.