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Protein

Abscisic acid receptor PYL4

Gene

PYL4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (PubMed:19624469, PubMed:23844015, PubMed:21658606). Can be activated by both (-)-ABA and (+)-ABA (PubMed:23844015).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81ABABy similarity1
Sitei110Involved in interactions with PP2CsBy similarity1
Binding sitei160ABABy similarity1
Sitei171Involved in interactions with PP2CsBy similarity1
Sitei179Involved in ABA bindingBy similarity1

GO - Molecular functioni

  • abscisic acid binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein phosphatase inhibitor activity Source: UniProtKB
  • receptor activity Source: UniProtKB

GO - Biological processi

  • abscisic acid-activated signaling pathway Source: UniProtKB

Keywordsi

Molecular functionProtein phosphatase inhibitor, Receptor
Biological processAbscisic acid signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Abscisic acid receptor PYL4
Alternative name(s):
ABI1-binding protein 2
PYR1-like protein 4
Regulatory components of ABA receptor 10
Gene namesi
Name:PYL4
Synonyms:ABIP2, RCAR10
Ordered Locus Names:At2g38310
ORF Names:T19C21.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G38310
TAIRilocus:2057175 AT2G38310

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003917391 – 207Abscisic acid receptor PYL4Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 176ReversibleBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO80920
PRIDEiO80920

PTM databases

iPTMnetiO80920

Expressioni

Gene expression databases

ExpressionAtlasiO80920 baseline and differential
GenevisibleiO80920 AT

Interactioni

Subunit structurei

Monomer (PubMed:21658606). Homodimer. Binds ABA on one subunit only (By similarity). Interacts with HAB1, ABI1 and ABI2, and possibly with other PP2Cs (PubMed:19407142, PubMed:19874541, PubMed:19898420). Binds to CARs protein in an ABA-independent manner, both at the plasma membrane and in the nucleus. Interacts directly with CAR1 and CAR4 (PubMed:25465408). Interacts with TOPP1 (PubMed:26943172).By similarity6 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi3753, 11 interactors
DIPiDIP-53474N
IntActiO80920, 6 interactors
STRINGi3702.AT2G38310.1

Structurei

3D structure databases

ProteinModelPortaliO80920
SMRiO80920
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 195START-likeAdd BLAST151
Regioni111 – 116ABA bindingBy similarity6
Regioni138 – 144ABA bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi107 – 111Gate loopBy similarity5
Motifi137 – 139Latch loopBy similarity3

Domaini

Upon interaction with ABA, the 'latch' and 'gate' loops change in conformation leading to a tight dimerization and the creation a surface that enables the receptor to dock into and inhibit the PP2C active site.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IG1P Eukaryota
ENOG4111MYF LUCA
HOGENOMiHOG000238422
InParanoidiO80920
KOiK14496
OMAiDQCCSAV
OrthoDBiEOG09360T2Z
PhylomeDBiO80920

Family and domain databases

Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR019587 Polyketide_cyclase/dehydratase
IPR023393 START-like_dom_sf
PfamiView protein in Pfam
PF10604 Polyketide_cyc2, 1 hit

Sequencei

Sequence statusi: Complete.

O80920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAVHRPSSA VSDGDSVQIP MMIASFQKRF PSLSRDSTAA RFHTHEVGPN
60 70 80 90 100
QCCSAVIQEI SAPISTVWSV VRRFDNPQAY KHFLKSCSVI GGDGDNVGSL
110 120 130 140 150
RQVHVVSGLP AASSTERLDI LDDERHVISF SVVGGDHRLS NYRSVTTLHP
160 170 180 190 200
SPISGTVVVE SYVVDVPPGN TKEETCDFVD VIVRCNLQSL AKIAENTAAE

SKKKMSL
Length:207
Mass (Da):22,435
Last modified:November 1, 1998 - v1
Checksum:i118160B35D7066BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004683 Genomic DNA Translation: AAC28773.1
CP002685 Genomic DNA Translation: AEC09522.1
AY039586 mRNA Translation: AAK62641.1
AY054141 mRNA Translation: AAL06802.1
AY087146 mRNA Translation: AAM64704.1
PIRiT02514
RefSeqiNP_565887.1, NM_129387.3
UniGeneiAt.12775

Genome annotation databases

EnsemblPlantsiAT2G38310.1; AT2G38310.1; AT2G38310
GeneIDi818411
GrameneiAT2G38310.1; AT2G38310.1; AT2G38310
KEGGiath:AT2G38310

Similar proteinsi

Entry informationi

Entry nameiPYL4_ARATH
AccessioniPrimary (citable) accession number: O80920
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health