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Protein

Peroxidase 23

Gene

PER23

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei67Transition state stabilizerPROSITE-ProRule annotation1
Active sitei71Proton acceptorPROSITE-ProRule annotation1
Metal bindingi72Calcium 1PROSITE-ProRule annotation1
Metal bindingi75Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi77Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi79Calcium 1PROSITE-ProRule annotation1
Metal bindingi81Calcium 1PROSITE-ProRule annotation1
Binding sitei168Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi199Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi200Calcium 2PROSITE-ProRule annotation1
Metal bindingi251Calcium 2PROSITE-ProRule annotation1
Metal bindingi254Calcium 2PROSITE-ProRule annotation1
Metal bindingi259Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G38390-MONOMER

Protein family/group databases

PeroxiBasei116 AtPrx23

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 23 (EC:1.11.1.7)
Short name:
Atperox P23
Alternative name(s):
ATP34
Gene namesi
Name:PER23
Synonyms:P23
Ordered Locus Names:At2g38390
ORF Names:T19C21.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G38390
TAIRilocus:2057165 AT2G38390

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000002368930 – 349Peroxidase 23Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30Pyrrolidone carboxylic acidPROSITE-ProRule annotationBy similarity1
Disulfide bondi40 ↔ 120PROSITE-ProRule annotation
Disulfide bondi73 ↔ 78PROSITE-ProRule annotation
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi126 ↔ 329PROSITE-ProRule annotation
Disulfide bondi206 ↔ 238PROSITE-ProRule annotation
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiO80912
PRIDEiO80912

Expressioni

Inductioni

By methyl jasmonate, a plant defense-related signaling molecule.1 Publication

Gene expression databases

ExpressionAtlasiO80912 baseline and differential
GenevisibleiO80912 AT

Interactioni

Protein-protein interaction databases

IntActiO80912, 1 interactor
STRINGi3702.AT2G38390.1

Structurei

3D structure databases

ProteinModelPortaliO80912
SMRiO80912
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JT8V Eukaryota
ENOG411082W LUCA
HOGENOMiHOG000237557
InParanoidiO80912
KOiK00430
OMAiCPPIFNI
OrthoDBiEOG09360FST
PhylomeDBiO80912

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O80912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFSSSLSCS AMGALIVGCL LLQASNSNAQ LRPDFYFRTC PPIFNIIGDT
60 70 80 90 100
IVNELRTDPR IAASLLRLHF HDCFVRGCDA SILLDNSTSF RTEKDAAPNK
110 120 130 140 150
NSVRGFDVID RMKAAIERAC PRTVSCADII TIASQISVLL SGGPWWPVPL
160 170 180 190 200
GRRDSVEAFF ALANTALPSP FSTLTQLKTA FADVGLNRPS DLVALSGGHT
210 220 230 240 250
FGKAQCQFVT PRLYNFNGTN RPDPSLNPTY LVELRRLCPQ NGNGTVLVNF
260 270 280 290 300
DSVTPTTFDR QYYTNLLNGK GLIQSDQVLF STPGADTIPL VNQYSSNTFV
310 320 330 340
FFGAFVDAMI RMGNLKPLTG TQGEIRQNCR VVNPRIRVVE NDDGVVSSI
Length:349
Mass (Da):38,100
Last modified:November 1, 1998 - v1
Checksum:i74A1C6F71A415169
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452385 mRNA Translation: AAL40849.1
AC004683 Genomic DNA Translation: AAC28765.1
CP002685 Genomic DNA Translation: AEC09531.1
AY099555 mRNA Translation: AAM20407.1
BT001238 mRNA Translation: AAN65125.1
PIRiT02506
RefSeqiNP_181373.1, NM_129395.3
UniGeneiAt.28466

Genome annotation databases

EnsemblPlantsiAT2G38390.1; AT2G38390.1; AT2G38390
GeneIDi818420
GrameneiAT2G38390.1; AT2G38390.1; AT2G38390
KEGGiath:AT2G38390

Similar proteinsi

Entry informationi

Entry nameiPER23_ARATH
AccessioniPrimary (citable) accession number: O80912
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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