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Protein

CBL-interacting serine/threonine-protein kinase 22

Gene

CIPK22

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei58ATPPROSITE-ProRule annotation1
Active sitei150Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 42ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Manganese, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CBL-interacting serine/threonine-protein kinase 22 (EC:2.7.11.1)
Alternative name(s):
SNF1-related kinase 3.19
SOS2-like protein kinase PKS14
Gene namesi
Name:CIPK22
Synonyms:PKS14, SnRK3.19
Ordered Locus Names:At2g38490
ORF Names:T19C21.2, T6A23.31
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G38490

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003372231 – 431CBL-interacting serine/threonine-protein kinase 22Add BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172PhosphoserineBy similarity1
Modified residuei186PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO80902

Expressioni

Gene expression databases

ExpressionAtlasiO80902 baseline and differential
GenevisibleiO80902 AT

Interactioni

Protein-protein interaction databases

BioGridi3773, 10 interactors
IntActiO80902, 9 interactors
STRINGi3702.AT2G38490.1

Structurei

3D structure databases

ProteinModelPortaliO80902
SMRiO80902
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 282Protein kinasePROSITE-ProRule annotationAdd BLAST255
Domaini303 – 327NAFPROSITE-ProRule annotationAdd BLAST25

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 197Activation loopBy similarityAdd BLAST30
Regioni333 – 363PPIBy similarityAdd BLAST31

Domaini

The activation loop within the kinase domain is the target of phosphorylation/activation by upstream protein kinases. The PPI motif mediates the interaction with the ABI (abscisic acid-insensitive) phosphatases (By similarity).By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
HOGENOMiHOG000233016
InParanoidiO80902
OrthoDBiEOG09360CC4
PhylomeDBiO80902

Family and domain databases

InterProiView protein in InterPro
IPR020636 Ca/CaM-dep_Ca-dep_prot_Kinase
IPR011009 Kinase-like_dom_sf
IPR018451 NAF/FISL_domain
IPR004041 NAF_dom
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR43895 PTHR43895, 1 hit
PfamiView protein in Pfam
PF03822 NAF, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50816 NAF, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

O80902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDSNSSES IIVNVTGDDN KSALFGKYDL GKLLGSGAFA KVYQAEDLQN
60 70 80 90 100
GGESVAIKVV QKKRLKDGLT AHVKREISVM RRLRHPHIVL LSEVLATKTK
110 120 130 140 150
IYFVMELAKG GELFSRVTSN RFTESLSRKY FRQLISAVRY CHARGVFHRD
160 170 180 190 200
LKPENLLLDE NRDLKVSDFG LSAMKEQIHP DGMLHTLCGT PAYVAPELLL
210 220 230 240 250
KKGYDGSKAD IWSCGVVLFL LNAGYLPFRD PNIMGLYRKI HKAQYKLPDW
260 270 280 290 300
TSSDLRKLLR RLLEPNPELR ITVEEILKDP WFNHGVDPSE IIGIQADDYD
310 320 330 340 350
LEENGKILNA FDLISSASSS NLSGLFGNFV TPDHCDQFVS DESTAVIMRK
360 370 380 390 400
VEEVAKQLNL RIAKKKERAI KLEGPHGVAN VVVKVRRLTN ELVMVEMKNK
410 420 430
QRDVGLVWAD ALRQKLRRLI NQPVYKVPDK P
Length:431
Mass (Da):48,680
Last modified:November 1, 1998 - v1
Checksum:i24B5E2F89E88FE72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450478 mRNA Translation: AAL47845.1
AC004683 Genomic DNA Translation: AAM14992.1
AC005499 Genomic DNA Translation: AAC67369.1
CP002685 Genomic DNA Translation: AEC09543.2
AY091782 mRNA Translation: AAM10329.1
BT000597 mRNA Translation: AAN18166.1
PIRiT02496
RefSeqiNP_181383.3, NM_129406.4
UniGeneiAt.28459

Genome annotation databases

EnsemblPlantsiAT2G38490.1; AT2G38490.1; AT2G38490
GeneIDi818431
GrameneiAT2G38490.1; AT2G38490.1; AT2G38490
KEGGiath:AT2G38490

Similar proteinsi

Entry informationi

Entry nameiCIPKM_ARATH
AccessioniPrimary (citable) accession number: O80902
Secondary accession number(s): F4ISZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health