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Protein

Internal alternative NAD(P)H-ubiquinone oxidoreductase A2, mitochondrial

Gene

NDA2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Alternative NADH-ubiquinone oxidoreductase which catalyzes the oxidation of mitochondrial NADH does not translocate protons across the inner mitochondrial membrane.By similarity

Catalytic activityi

NADH + ubiquinone = NAD+ + ubiquinol.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 103FADBy similarityAdd BLAST31
Nucleotide bindingi240 – 276NADBy similarityAdd BLAST37

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD, NADP, Ubiquinone

Enzyme and pathway databases

BioCyciARA:AT2G29990-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Internal alternative NAD(P)H-ubiquinone oxidoreductase A2, mitochondrial (EC:1.6.5.9)
Alternative name(s):
Internal alternative NADH dehydrogenase NDA2
NADH:ubiquinone reductase (non-electrogenic) NDA2
Gene namesi
Name:NDA2
Ordered Locus Names:At2g29990
ORF Names:F23F1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G29990.
TAIRilocus:2045708. AT2G29990.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionBy similarityAdd BLAST46
ChainiPRO_000041950447 – 508Internal alternative NAD(P)H-ubiquinone oxidoreductase A2, mitochondrialAdd BLAST462

Proteomic databases

PaxDbiO80874.

PTM databases

iPTMnetiO80874.
SwissPalmiO80874.

Expressioni

Tissue specificityi

Expressed in seedlings, roots, cotyledons, leaves, stems, buds and flowers.2 Publications

Inductioni

Accumulates in response to ammonium but repressed by nitrate.1 Publication

Gene expression databases

GenevisibleiO80874. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G29990.1.

Structurei

3D structure databases

ProteinModelPortaliO80874.
SMRiO80874.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi499 – 508Microbody targeting signal10

Sequence similaritiesi

Belongs to the NADH dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2495. Eukaryota.
COG1252. LUCA.
HOGENOMiHOG000182501.
InParanoidiO80874.
KOiK17871.
OMAiEVHCETL.
OrthoDBiEOG093607P8.
PhylomeDBiO80874.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR023753. FAD/NAD-binding_dom.
PfamiView protein in Pfam
PF07992. Pyr_redox_2. 1 hit.
SUPFAMiSSF51905. SSF51905. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O80874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFMIKNLTRI SPNTSSIITR FRNSGSSSLS YTLASRFCTA QETQIQSPAK
60 70 80 90 100
IPNDVDRSQY SGLPPTREGE KPRVVVLGSG WAGCRLMKGI DTNLYDVVCV
110 120 130 140 150
SPRNHMVFTP LLASTCVGTL EFRSVAEPIS RIQPAISREP GSFFFLANCS
160 170 180 190 200
RLDADAHEVH CETLTDGLNT LKPWKFKIAY DKLVIASGAE ASTFGIHGVM
210 220 230 240 250
ENAIFLREVH HAQEIRRKLL LNLMLSDTPG ISKEEKRRLL HCVVVGGGPT
260 270 280 290 300
GVEFSGELSD FIMKDVRQRY AHVKDDIHVT LIEARDILSS FDDRLRRYAI
310 320 330 340 350
KQLNKSGVRF VRGIVKDVQS QKLILDDGTE VPYGLLVWST GVGPSPFVRS
360 370 380 390 400
LGLPKDPTGR IGIDEWMRVP SVQDVFAIGD CSGYLETTGK PTLPALAQVA
410 420 430 440 450
EREGKYLANL LNAIGKGNGG RANSAKEIEL GVPFVYKHLG SMATIGRYKA
460 470 480 490 500
LVDLRESKDA KGISMTGFVS WFIWRSAYLT RVISWRNRFY VAINWFTTFV

FGRDISRI
Length:508
Mass (Da):56,503
Last modified:November 1, 1998 - v1
Checksum:i266A434E702A0C27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004680 Genomic DNA. Translation: AAC31853.1.
CP002685 Genomic DNA. Translation: AEC08332.1.
PIRiT02486.
RefSeqiNP_180560.1. NM_128553.3.
UniGeneiAt.38412.

Genome annotation databases

EnsemblPlantsiAT2G29990.1; AT2G29990.1; AT2G29990.
GeneIDi817549.
GrameneiAT2G29990.1; AT2G29990.1; AT2G29990.
KEGGiath:AT2G29990.

Similar proteinsi

Entry informationi

Entry nameiNDA2_ARATH
AccessioniPrimary (citable) accession number: O80874
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: November 1, 1998
Last modified: October 25, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families