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Protein

Actin-related protein 2/3 complex subunit 1A

Gene

ARPC1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.By similarity

GO - Molecular functioni

GO - Biological processi

  • actin filament organization Source: TAIR
  • Arp2/3 complex-mediated actin nucleation Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1A
Alternative name(s):
Actin-related protein C1
Actin-related protein C1A
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene namesi
Name:ARPC1A
Ordered Locus Names:At2g30910
ORF Names:F7F1.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G30910.

Subcellular locationi

GO - Cellular componenti

  • Arp2/3 protein complex Source: TAIR
  • cytoplasm Source: TAIR
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Actin-related protein 2/3 complex subunit 1APRO_0000422526Add
BLAST

Proteomic databases

PaxDbiO80856.
PRIDEiO80856.

Expressioni

Tissue specificityi

Expressed at low levels in all tissues with a relatively highest expression in inflorescences.1 Publication

Gene expression databases

ExpressionAtlasiO80856. baseline.
GenevisibleiO80856. AT.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2990. 1 interaction.
STRINGi3702.AT2G30910.1.

Structurei

3D structure databases

ProteinModelPortaliO80856.
SMRiO80856. Positions 7-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 4740WD 1Add
BLAST
Repeati53 – 9240WD 2Add
BLAST
Repeati97 – 13842WD 3Add
BLAST
Repeati143 – 18240WD 4Add
BLAST
Repeati203 – 24240WD 5Add
BLAST
Repeati257 – 29539WD 6Add
BLAST
Repeati331 – 37545WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1523. Eukaryota.
ENOG410XNWX. LUCA.
HOGENOMiHOG000181752.
InParanoidiO80856.
KOiK05757.
OMAiINEIRVY.
PhylomeDBiO80856.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PfamiPF12894. ANAPC4_WD40. 1 hit.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: O80856-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVVDVHRFA ESITCHAWSP DLSMVALCPN NTEVHIYKSL SQDHWERLHV
60 70 80 90 100
LQKHDQIVSG IDWSSKSNKI VTVSHDRNSY VWSLEGAEWV PTLVILRLNR
110 120 130 140 150
AALCVQWSPK ENKFAVGSGA KTVCICYYEQ ENNWWVSKLI RKRHESSVTS
160 170 180 190 200
VAWHPNNVLL ATTSTDGKCR VFSTFIKGVD TKDSKAGSPA ETKFGEQILQ
210 220 230 240 250
LDLSYSWAFG VKWSPSGNTL AYVGHSSMIY FVDDVGPSPL AQSVAFRDLP
260 270 280 290 300
LRDVLFISEK MVIGVGYDSN PMVFASDDTG IWSFIRYIGE KKAASSNSSY
310 320 330 340 350
SSQFSEAFGK FYGSQSKSTT ANDASESRGG VHDNCINSIV SLSKAGSPKV
360 370
MRFSTSGLDG KVAIWDLENM EQELGNQF
Length:378
Mass (Da):41,956
Last modified:November 1, 1998 - v1
Checksum:iC8A38111E5472188
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004669 Genomic DNA. Translation: AAC20725.1.
CP002685 Genomic DNA. Translation: AEC08455.1.
CP002685 Genomic DNA. Translation: AEC08457.1.
BT004616 mRNA. Translation: AAO42862.1.
AK227543 mRNA. Translation: BAE99541.1.
PIRiB84714.
RefSeqiNP_001189645.1. NM_001202716.1. [O80856-1]
NP_180648.1. NM_128643.3. [O80856-1]
UniGeneiAt.48535.
At.71148.

Genome annotation databases

EnsemblPlantsiAT2G30910.1; AT2G30910.1; AT2G30910. [O80856-1]
AT2G30910.3; AT2G30910.3; AT2G30910. [O80856-1]
GeneIDi817641.
KEGGiath:AT2G30910.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004669 Genomic DNA. Translation: AAC20725.1.
CP002685 Genomic DNA. Translation: AEC08455.1.
CP002685 Genomic DNA. Translation: AEC08457.1.
BT004616 mRNA. Translation: AAO42862.1.
AK227543 mRNA. Translation: BAE99541.1.
PIRiB84714.
RefSeqiNP_001189645.1. NM_001202716.1. [O80856-1]
NP_180648.1. NM_128643.3. [O80856-1]
UniGeneiAt.48535.
At.71148.

3D structure databases

ProteinModelPortaliO80856.
SMRiO80856. Positions 7-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2990. 1 interaction.
STRINGi3702.AT2G30910.1.

Proteomic databases

PaxDbiO80856.
PRIDEiO80856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G30910.1; AT2G30910.1; AT2G30910. [O80856-1]
AT2G30910.3; AT2G30910.3; AT2G30910. [O80856-1]
GeneIDi817641.
KEGGiath:AT2G30910.

Organism-specific databases

TAIRiAT2G30910.

Phylogenomic databases

eggNOGiKOG1523. Eukaryota.
ENOG410XNWX. LUCA.
HOGENOMiHOG000181752.
InParanoidiO80856.
KOiK05757.
OMAiINEIRVY.
PhylomeDBiO80856.

Miscellaneous databases

PROiO80856.

Gene expression databases

ExpressionAtlasiO80856. baseline.
GenevisibleiO80856. AT.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PfamiPF12894. ANAPC4_WD40. 1 hit.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "The putative Arabidopsis arp2/3 complex controls leaf cell morphogenesis."
    Li S., Blanchoin L., Yang Z., Lord E.M.
    Plant Physiol. 132:2034-2044(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, IDENTIFICATION OF THE ARP2/3 COMPLEX.
  6. "Breaking the WAVE complex: the point of Arabidopsis trichomes."
    Szymanski D.B.
    Curr. Opin. Plant Biol. 8:103-112(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiARC1A_ARATH
AccessioniPrimary (citable) accession number: O80856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.