Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat receptor-like protein CLAVATA2

Gene

CLV2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the perception of CLV3 and CLV3-like peptides, that act as extracellular signals regulating meristems maintenance. Involved in controlling the stem cell population size in shoot and root apical meristems, and during organ development. Promotes the formation of CLV1 multimers.5 Publications

GO - Molecular functioni

  • receptor serine/threonine kinase binding Source: UniProtKB

GO - Biological processi

  • meristem development Source: TAIR
  • multicellular organism development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat receptor-like protein CLAVATA2
Alternative name(s):
Receptor-like protein 10
Short name:
AtRLP10
Gene namesi
Name:CLV2
Synonyms:RLP10
Ordered Locus Names:At1g65380
ORF Names:T8F5.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G65380.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 686ExtracellularSequence analysisAdd BLAST661
Transmembranei687 – 707HelicalSequence analysisAdd BLAST21
Topological domaini708 – 720CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: TAIR
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Enlarged shoot and flower meristems, as well as alterations in the development of the gynoecia, flower pedicels, and stamens. Reduced sensitivity to CLV3, CLE19 and CLE40 peptides.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000040121226 – 720Leucine-rich repeat receptor-like protein CLAVATA2Add BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...)Sequence analysis1
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Glycosylationi270N-linked (GlcNAc...)Sequence analysis1
Glycosylationi361N-linked (GlcNAc...)Sequence analysis1
Glycosylationi398N-linked (GlcNAc...)Sequence analysis1
Glycosylationi446N-linked (GlcNAc...)Sequence analysis1
Glycosylationi505N-linked (GlcNAc...)Sequence analysis1
Glycosylationi578N-linked (GlcNAc...)Sequence analysis1
Glycosylationi614N-linked (GlcNAc...)Sequence analysis1
Glycosylationi625N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO80809.

Expressioni

Tissue specificityi

Mostly expressed in apices (e.g. shoot apical meristem and flower buds), and, to a lower extent, in flowers, leaves, seedlings and siliques.1 Publication

Gene expression databases

GenevisibleiO80809. AT.

Interactioni

Subunit structurei

Parts of a tetrameric complex made of one CRN dimer and two CLV2 that can interact with CLV3 and CLV1 dimers. Interacts with CRN.3 Publications

GO - Molecular functioni

  • receptor serine/threonine kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi28070. 8 interactors.
STRINGi3702.AT1G65380.1.

Structurei

3D structure databases

ProteinModelPortaliO80809.
SMRiO80809.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati74 – 97LRR 1Add BLAST24
Repeati98 – 120LRR 2Add BLAST23
Repeati122 – 145LRR 3Add BLAST24
Repeati146 – 165LRR 4Add BLAST20
Repeati241 – 260LRR 5Add BLAST20
Repeati265 – 287LRR 6Add BLAST23
Repeati289 – 311LRR 7Add BLAST23
Repeati316 – 339LRR 8Add BLAST24
Repeati340 – 363LRR 9Add BLAST24
Repeati364 – 385LRR 10Add BLAST22
Repeati388 – 411LRR 11Add BLAST24
Repeati412 – 435LRR 12Add BLAST24
Repeati436 – 457LRR 13Add BLAST22
Repeati460 – 482LRR 14Add BLAST23
Repeati484 – 505LRR 15Add BLAST22
Repeati549 – 571LRR 16Add BLAST23
Repeati573 – 595LRR 17Add BLAST23
Repeati596 – 619LRR 18Add BLAST24
Repeati620 – 641LRR 19Add BLAST22

Sequence similaritiesi

Contains 19 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
InParanoidiO80809.
OMAiGPISIWI.
OrthoDBiEOG093603WH.
PhylomeDBiO80809.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 10 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
PROSITEiPS51450. LRR. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O80809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKIADFTLF FFIFVFSPSL PLAQSQLPDL DPQDKASLLI FRVSIHDLNR
60 70 80 90 100
SLSTWYGSSC SNWTGLACQN PTGKVLSLTL SGLNLSSQIH PSLCKLSSLQ
110 120 130 140 150
SLDLSHNNFS GNIPSCFGSL RNLRTLNLSR NRFVGSIPAT FVSLKELREV
160 170 180 190 200
VLSENRDLGG VVPHWFGNFS MNLERVDFSF CSFVGELPES LLYLKSLKYL
210 220 230 240 250
NLESNNMTGT LRDFQQPLVV LNLASNQFSG TLPCFYASRP SLSILNIAEN
260 270 280 290 300
SLVGGLPSCL GSLKELSHLN LSFNGFNYEI SPRLMFSEKL VMLDLSHNGF
310 320 330 340 350
SGRLPSRISE TTEKLGLVLL DLSHNSFSGD IPLRITELKS LQALRLSHNL
360 370 380 390 400
LTGDIPARIG NLTYLQVIDL SHNALTGSIP LNIVGCFQLL ALMISNNNLS
410 420 430 440 450
GEIQPELDAL DSLKILDISN NHISGEIPLT LAGLKSLEIV DISSNNLSGN
460 470 480 490 500
LNEAITKWSN LKYLSLARNK FSGTLPSWLF KFDKIQMIDY SSNRFSWFIP
510 520 530 540 550
DDNLNSTRFK DFQTGGGEGF AEPPGKVEIK ISAAVVAKDE LSFSYNLLSM
560 570 580 590 600
VGIDLSDNLL HGEIPEALFR QKNIEYLNLS YNFLEGQLPR LEKLPRLKAL
610 620 630 640 650
DLSHNSLSGQ VIGNISAPPG LTLLNLSHNC FSGIITEKEG LGKFPGALAG
660 670 680 690 700
NPELCVETPG SKCDPANIDA SQEEIYQNEL VEGPISIWIF CLSAFISFDF
710 720
GVLGIFCSAR ARSYILQTKA
Length:720
Mass (Da):79,228
Last modified:November 1, 1998 - v1
Checksum:iB5FA831683451831
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti80L → S in strain: cv. Chi-1, cv. Wassilewskija. 2 Publications1
Natural varianti87S → G in strain: cv. An-2, cv. Bla-1, cv. Bs-1, cv. Bu-0, cv. Chi-1, cv. Co-1, cv. Cvi-0, cv. El-0, cv. Gr-3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lisse-2, cv. Lu-1, cv. Pi-0, cv. Sf-1, cv. Wassilewskija. 2 Publications1
Natural varianti110S → C in strain: cv. Landsberg erecta. 2 Publications1
Natural varianti125T → I in strain: cv. An-2, cv. Bla-1, cv. Bs-1, cv. Chi-1, cv. Cvi-0, cv. Lisse-2, cv. Sf-1, cv. Wassilewskija. 2 Publications1
Natural varianti134V → I in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications1
Natural varianti139 – 142ATFV → PTFM in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications4
Natural varianti139A → T in strain: cv. An-2. 1 Publication1
Natural varianti148R → G in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications1
Natural varianti157D → N in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications1
Natural varianti162V → I in strain: cv. An-2, cv. Bla-1, cv. Bs-1, cv. Chi-1, cv. Cvi-0, cv. Lisse-2, cv. Sf-1, cv. Wassilewskija. 2 Publications1
Natural varianti168N → D in strain: cv. An-2, cv. Bla-1, cv. Bs-1, cv. Bu-0, cv. Chi-1, cv. Co-1, cv. Cvi-0, cv. El-0, cv. Gr-3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lisse-2, cv. Lu-1, cv. Pi-0, cv. Sf-1, cv. Wassilewskija. 2 Publications1
Natural varianti178F → I in strain: cv. An-2, cv. Bla-1, cv. Bs-1, cv. Chi-1, cv. Cvi-0, cv. Lisse-2, cv. Sf-1, cv. Wassilewskija. 2 Publications1
Natural varianti178F → L in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications1
Natural varianti207M → I in strain: cv. Ita-0. 1 Publication1
Natural varianti227Q → R in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications1
Natural varianti244 – 247ILNI → VLNL in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications4
Natural varianti264K → T in strain: cv. Ita-0. 1 Publication1
Natural varianti285M → V in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications1
Natural varianti303R → C in strain: cv. Ita-0. 1 Publication1
Natural varianti374A → S in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications1
Natural varianti572K → R in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti649A → T in strain: cv. Wassilewskija. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177672 Genomic DNA. Translation: AAF02654.1.
AF177673 Genomic DNA. Translation: AAF02655.1.
AF177674 Genomic DNA. Translation: AAF02656.1.
AC004512 Genomic DNA. Translation: AAC27153.1.
CP002684 Genomic DNA. Translation: AEE34367.1.
AY065442 mRNA. Translation: AAL38883.1.
AY096537 mRNA. Translation: AAM20187.1.
AF528591 Genomic DNA. Translation: AAO43328.1.
AF528592 Genomic DNA. Translation: AAO43329.1.
AF528593 Genomic DNA. Translation: AAO43330.1.
AF528594 Genomic DNA. Translation: AAO43331.1.
AF528595 Genomic DNA. Translation: AAO43332.1.
AF528596 Genomic DNA. Translation: AAO43333.1.
AF528597 Genomic DNA. Translation: AAO43334.1.
AF528598 Genomic DNA. Translation: AAO43335.1.
AF528599 Genomic DNA. Translation: AAO43336.1.
AF528600 Genomic DNA. Translation: AAO43337.1.
AF528601 Genomic DNA. Translation: AAO43338.1.
AF528602 Genomic DNA. Translation: AAO43339.1.
AF528603 Genomic DNA. Translation: AAO43340.1.
AF528604 Genomic DNA. Translation: AAO43341.1.
AF528605 Genomic DNA. Translation: AAO43342.1.
AF528606 Genomic DNA. Translation: AAO43343.1.
AF528607 Genomic DNA. Translation: AAO43344.1.
AF528608 Genomic DNA. Translation: AAO43345.1.
AF528609 Genomic DNA. Translation: AAO43346.1.
AF528610 Genomic DNA. Translation: AAO43347.1.
AF528611 Genomic DNA. Translation: AAO43348.1.
PIRiT02361.
RefSeqiNP_176717.1. NM_105212.3.
UniGeneiAt.17109.

Genome annotation databases

EnsemblPlantsiAT1G65380.1; AT1G65380.1; AT1G65380.
GeneIDi842849.
GrameneiAT1G65380.1; AT1G65380.1; AT1G65380.
KEGGiath:AT1G65380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177672 Genomic DNA. Translation: AAF02654.1.
AF177673 Genomic DNA. Translation: AAF02655.1.
AF177674 Genomic DNA. Translation: AAF02656.1.
AC004512 Genomic DNA. Translation: AAC27153.1.
CP002684 Genomic DNA. Translation: AEE34367.1.
AY065442 mRNA. Translation: AAL38883.1.
AY096537 mRNA. Translation: AAM20187.1.
AF528591 Genomic DNA. Translation: AAO43328.1.
AF528592 Genomic DNA. Translation: AAO43329.1.
AF528593 Genomic DNA. Translation: AAO43330.1.
AF528594 Genomic DNA. Translation: AAO43331.1.
AF528595 Genomic DNA. Translation: AAO43332.1.
AF528596 Genomic DNA. Translation: AAO43333.1.
AF528597 Genomic DNA. Translation: AAO43334.1.
AF528598 Genomic DNA. Translation: AAO43335.1.
AF528599 Genomic DNA. Translation: AAO43336.1.
AF528600 Genomic DNA. Translation: AAO43337.1.
AF528601 Genomic DNA. Translation: AAO43338.1.
AF528602 Genomic DNA. Translation: AAO43339.1.
AF528603 Genomic DNA. Translation: AAO43340.1.
AF528604 Genomic DNA. Translation: AAO43341.1.
AF528605 Genomic DNA. Translation: AAO43342.1.
AF528606 Genomic DNA. Translation: AAO43343.1.
AF528607 Genomic DNA. Translation: AAO43344.1.
AF528608 Genomic DNA. Translation: AAO43345.1.
AF528609 Genomic DNA. Translation: AAO43346.1.
AF528610 Genomic DNA. Translation: AAO43347.1.
AF528611 Genomic DNA. Translation: AAO43348.1.
PIRiT02361.
RefSeqiNP_176717.1. NM_105212.3.
UniGeneiAt.17109.

3D structure databases

ProteinModelPortaliO80809.
SMRiO80809.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi28070. 8 interactors.
STRINGi3702.AT1G65380.1.

Proteomic databases

PaxDbiO80809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G65380.1; AT1G65380.1; AT1G65380.
GeneIDi842849.
GrameneiAT1G65380.1; AT1G65380.1; AT1G65380.
KEGGiath:AT1G65380.

Organism-specific databases

TAIRiAT1G65380.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
InParanoidiO80809.
OMAiGPISIWI.
OrthoDBiEOG093603WH.
PhylomeDBiO80809.

Miscellaneous databases

PROiO80809.

Gene expression databases

GenevisibleiO80809. AT.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 10 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
PROSITEiPS51450. LRR. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLV2_ARATH
AccessioniPrimary (citable) accession number: O80809
Secondary accession number(s): Q84JK9
, Q84JT8, Q84JU7, Q84K94, Q84VM8, Q84VM9, Q84VN0, Q9SPE8, Q9SPE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.