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Protein

Receptor-like protein CLAVATA2

Gene

CLV2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the perception of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristems maintenance. Involved in controlling the stem cell population size in shoot and root apical meristems, and during organ development. Promotes the formation of CLV1 multimers. In complex with CRN, perceives secreted CLV3-like effector proteins from plant-parasitic cyst nematodes as ligand mimics of the plant CLE signaling pathway (PubMed:21265896, PubMed:21750229). This recognition is required for proper feeding structure (syncytium) development and ultimately successful nematode infection (PubMed:21265896, PubMed:21750229). CLE14 perception by CLV2/CRN complex triggers root meristem differentiation (PubMed:20697738, PubMed:28586647).9 Publications

GO - Biological processi

  • meristem development Source: TAIR
  • multicellular organism development Source: UniProtKB-KW
  • regulation of meristem growth Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-like protein CLAVATA2Imported
Alternative name(s):
Receptor-like protein 101 Publication
Short name:
AtRLP101 Publication
Gene namesi
Name:CLV2Imported
Synonyms:RLP101 Publication
Ordered Locus Names:At1g65380Imported
ORF Names:T8F5.16Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G65380
TAIRilocus:2206245 AT1G65380

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 686ExtracellularSequence analysisAdd BLAST661
Transmembranei687 – 707HelicalSequence analysisAdd BLAST21
Topological domaini708 – 720CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Stem cell proliferation leading to enlarged shoot and flower meristems, as well as alterations in the development of the gynoecia, flower pedicels, and stamens. Reduced sensitivity to CLV3, CLE19 and CLE40 peptides. Ectopic fruit organ initiation after floral meristem termination (PubMed:21705761). Enhanced resistance to nematode infection (PubMed:21265896). Enhanced disease resistance response to the bacterial pathogen Ralstonia solanacearum and to the biotrophic oomycete pathogen Hyaloperonospora arabidopsidis (PubMed:26990325).5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000040121226 – 720Receptor-like protein CLAVATA2Add BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi270N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi578N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi614N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi625N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO80809
PRIDEiO80809

Expressioni

Tissue specificityi

Mostly expressed in apices (e.g. shoot apical meristem and flower buds), and, to a lower extent, in flowers, leaves, seedlings and siliques. Also expressed in the inner tissues of the proximal root meristem (PubMed:21265896).2 Publications

Gene expression databases

ExpressionAtlasiO80809 baseline and differential
GenevisibleiO80809 AT

Interactioni

Subunit structurei

Parts of a tetrameric complex made of two CLV2/CRN heterodimers that can interact with CLV3 and CLE peptides. CLV2/CRN heterodimer interacts with CLV1 homodimers. Interacts with CRN. Interacts with CLE14 (PubMed:28586647).6 Publications

Protein-protein interaction databases

BioGridi28070, 8 interactors
IntActiO80809, 3 interactors
STRINGi3702.AT1G65380.1

Structurei

3D structure databases

ProteinModelPortaliO80809
SMRiO80809
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati96 – 122LRR 1Sequence analysisAdd BLAST27
Repeati124 – 144LRR 2Sequence analysisAdd BLAST21
Repeati146 – 168LRR 3Sequence analysisAdd BLAST23
Repeati170 – 194LRR 4Sequence analysisAdd BLAST25
Repeati195 – 217LRR 5Sequence analysisAdd BLAST23
Repeati219 – 238LRR 6Sequence analysisAdd BLAST20
Repeati239 – 263LRR 7Sequence analysisAdd BLAST25
Repeati264 – 287LRR 8Sequence analysisAdd BLAST24
Repeati288 – 311LRR 9Sequence analysisAdd BLAST24
Repeati314 – 338LRR 10Sequence analysisAdd BLAST25
Repeati339 – 362LRR 11Sequence analysisAdd BLAST24
Repeati364 – 386LRR 12Sequence analysisAdd BLAST23
Repeati388 – 410LRR 13Sequence analysisAdd BLAST23
Repeati411 – 436LRR 14Sequence analysisAdd BLAST26
Repeati438 – 458LRR 15Sequence analysisAdd BLAST21
Repeati459 – 482LRR 16Sequence analysisAdd BLAST24
Repeati484 – 506LRR 17Sequence analysisAdd BLAST23
Repeati547 – 571LRR 18Sequence analysisAdd BLAST25
Repeati573 – 594LRR 19Sequence analysisAdd BLAST22
Repeati595 – 617LRR 20Sequence analysisAdd BLAST23
Repeati619 – 641LRR 21Sequence analysisAdd BLAST23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 92N-cap1 PublicationAdd BLAST67
Regioni649 – 682C-cap/acidic domain1 PublicationAdd BLAST34

Sequence similaritiesi

Belongs to the RLP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
InParanoidiO80809
OMAiIHDLNRS
OrthoDBiEOG093603WH
PhylomeDBiO80809

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 10 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 14 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O80809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKIADFTLF FFIFVFSPSL PLAQSQLPDL DPQDKASLLI FRVSIHDLNR
60 70 80 90 100
SLSTWYGSSC SNWTGLACQN PTGKVLSLTL SGLNLSSQIH PSLCKLSSLQ
110 120 130 140 150
SLDLSHNNFS GNIPSCFGSL RNLRTLNLSR NRFVGSIPAT FVSLKELREV
160 170 180 190 200
VLSENRDLGG VVPHWFGNFS MNLERVDFSF CSFVGELPES LLYLKSLKYL
210 220 230 240 250
NLESNNMTGT LRDFQQPLVV LNLASNQFSG TLPCFYASRP SLSILNIAEN
260 270 280 290 300
SLVGGLPSCL GSLKELSHLN LSFNGFNYEI SPRLMFSEKL VMLDLSHNGF
310 320 330 340 350
SGRLPSRISE TTEKLGLVLL DLSHNSFSGD IPLRITELKS LQALRLSHNL
360 370 380 390 400
LTGDIPARIG NLTYLQVIDL SHNALTGSIP LNIVGCFQLL ALMISNNNLS
410 420 430 440 450
GEIQPELDAL DSLKILDISN NHISGEIPLT LAGLKSLEIV DISSNNLSGN
460 470 480 490 500
LNEAITKWSN LKYLSLARNK FSGTLPSWLF KFDKIQMIDY SSNRFSWFIP
510 520 530 540 550
DDNLNSTRFK DFQTGGGEGF AEPPGKVEIK ISAAVVAKDE LSFSYNLLSM
560 570 580 590 600
VGIDLSDNLL HGEIPEALFR QKNIEYLNLS YNFLEGQLPR LEKLPRLKAL
610 620 630 640 650
DLSHNSLSGQ VIGNISAPPG LTLLNLSHNC FSGIITEKEG LGKFPGALAG
660 670 680 690 700
NPELCVETPG SKCDPANIDA SQEEIYQNEL VEGPISIWIF CLSAFISFDF
710 720
GVLGIFCSAR ARSYILQTKA
Length:720
Mass (Da):79,228
Last modified:November 1, 1998 - v1
Checksum:iB5FA831683451831
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti80L → S in strain: cv. Chi-1, cv. Wassilewskija. 2 Publications1
Natural varianti87S → G in strain: cv. An-2, cv. Bla-1, cv. Bs-1, cv. Bu-0, cv. Chi-1, cv. Co-1, cv. Cvi-0, cv. El-0, cv. Gr-3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lisse-2, cv. Lu-1, cv. Pi-0, cv. Sf-1, cv. Wassilewskija. 2 Publications1
Natural varianti110S → C in strain: cv. Landsberg erecta. 2 Publications1
Natural varianti125T → I in strain: cv. An-2, cv. Bla-1, cv. Bs-1, cv. Chi-1, cv. Cvi-0, cv. Lisse-2, cv. Sf-1, cv. Wassilewskija. 2 Publications1
Natural varianti134V → I in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications1
Natural varianti139 – 142ATFV → PTFM in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications4
Natural varianti139A → T in strain: cv. An-2. 1 Publication1
Natural varianti148R → G in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications1
Natural varianti157D → N in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications1
Natural varianti162V → I in strain: cv. An-2, cv. Bla-1, cv. Bs-1, cv. Chi-1, cv. Cvi-0, cv. Lisse-2, cv. Sf-1, cv. Wassilewskija. 2 Publications1
Natural varianti168N → D in strain: cv. An-2, cv. Bla-1, cv. Bs-1, cv. Bu-0, cv. Chi-1, cv. Co-1, cv. Cvi-0, cv. El-0, cv. Gr-3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lisse-2, cv. Lu-1, cv. Pi-0, cv. Sf-1, cv. Wassilewskija. 2 Publications1
Natural varianti178F → I in strain: cv. An-2, cv. Bla-1, cv. Bs-1, cv. Chi-1, cv. Cvi-0, cv. Lisse-2, cv. Sf-1, cv. Wassilewskija. 2 Publications1
Natural varianti178F → L in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications1
Natural varianti207M → I in strain: cv. Ita-0. 1 Publication1
Natural varianti227Q → R in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications1
Natural varianti244 – 247ILNI → VLNL in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications4
Natural varianti264K → T in strain: cv. Ita-0. 1 Publication1
Natural varianti285M → V in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications1
Natural varianti303R → C in strain: cv. Ita-0. 1 Publication1
Natural varianti374A → S in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv. Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1, cv. Pi-0. 2 Publications1
Natural varianti572K → R in strain: cv. Landsberg erecta. 1 Publication1
Natural varianti649A → T in strain: cv. Wassilewskija. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177672 Genomic DNA Translation: AAF02654.1
AF177673 Genomic DNA Translation: AAF02655.1
AF177674 Genomic DNA Translation: AAF02656.1
AC004512 Genomic DNA Translation: AAC27153.1
CP002684 Genomic DNA Translation: AEE34367.1
AY065442 mRNA Translation: AAL38883.1
AY096537 mRNA Translation: AAM20187.1
AF528591 Genomic DNA Translation: AAO43328.1
AF528592 Genomic DNA Translation: AAO43329.1
AF528593 Genomic DNA Translation: AAO43330.1
AF528594 Genomic DNA Translation: AAO43331.1
AF528595 Genomic DNA Translation: AAO43332.1
AF528596 Genomic DNA Translation: AAO43333.1
AF528597 Genomic DNA Translation: AAO43334.1
AF528598 Genomic DNA Translation: AAO43335.1
AF528599 Genomic DNA Translation: AAO43336.1
AF528600 Genomic DNA Translation: AAO43337.1
AF528601 Genomic DNA Translation: AAO43338.1
AF528602 Genomic DNA Translation: AAO43339.1
AF528603 Genomic DNA Translation: AAO43340.1
AF528604 Genomic DNA Translation: AAO43341.1
AF528605 Genomic DNA Translation: AAO43342.1
AF528606 Genomic DNA Translation: AAO43343.1
AF528607 Genomic DNA Translation: AAO43344.1
AF528608 Genomic DNA Translation: AAO43345.1
AF528609 Genomic DNA Translation: AAO43346.1
AF528610 Genomic DNA Translation: AAO43347.1
AF528611 Genomic DNA Translation: AAO43348.1
PIRiT02361
RefSeqiNP_176717.1, NM_105212.3
UniGeneiAt.17109

Genome annotation databases

EnsemblPlantsiAT1G65380.1; AT1G65380.1; AT1G65380
GeneIDi842849
GrameneiAT1G65380.1; AT1G65380.1; AT1G65380
KEGGiath:AT1G65380

Similar proteinsi

Entry informationi

Entry nameiCLV2_ARATH
AccessioniPrimary (citable) accession number: O80809
Secondary accession number(s): Q84JK9
, Q84JT8, Q84JU7, Q84K94, Q84VM8, Q84VM9, Q84VN0, Q9SPE8, Q9SPE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health