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Protein

MADS-box transcription factor PHERES 1

Gene

PHE1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor involved in the development of gametophytes and seeds.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • embryo development ending in seed dormancy Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MADS-box transcription factor PHERES 1
Alternative name(s):
Agamous-like MADS-box protein AGL37
Gene namesi
Name:PHE1
Synonyms:AGL37
Ordered Locus Names:At1g65330
ORF Names:T8F5.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G65330.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: TAIR
  • pollen tube Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279MADS-box transcription factor PHERES 1PRO_0000233175Add
BLAST

Proteomic databases

PaxDbiO80805.
PRIDEiO80805.

Expressioni

Tissue specificityi

Male gametophyte, embryo and endosperm.2 Publications

Developmental stagei

Not present in female gametophyte before fertilization. Expressed in pollen tube and at the micropylar pole of pollinated seeds.1 Publication

Inductioni

Repressed by MEA, FIS2 and FIE in seeds, and by PKL after germination.2 Publications

Gene expression databases

GenevisibleiO80805. AT.

Interactioni

Subunit structurei

Interacts with AGL61/DIANA and AGL62.2 Publications

Protein-protein interaction databases

BioGridi28062. 6 interactions.
IntActiO80805. 7 interactions.
STRINGi3702.AT1G65330.1.

Structurei

3D structure databases

ProteinModelPortaliO80805.
SMRiO80805. Positions 2-75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6060MADS-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MADS-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000006067.
InParanoidiO80805.
OMAiVIRRVEI.
OrthoDBiEOG09360OKC.
PhylomeDBiO80805.

Family and domain databases

InterProiIPR002100. TF_MADSbox.
[Graphical view]
PfamiPF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS50066. MADS_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O80805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGKMKLSFI ENDSVRKTTF TKRKKGMLKK FNELVTLCGV DACAVIRSPY
60 70 80 90 100
NSIQEPWPSR EGVEEVMSKF MEFSVLDRTK KMVDQETFLR QRIAKETERL
110 120 130 140 150
QKLRDENRNS QIRDLMFGCL KGEVDVSHLH GRDLLDLNVF LNKYLNGVIR
160 170 180 190 200
RVEILKENGE SSSSVPPPIG VAPTVVDASV PIGFDGRMIQ DQNQNQQEPV
210 220 230 240 250
QFQYQALYDF YDQIPKKLHD FNMKMNIDPN QSMNLDLNDG EDEGIPCMDN
260 270
NNYHPEIDCL ATVTTAPTDV CAPNIINDL
Length:279
Mass (Da):31,953
Last modified:November 1, 1998 - v1
Checksum:iC054157870B8AE15
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti76 – 761L → I in strain: cv. Bla-1, cv. Bs-1, cv. Ita-0 and cv. Kas-1. 1 Publication
Natural varianti128 – 1281H → Q in strain: cv. Lisse-2. 1 Publication
Natural varianti169 – 1691I → T in strain: cv. Gr-3. 1 Publication
Natural varianti230 – 2301N → D in strain: cv. Co-1. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004512 Genomic DNA. Translation: AAC27144.1.
CP002684 Genomic DNA. Translation: AEE34359.1.
AF528574 Genomic DNA. Translation: AAO43311.1.
AF528575 Genomic DNA. Translation: AAO43312.1.
AF528576 Genomic DNA. Translation: AAO43313.1.
AF528577 Genomic DNA. Translation: AAO43314.1.
AF528578 Genomic DNA. Translation: AAO43315.1.
AF528579 Genomic DNA. Translation: AAO43316.1.
AF528580 Genomic DNA. Translation: AAO43317.1.
AF528581 Genomic DNA. Translation: AAO43318.1.
AF528582 Genomic DNA. Translation: AAO43319.1.
PIRiT02356.
RefSeqiNP_176712.1. NM_105207.1.
UniGeneiAt.64882.

Genome annotation databases

EnsemblPlantsiAT1G65330.1; AT1G65330.1; AT1G65330.
GeneIDi842841.
GrameneiAT1G65330.1; AT1G65330.1; AT1G65330.
KEGGiath:AT1G65330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004512 Genomic DNA. Translation: AAC27144.1.
CP002684 Genomic DNA. Translation: AEE34359.1.
AF528574 Genomic DNA. Translation: AAO43311.1.
AF528575 Genomic DNA. Translation: AAO43312.1.
AF528576 Genomic DNA. Translation: AAO43313.1.
AF528577 Genomic DNA. Translation: AAO43314.1.
AF528578 Genomic DNA. Translation: AAO43315.1.
AF528579 Genomic DNA. Translation: AAO43316.1.
AF528580 Genomic DNA. Translation: AAO43317.1.
AF528581 Genomic DNA. Translation: AAO43318.1.
AF528582 Genomic DNA. Translation: AAO43319.1.
PIRiT02356.
RefSeqiNP_176712.1. NM_105207.1.
UniGeneiAt.64882.

3D structure databases

ProteinModelPortaliO80805.
SMRiO80805. Positions 2-75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi28062. 6 interactions.
IntActiO80805. 7 interactions.
STRINGi3702.AT1G65330.1.

Proteomic databases

PaxDbiO80805.
PRIDEiO80805.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G65330.1; AT1G65330.1; AT1G65330.
GeneIDi842841.
GrameneiAT1G65330.1; AT1G65330.1; AT1G65330.
KEGGiath:AT1G65330.

Organism-specific databases

TAIRiAT1G65330.

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000006067.
InParanoidiO80805.
OMAiVIRRVEI.
OrthoDBiEOG09360OKC.
PhylomeDBiO80805.

Miscellaneous databases

PROiO80805.

Gene expression databases

GenevisibleiO80805. AT.

Family and domain databases

InterProiIPR002100. TF_MADSbox.
[Graphical view]
PfamiPF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS50066. MADS_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHE1_ARATH
AccessioniPrimary (citable) accession number: O80805
Secondary accession number(s): Q84JV4
, Q84JW5, Q84VN9, Q84VP0, Q84VP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The PHE1 locus is imprinted in gametophytes. Maternal inherited gene is repressed in female gametophyte, while the paternal inherited gene is expressed in the male gametophyte (pollen tube) and in fertilized seeds. The maternal repression is dependent on MEA, FIS2 and FIE proteins, which may modulate the methylation of the maternal locus, and repress its transcription.
This protein was called 'Pheres' in memory of one of the murdered sons of the mythological 'Medea', as PHERES1 is repressed by MEDEA.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.