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Protein

WD repeat-containing protein 55

Gene

WDR55

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for male and female gametogenesis, seed development, and embryo and endosperm development at early stages. Involved in the establishment of bilateral symmetry in the transition from the globular to the heart embryo stage. May act in the frame of a CRL4 complex (PubMed:22447688). Required for proper vegetative growth and organization of the adult plant body. May play a role in hormonal control of plant development (PubMed:23803743).2 Publications

GO - Biological processi

  • determination of bilateral symmetry Source: TAIR
  • developmental vegetative growth Source: UniProtKB
  • embryo development ending in seed dormancy Source: TAIR
  • embryo sac development Source: TAIR
  • endosperm development Source: TAIR
  • polar nucleus fusion Source: TAIR
  • ribosomal large subunit biogenesis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 55Curated
Alternative name(s):
Protein WD repeat domain 551 Publication
Protein WDR55 homologCurated
Gene namesi
Name:WDR551 Publication
Ordered Locus Names:At2g34260Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G34260.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: TAIR
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality when homozygous, due to embryo and endosperm developmental arrest at various stages ranging from the zygote stage to the globular stage. Failure in the fusion of the polar cells in embryo sac development.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004339931 – 353WD repeat-containing protein 55Add BLAST353

Proteomic databases

PaxDbiO80775.

PTM databases

iPTMnetiO80775.

Expressioni

Tissue specificityi

Highly expressed in roots. Expressed in cotyledons, leaves, buds and flowers.1 Publication

Developmental stagei

Expressed in female gametophyte throughout embryo sac development. During pollen development, expressed from meiosis up to the second pollen mitosis, but not at mature (three nucleate) stages.1 Publication

Gene expression databases

ExpressionAtlasiO80775. baseline and differential.
GenevisibleiO80775. AT.

Interactioni

Subunit structurei

Interacts with DDB1A.1 Publication

Protein-protein interaction databases

STRINGi3702.AT2G34260.1.

Structurei

3D structure databases

ProteinModelPortaliO80775.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 43WD 1Sequence analysisAdd BLAST40
Repeati49 – 88WD 2Sequence analysisAdd BLAST40
Repeati92 – 130WD 3Sequence analysisAdd BLAST39
Repeati133 – 172WD 4Sequence analysisAdd BLAST40
Repeati175 – 214WD 5Sequence analysisAdd BLAST40
Repeati218 – 257WD 6Sequence analysisAdd BLAST40
Repeati260 – 299WD 7Sequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the WD repeat WDR55 family.Curated
Contains 7 WD repeats.Sequence analysis

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2444. Eukaryota.
ENOG410ZHU5. LUCA.
HOGENOMiHOG000242496.
InParanoidiO80775.
OMAiYTHHFDF.
OrthoDBiEOG09360HMC.
PhylomeDBiO80775.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR017422. WDR55.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038169. WD_repeat_p55. 1 hit.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O80775-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIDLGANAF GIDFHPSTNL VAAGLIDGHL HLYRYDSDSS LVRERKVRAH
60 70 80 90 100
KESCRAVRFI DDGQRIVTAS ADCSILATDV ETGAQVAHLE NAHEDAVNTL
110 120 130 140 150
INVTETTIAS GDDKGCVKIW DTRQRSCSHE FNAHEDYISG MTFASDSMKL
160 170 180 190 200
VVTSGDGTLS VCNLRTSKVQ SQSEFSEDEL LSVVIMKNGR KVICGTQNGT
210 220 230 240 250
LLLYSWGFFK DCSDRFVDLA PNSVDALLKL DEDRLITGCD NGIISLVGIL
260 270 280 290 300
PNRIIQPIGS HDYPIEDLAL SHDKKFLGST AHDSMLKLWN LEEILEGSNV
310 320 330 340 350
NSGNASGAAE DSDSDNDGMD LDNDPSKSSK GSKRKTKSKA NTLNATNNFF

ADL
Length:353
Mass (Da):38,426
Last modified:June 1, 2002 - v2
Checksum:iAC72726AD631D581
GO
Isoform 2 (identifier: O80775-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: MEIDLGANAFGIDFHPSTNLVAAGLIDGHLHLYRYDSDSSLVRERKVRAHKESCRAVRFIDDGQR → MFFCWVLG

Show »
Length:296
Mass (Da):32,087
Checksum:i1E1EC4D5C91F8E30
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0578671 – 65MEIDL…DDGQR → MFFCWVLG in isoform 2. Add BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004481 Genomic DNA. Translation: AAC27402.2.
CP002685 Genomic DNA. Translation: AEC08945.1.
CP002685 Genomic DNA. Translation: AEC08946.1.
AK117481 mRNA. Translation: BAC42145.1.
BT005438 mRNA. Translation: AAO63858.1.
AY087666 mRNA. Translation: AAM65204.1.
PIRiT02314.
RefSeqiNP_565782.1. NM_128977.4. [O80775-1]
NP_973596.1. NM_201867.2. [O80775-2]
UniGeneiAt.37828.

Genome annotation databases

EnsemblPlantsiAT2G34260.1; AT2G34260.1; AT2G34260. [O80775-1]
AT2G34260.2; AT2G34260.2; AT2G34260. [O80775-2]
GeneIDi817987.
GrameneiAT2G34260.1; AT2G34260.1; AT2G34260.
AT2G34260.2; AT2G34260.2; AT2G34260.
KEGGiath:AT2G34260.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004481 Genomic DNA. Translation: AAC27402.2.
CP002685 Genomic DNA. Translation: AEC08945.1.
CP002685 Genomic DNA. Translation: AEC08946.1.
AK117481 mRNA. Translation: BAC42145.1.
BT005438 mRNA. Translation: AAO63858.1.
AY087666 mRNA. Translation: AAM65204.1.
PIRiT02314.
RefSeqiNP_565782.1. NM_128977.4. [O80775-1]
NP_973596.1. NM_201867.2. [O80775-2]
UniGeneiAt.37828.

3D structure databases

ProteinModelPortaliO80775.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G34260.1.

PTM databases

iPTMnetiO80775.

Proteomic databases

PaxDbiO80775.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G34260.1; AT2G34260.1; AT2G34260. [O80775-1]
AT2G34260.2; AT2G34260.2; AT2G34260. [O80775-2]
GeneIDi817987.
GrameneiAT2G34260.1; AT2G34260.1; AT2G34260.
AT2G34260.2; AT2G34260.2; AT2G34260.
KEGGiath:AT2G34260.

Organism-specific databases

TAIRiAT2G34260.

Phylogenomic databases

eggNOGiKOG2444. Eukaryota.
ENOG410ZHU5. LUCA.
HOGENOMiHOG000242496.
InParanoidiO80775.
OMAiYTHHFDF.
OrthoDBiEOG09360HMC.
PhylomeDBiO80775.

Miscellaneous databases

PROiO80775.

Gene expression databases

ExpressionAtlasiO80775. baseline and differential.
GenevisibleiO80775. AT.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR017422. WDR55.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038169. WD_repeat_p55. 1 hit.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR55_ARATH
AccessioniPrimary (citable) accession number: O80775
Secondary accession number(s): F4IGY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Plants with a weak allele homozygous for WDR55 display pleiotropic phenotypes in the seedling and adult stages.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.