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Protein

Short-chain dehydrogenase reductase 3a

Gene

SDR3a

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Confers resistance to the incompatible pathogenic bacteria P.syringae pv. tomato DC3000 in a PR1-dependent manner. Seems not involved in abscisic acid (ABA) biosynthesis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144SubstrateBy similarity1
Active sitei157Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 36NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • defense response to bacterium Source: TAIR
  • plant-type hypersensitive response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Hypersensitive response, Plant defense

Enzyme and pathway databases

BioCyciARA:AT2G47130-MONOMER.
ReactomeiR-ATH-193144. Estrogen biosynthesis.
R-ATH-2142700. Synthesis of Lipoxins (LX).
R-ATH-70895. Branched-chain amino acid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain dehydrogenase reductase 3a (EC:1.1.1.-)
Short name:
AtSDR3a
Gene namesi
Name:SDR3a
Synonyms:SDR3, SDR4
Ordered Locus Names:At2g47130
ORF Names:F14M4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G47130.

Pathology & Biotechi

Disruption phenotypei

No phenotype regarding abiotic stresses. Enhanced susceptibility to the incompatible pathogenic bacteria Pseudomonas syringae pv. tomato DC3000.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004195111 – 257Short-chain dehydrogenase reductase 3aAdd BLAST257

Proteomic databases

PaxDbiO80713.

Expressioni

Tissue specificityi

Highly expressed in the radicle tip, lateral root primordia and tips, and the area surrounding the cotyledon hydathode of young seedlings.1 Publication

Inductioni

Accumulates upon Pseudomonas syringae infection and after treatment with systemic acquired resistance (SAR)-inducing chemicals, 1,2-benzisothiazol-3(2H)-one1,1-dioxide (BIT) and benzo-(1,2,3)thiadiazole-7-carbothioic acid S-methyl ester (BTH).1 Publication

Gene expression databases

GenevisibleiO80713. AT.

Interactioni

Protein-protein interaction databases

BioGridi4661. 2 interactors.
IntActiO80713. 1 interactor.
STRINGi3702.AT2G47130.1.

Structurei

3D structure databases

ProteinModelPortaliO80713.
SMRiO80713.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
OMAiNGRTREK.
OrthoDBiEOG09360JOY.
PhylomeDBiO80713.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

O80713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLRLDGKI AIITGGASGI GAEAVRLFTD HGAKVVIVDF QEELGQNVAV
60 70 80 90 100
SVGKDKASFY RCDVTNEKEV ENAVKFTVEK YGKLDVLFSN AGVMEQPGSF
110 120 130 140 150
LDLNLEQFDR TMAVNVRGAA AFIKHAARAM VEKGTRGSIV CTTSVASEIG
160 170 180 190 200
GPGPHAYTAS KHALLGLVKS ACGGLGKYGI RVNGVAPYAV ATAINSRDEE
210 220 230 240 250
TVRMVEEYSA ATGILKGVVL KARHVAEAAL FLASDDSAYV SGQNLAVDGG

YSVVKPI
Length:257
Mass (Da):26,901
Last modified:November 1, 1998 - v1
Checksum:iF2853B98034728A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004411 Genomic DNA. Translation: AAC34217.1.
CP002685 Genomic DNA. Translation: AEC10805.1.
BT010410 mRNA. Translation: AAQ62411.1.
AK175374 mRNA. Translation: BAD43137.1.
PIRiT02175.
RefSeqiNP_182235.1. NM_130281.5.
UniGeneiAt.43807.
At.69627.

Genome annotation databases

EnsemblPlantsiAT2G47130.1; AT2G47130.1; AT2G47130.
GeneIDi819326.
GrameneiAT2G47130.1; AT2G47130.1; AT2G47130.
KEGGiath:AT2G47130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004411 Genomic DNA. Translation: AAC34217.1.
CP002685 Genomic DNA. Translation: AEC10805.1.
BT010410 mRNA. Translation: AAQ62411.1.
AK175374 mRNA. Translation: BAD43137.1.
PIRiT02175.
RefSeqiNP_182235.1. NM_130281.5.
UniGeneiAt.43807.
At.69627.

3D structure databases

ProteinModelPortaliO80713.
SMRiO80713.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4661. 2 interactors.
IntActiO80713. 1 interactor.
STRINGi3702.AT2G47130.1.

Proteomic databases

PaxDbiO80713.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G47130.1; AT2G47130.1; AT2G47130.
GeneIDi819326.
GrameneiAT2G47130.1; AT2G47130.1; AT2G47130.
KEGGiath:AT2G47130.

Organism-specific databases

TAIRiAT2G47130.

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
OMAiNGRTREK.
OrthoDBiEOG09360JOY.
PhylomeDBiO80713.

Enzyme and pathway databases

BioCyciARA:AT2G47130-MONOMER.
ReactomeiR-ATH-193144. Estrogen biosynthesis.
R-ATH-2142700. Synthesis of Lipoxins (LX).
R-ATH-70895. Branched-chain amino acid catabolism.

Miscellaneous databases

PROiO80713.

Gene expression databases

GenevisibleiO80713. AT.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSDR3A_ARATH
AccessioniPrimary (citable) accession number: O80713
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.