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Protein

Short-chain dehydrogenase reductase 3a

Gene

SDR3a

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Confers resistance to the incompatible pathogenic bacteria P.syringae pv. tomato DC3000 in a PR1-dependent manner. Seems not involved in abscisic acid (ABA) biosynthesis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144SubstrateBy similarity1
Active sitei157Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 36NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • defense response to bacterium Source: TAIR
  • plant-type hypersensitive response Source: UniProtKB-KW

Keywordsi

Molecular functionOxidoreductase
Biological processHypersensitive response, Plant defense

Enzyme and pathway databases

BioCyciARA:AT2G47130-MONOMER
ReactomeiR-ATH-77111 Synthesis of Ketone Bodies

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain dehydrogenase reductase 3a (EC:1.1.1.-)
Short name:
AtSDR3a
Gene namesi
Name:SDR3a
Synonyms:SDR3, SDR4
Ordered Locus Names:At2g47130
ORF Names:F14M4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G47130
TAIRilocus:2041439 AT2G47130

Pathology & Biotechi

Disruption phenotypei

No phenotype regarding abiotic stresses. Enhanced susceptibility to the incompatible pathogenic bacteria Pseudomonas syringae pv. tomato DC3000.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004195111 – 257Short-chain dehydrogenase reductase 3aAdd BLAST257

Proteomic databases

PaxDbiO80713

Expressioni

Tissue specificityi

Highly expressed in the radicle tip, lateral root primordia and tips, and the area surrounding the cotyledon hydathode of young seedlings.1 Publication

Inductioni

Accumulates upon Pseudomonas syringae infection and after treatment with systemic acquired resistance (SAR)-inducing chemicals, 1,2-benzisothiazol-3(2H)-one1,1-dioxide (BIT) and benzo-(1,2,3)thiadiazole-7-carbothioic acid S-methyl ester (BTH).1 Publication

Gene expression databases

ExpressionAtlasiO80713 baseline and differential
GenevisibleiO80713 AT

Interactioni

Protein-protein interaction databases

BioGridi4661, 2 interactors
IntActiO80713, 1 interactor
STRINGi3702.AT2G47130.1

Structurei

3D structure databases

ProteinModelPortaliO80713
SMRiO80713
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725 Eukaryota
COG1028 LUCA
OMAiINVHGAF
OrthoDBiEOG09360JOY
PhylomeDBiO80713

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

O80713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLRLDGKI AIITGGASGI GAEAVRLFTD HGAKVVIVDF QEELGQNVAV
60 70 80 90 100
SVGKDKASFY RCDVTNEKEV ENAVKFTVEK YGKLDVLFSN AGVMEQPGSF
110 120 130 140 150
LDLNLEQFDR TMAVNVRGAA AFIKHAARAM VEKGTRGSIV CTTSVASEIG
160 170 180 190 200
GPGPHAYTAS KHALLGLVKS ACGGLGKYGI RVNGVAPYAV ATAINSRDEE
210 220 230 240 250
TVRMVEEYSA ATGILKGVVL KARHVAEAAL FLASDDSAYV SGQNLAVDGG

YSVVKPI
Length:257
Mass (Da):26,901
Last modified:November 1, 1998 - v1
Checksum:iF2853B98034728A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004411 Genomic DNA Translation: AAC34217.1
CP002685 Genomic DNA Translation: AEC10805.1
BT010410 mRNA Translation: AAQ62411.1
AK175374 mRNA Translation: BAD43137.1
PIRiT02175
RefSeqiNP_182235.1, NM_130281.5
UniGeneiAt.43807
At.69627

Genome annotation databases

EnsemblPlantsiAT2G47130.1; AT2G47130.1; AT2G47130
GeneIDi819326
GrameneiAT2G47130.1; AT2G47130.1; AT2G47130
KEGGiath:AT2G47130

Similar proteinsi

Entry informationi

Entry nameiSDR3A_ARATH
AccessioniPrimary (citable) accession number: O80713
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health