ID   DAPB1_ARATH             Reviewed;         347 AA.
AC   O80574;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 2.
DT   16-JUN-2009, entry version 52.
DE   RecName: Full=Dihydrodipicolinate reductase 1, chloroplastic;
DE            Short=DHPR 1;
DE            EC=1.3.1.26;
DE   Flags: Precursor;
GN   Name=DAPB1; OrderedLocusNames=At2g44040; ORFNames=F6E13.17;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=20083487; PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
RA   Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
RA   Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
RA   Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
RA   Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
RA   Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=22954850; PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA   Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA   Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA   Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA   Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA   Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA   Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA   Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA   Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA   Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA   Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA   Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=21932900; PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M.,
RA   Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T.,
RA   Shibata K., Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [5]
RP   FUNCTION.
RX   PubMed=15652176; DOI=10.1016/j.bbagen.2004.09.008;
RA   Hudson A.O., Bless C., Macedo P., Chatterjee S.P., Singh B.K.,
RA   Gilvarg C., Leustek T.;
RT   "Biosynthesis of lysine in plants: evidence for a variant of the known
RT   bacterial pathways.";
RL   Biochim. Biophys. Acta 1721:27-36(2005).
CC   -!- CATALYTIC ACTIVITY: 2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) =
CC       2,3-dihydrodipicolinate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast (Potential).
CC   -!- SIMILARITY: Belongs to the dihydrodipicolinate reductase family.
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DR   EMBL; AC004005; AAC23412.2; -; Genomic_DNA.
DR   EMBL; BT008540; AAP40367.1; -; mRNA.
DR   EMBL; AY084299; AAM60890.1; -; mRNA.
DR   EMBL; AK118845; BAC43434.1; -; mRNA.
DR   IPI; IPI00545380; -.
DR   PIR; T00684; T00684.
DR   RefSeq; NP_566006.1; -.
DR   UniGene; At.36804; -.
DR   PRIDE; O80574; -.
DR   GeneID; 819009; -.
DR   GenomeReviews; CT485783_GR; AT2G44040.
DR   KEGG; ath:AT2G44040; -.
DR   NMPDR; fig|3702.1.peg.11571; -.
DR   TAIR; At2g44040; -.
DR   BRENDA; 1.3.1.26; 302.
DR   ArrayExpress; O80574; -.
DR   GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0008839; F:dihydrodipicolinate reductase activity; IGI:TAIR.
DR   GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000846; DapB.
DR   InterPro; IPR011770; DapB_bac/pln.
DR   InterPro; IPR011859; Dihydrodipicolinate_Rdtase_pln.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR20836; DapB_bac/pln; 1.
DR   Pfam; PF01113; DapB_N; 1.
DR   ProDom; PD004105; DapB; 1.
DR   TIGRFAMs; TIGR02130; dapB_plant; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; Chloroplast; Complete proteome;
KW   Diaminopimelate biosynthesis; Lysine biosynthesis; NADP;
KW   Oxidoreductase; Plastid; Transit peptide.
FT   TRANSIT       1     54       Chloroplast (Potential).
FT   CHAIN        55    347       Dihydrodipicolinate reductase 1,
FT                                chloroplastic.
FT                                /FTId=PRO_0000307182.
SQ   SEQUENCE   347 AA;  37550 MW;  0CE2DD95A2AA8072 CRC64;
     MATNGLMASS SVFLHRPRIA FASRTNQTVG KYGKGRVSFM GIGTRRLPVV LSMTAMADSG
     EEAVKSVLPG NGISIMVNGC SGKMGKAVIK AADSAGVNIV PISFGSAGED GQRVEVCGKE
     ITVHGPTERE KVLSSVFEKH PELIVVDYTI PSAVNDNAEL YSKVGVPFVM GTTGGDRNKL
     YETVEEAKIY AVISPQMGKQ VVAFLAAMEI MAEQFPGAFS GYSLDVMESH QASKLDASGT
     AKAVISCFQE LGVSYDMDQI QLIRDPKQQV EMVGVPEEHI SGHAFHLYHL TSPDETVSFE
     FQHNVCGRSI YAEGTVDAVL FLAKKIRLKA DQRIYNMIDV LREGNMR
//