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Protein

Ras-related protein RABH1b

Gene

RABH1B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Binds GTP and GDP and possesses intrinsic GTPase activity (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238GTPBy similarity
Nucleotide bindingi64 – 685GTPBy similarity
Nucleotide bindingi122 – 1254GTP
Nucleotide bindingi152 – 1532GTPBy similarity

GO - Molecular functioni

  • GTP binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein RABH1b
Short name:
AtRABH1b
Alternative name(s):
Ras-related protein Rab6A
Short name:
AtRab6A
Gene namesi
Name:RABH1B
Synonyms:RAB6A
Ordered Locus Names:At2g44610
ORF Names:F16B22.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G44610.

Subcellular locationi

  • Golgi apparatus membrane 1 Publication; Lipid-anchor 1 Publication
  • Cytoplasmcytosol 1 Publication

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • endosome Source: TAIR
  • Golgi apparatus Source: TAIR
  • Golgi membrane Source: UniProtKB
  • membrane Source: TAIR
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
  • trans-Golgi network Source: TAIR
  • vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi23 – 231T → N: Loss of GTP-binding activity. No effect on targeting to Golgi. 1 Publication
Mutagenesisi68 – 681Q → L: No effect on GTP-binding activity and targeting to Golgi. 1 Publication
Mutagenesisi122 – 1221N → I: Loss of GTP-binding activity and targeting to Golgi. Loss of GTP-binding activity; when associated with 206-C--C-208 Del. 2 Publications
Mutagenesisi206 – 2083Missing : No effect on GTP-binding activity. Loss of GTP-binding activity; when associated with I-122. 1 Publication
Mutagenesisi206 – 2061C → S: Loss of targeting to Golgi; when associated with S-208. 1 Publication
Mutagenesisi208 – 2081C → S: Loss of targeting to Golgi; when associated with S-206. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 208207Ras-related protein RABH1bPRO_0000348542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi206 – 2061S-geranylgeranyl cysteineBy similarity
Modified residuei208 – 2081Cysteine methyl esterBy similarity
Lipidationi208 – 2081S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiO80501.
PRIDEiO80501.

PTM databases

iPTMnetiO80501.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves and flowers.1 Publication

Gene expression databases

GenevisibleiO80501. AT.

Interactioni

Subunit structurei

Interacts with the C-terminus of GC5, but not with GC3.1 Publication

Protein-protein interaction databases

BioGridi4405. 4 interactions.
STRINGi3702.AT2G44610.1.

Structurei

3D structure databases

ProteinModelPortaliO80501.
SMRiO80501. Positions 9-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 469Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
HOGENOMiHOG000233968.
InParanoidiO80501.
KOiK07893.
OMAiPNIVIMN.
OrthoDBiEOG09360NEV.
PhylomeDBiO80501.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O80501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVSALAKY KLVFLGDQSV GKTSIITRFM YDKFDNTYQA TIGIDFLSKT
60 70 80 90 100
MYLEDRTVRL QLWDTAGQER FRSLIPSYIR DSSVAVIVYD VASRQSFLNT
110 120 130 140 150
TKWIDEVRTE RGSDVIVVLV GNKTDLVDKR QVSIEEAEAK ARELNVMFIE
160 170 180 190 200
TSAKAGFNIK ALFRKIAAAL PGMETLSSTK QEDMVDVNLK SSNANASLAQ

QQSGGCSC
Length:208
Mass (Da):23,130
Last modified:November 1, 1998 - v1
Checksum:iCD0EC2862AC7D0B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003672 Genomic DNA. Translation: AAC27463.1.
CP002685 Genomic DNA. Translation: AEC10447.1.
BT025780 mRNA. Translation: ABF83670.1.
AK226988 mRNA. Translation: BAE99055.1.
AY087904 mRNA. Translation: AAM65455.1.
PIRiT01588.
RefSeqiNP_181989.1. NM_130025.4.
UniGeneiAt.24965.

Genome annotation databases

EnsemblPlantsiAT2G44610.1; AT2G44610.1; AT2G44610.
GeneIDi819069.
GrameneiAT2G44610.1; AT2G44610.1; AT2G44610.
KEGGiath:AT2G44610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003672 Genomic DNA. Translation: AAC27463.1.
CP002685 Genomic DNA. Translation: AEC10447.1.
BT025780 mRNA. Translation: ABF83670.1.
AK226988 mRNA. Translation: BAE99055.1.
AY087904 mRNA. Translation: AAM65455.1.
PIRiT01588.
RefSeqiNP_181989.1. NM_130025.4.
UniGeneiAt.24965.

3D structure databases

ProteinModelPortaliO80501.
SMRiO80501. Positions 9-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4405. 4 interactions.
STRINGi3702.AT2G44610.1.

PTM databases

iPTMnetiO80501.

Proteomic databases

PaxDbiO80501.
PRIDEiO80501.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G44610.1; AT2G44610.1; AT2G44610.
GeneIDi819069.
GrameneiAT2G44610.1; AT2G44610.1; AT2G44610.
KEGGiath:AT2G44610.

Organism-specific databases

TAIRiAT2G44610.

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
HOGENOMiHOG000233968.
InParanoidiO80501.
KOiK07893.
OMAiPNIVIMN.
OrthoDBiEOG09360NEV.
PhylomeDBiO80501.

Enzyme and pathway databases

ReactomeiR-ATH-6811438. Intra-Golgi traffic.

Miscellaneous databases

PROiO80501.

Gene expression databases

GenevisibleiO80501. AT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAH1B_ARATH
AccessioniPrimary (citable) accession number: O80501
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.