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Protein

Ras-related protein RABH1b

Gene

RABH1B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Binds GTP and GDP and possesses intrinsic GTPase activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTPBy similarity8
Nucleotide bindingi64 – 68GTPBy similarity5
Nucleotide bindingi122 – 125GTP4
Nucleotide bindingi152 – 153GTPBy similarity2

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-6798695 Neutrophil degranulation
R-ATH-6811438 Intra-Golgi traffic
R-ATH-8854214 TBC/RABGAPs
R-ATH-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein RABH1b
Short name:
AtRABH1b
Alternative name(s):
Ras-related protein Rab6A
Short name:
AtRab6A
Gene namesi
Name:RABH1B
Synonyms:RAB6A
Ordered Locus Names:At2g44610
ORF Names:F16B22.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G44610
TAIRilocus:2042321 AT2G44610

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23T → N: Loss of GTP-binding activity. No effect on targeting to Golgi. 1 Publication1
Mutagenesisi68Q → L: No effect on GTP-binding activity and targeting to Golgi. 1 Publication1
Mutagenesisi122N → I: Loss of GTP-binding activity and targeting to Golgi. Loss of GTP-binding activity; when associated with 206-C--C-208 Del. 2 Publications1
Mutagenesisi206 – 208Missing : No effect on GTP-binding activity. Loss of GTP-binding activity; when associated with I-122. 1 Publication3
Mutagenesisi206C → S: Loss of targeting to Golgi; when associated with S-208. 1 Publication1
Mutagenesisi208C → S: Loss of targeting to Golgi; when associated with S-206. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003485421 – 208Ras-related protein RABH1bAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi206S-geranylgeranyl cysteineBy similarity1
Modified residuei208Cysteine methyl esterBy similarity1
Lipidationi208S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiO80501
PRIDEiO80501

PTM databases

iPTMnetiO80501

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves and flowers.1 Publication

Gene expression databases

ExpressionAtlasiO80501 baseline and differential
GenevisibleiO80501 AT

Interactioni

Subunit structurei

Interacts with the C-terminus of GC5, but not with GC3.1 Publication

Protein-protein interaction databases

BioGridi4405, 4 interactors
STRINGi3702.AT2G44610.1

Structurei

3D structure databases

ProteinModelPortaliO80501
SMRiO80501
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 46Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094 Eukaryota
ENOG410XPBI LUCA
HOGENOMiHOG000233968
InParanoidiO80501
KOiK07893
OMAiMYQATIG
OrthoDBiEOG09360NEV
PhylomeDBiO80501

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

O80501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVSALAKY KLVFLGDQSV GKTSIITRFM YDKFDNTYQA TIGIDFLSKT
60 70 80 90 100
MYLEDRTVRL QLWDTAGQER FRSLIPSYIR DSSVAVIVYD VASRQSFLNT
110 120 130 140 150
TKWIDEVRTE RGSDVIVVLV GNKTDLVDKR QVSIEEAEAK ARELNVMFIE
160 170 180 190 200
TSAKAGFNIK ALFRKIAAAL PGMETLSSTK QEDMVDVNLK SSNANASLAQ

QQSGGCSC
Length:208
Mass (Da):23,130
Last modified:November 1, 1998 - v1
Checksum:iCD0EC2862AC7D0B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003672 Genomic DNA Translation: AAC27463.1
CP002685 Genomic DNA Translation: AEC10447.1
BT025780 mRNA Translation: ABF83670.1
AK226988 mRNA Translation: BAE99055.1
AY087904 mRNA Translation: AAM65455.1
PIRiT01588
RefSeqiNP_181989.1, NM_130025.5
UniGeneiAt.24965

Genome annotation databases

EnsemblPlantsiAT2G44610.1; AT2G44610.1; AT2G44610
GeneIDi819069
GrameneiAT2G44610.1; AT2G44610.1; AT2G44610
KEGGiath:AT2G44610

Similar proteinsi

Entry informationi

Entry nameiRAH1B_ARATH
AccessioniPrimary (citable) accession number: O80501
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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