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O80448 (PDX11_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyridoxal biosynthesis protein PDX1.1
Alternative name(s):
HEVER-like protein
Short name=AtPDX1.1
Short name=AtPDX1;2
Gene names
Name:PDX11
Synonyms:PDX1L1
Ordered Locus Names:At2g38230
ORF Names:F16M14.16
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsrosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the production of pyridoxal (vitamin B6) and indirect resistance to singlet oxygen-generating photosensitizers. Ref.4

Pathway

Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.

Subunit structure

Homodimer or heterodimer with PDX1.2 or PDX1.3. Interacts with PDX2. Ref.5

Subcellular location

Cytoplasm Ref.4.

Tissue specificity

Expressed in flowers, shoots, leaves and weakly in roots. Ref.5

Post-translational modification

Ubiquitinated. Ref.6

Miscellaneous

In plants, synthesis of vitamin B6 does not involve deoxyxylulose 5-phosphate but utilizes intermediates from the pentose phosphate pathway and from glycolysis.

Vitamin B6 is an essential quencher of singlet oxygen in plants, that can protect cellular membranes from lipid peroxidation.

Sequence similarities

Belongs to the pdxS/SNZ family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Pyridoxal biosynthesis protein PDX1.1
PRO_0000109366

Sequences

Sequence LengthMass (Da)Tools
O80448 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 10D9EEDAEDC0BC4C

FASTA30932,862
        10         20         30         40         50         60 
MAGTGVVAVY GEGAMTETKQ KSPFSVKVGL AQMLRGGVIM DVVNAEQARI AEEAGACAVM 

        70         80         90        100        110        120 
ALERVPADIR AQGGVARMSD PEMIKEIKNA VTIPVMAKAR IGHFVEAQIL EAIGVDYVDE 

       130        140        150        160        170        180 
SEVLTLADED NHINKHNFKI PFVCGCRNLG EALRRIREGA AMIRTKGEAG TGNVVEAVRH 

       190        200        210        220        230        240 
VRSVNGAIRL LRSMDDDEVF TYAKKIAAPY DLVVQTKELG RLPVVQFAAG GVATPADAAL 

       250        260        270        280        290        300 
MMQLGCDGVF VGSGVFKSGD PVKRAKAIVQ AVTNYRDAAV LAEVSCGLGE AMVGLNLDDK 


VERFASRSE 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed: 10617197] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed: 14593172] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Vitamin B6 biosynthesis in higher plants."
Tambasco-Studart M., Titiz O., Raschle T., Forster G., Amrhein N., Fitzpatrick T.B.
Proc. Natl. Acad. Sci. U.S.A. 102:13687-13692(2005) [PubMed: 16157873] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis."
Wagner S., Bernhardt A., Leuendorf J.E., Drewke C., Lytovchenko A., Mujahed N., Gurgui C., Frommer W.B., Leistner E., Fernie A.R., Hellmann H.
Plant Cell 18:1722-1735(2006) [PubMed: 16766694] [Abstract]
Cited for: TISSUE SPECIFICITY, INTERACTION WITH PDX1.2; PDX1.3 AND PDX2.
Strain: cv. C24.
[6]"Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis."
Saracco S.A., Hansson M., Scalf M., Walker J.M., Smith L.M., Vierstra R.D.
Plant J. 59:344-358(2009) [PubMed: 19292762] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC003028 Genomic DNA. Translation: AAC27172.1.
CP002685 Genomic DNA. Translation: AEC09511.1.
AF370296 mRNA. Translation: AAK44111.1.
AF385694 mRNA. Translation: AAK60287.1.
AY063043 mRNA. Translation: AAL34217.1.
IPIIPI00534999.
PIRT01255.
RefSeqNP_181358.1. NM_129380.2.
UniGeneAt.48565.
At.68423.

3D structure databases

ProteinModelPortalO80448.
SMRO80448. Positions 24-292.
ModBaseSearch...

Protein-protein interaction databases

IntActO80448. 3 interactions.
STRINGO80448.

Proteomic databases

PRIDEO80448.
ProMEXO80448.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G38230.1; AT2G38230.1; AT2G38230.
GeneID818402.
GenomeReviewsGene locus AT2G38230 in contig CT485783_GR.
KEGGath:AT2G38230.
NMPDRfig|3702.1.peg.10935.

Organism-specific databases

TAIRAt2g38230.

Phylogenomic databases

eggNOGKOG1606.
GeneTreeEPGT00050000010473.
HOGENOMHBG292342.
InParanoidO80448.
OMAVEATYNF.
PhylomeDBO80448.
ProtClustDBCLSN2683112.

Enzyme and pathway databases

BioCycARA:AT2G38230-MONOMER.
MetaCyc:AT2G38230-MONOMER.

Gene expression databases

GenevestigatorO80448.
GermOnlineAT2G38230. Arabidopsis thaliana.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR001852. Snz1p/Sor1.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 2 hits.
KOK06215.
PANTHERPTHR22854:SF9. PTHR22854:SF9. 1 hit.
PfamPF01680. SOR_SNZ. 1 hit.
[Graphical view]
PIRSFPIRSF029271. Pdx1. 1 hit.
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMsTIGR00343. TIGR00343. 1 hit.
PROSITEPS01235. PDXS_SNZ_1. 1 hit.
PS51129. PDXS_SNZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDX11_ARATH
AccessionPrimary (citable) accession number: O80448
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: November 1, 1998
Last modified: November 16, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Recent format changes

Overview of recent format changes

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families