O80448 (PDX11_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyridoxal biosynthesis protein PDX1.1

Alternative name(s):
HEVER-like protein
Short name=AtPDX1.1
Short name=AtPDX1;2

Gene names

Name:	PDX11
Synonyms:	PDX1L1
Ordered Locus Names:	At2g38230
ORF Names:	F16M14.16

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the production of pyridoxal (vitamin B6) and indirect resistance to singlet oxygen-generating photosensitizers. Ref.4
Pathway	Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.
Subunit structure	Homodimer or heterodimer with PDX1.2 or PDX1.3. Interacts with PDX2. Ref.5
Subcellular location	Cytoplasm Ref.4.
Tissue specificity	Expressed in flowers, shoots, leaves and weakly in roots. Ref.5
Post-translational modification	Ubiquitinated. Ref.6
Miscellaneous	In plants, synthesis of vitamin B6 does not involve deoxyxylulose 5-phosphate but utilizes intermediates from the pentose phosphate pathway and from glycolysis. Vitamin B6 is an essential quencher of singlet oxygen in plants, that can protect cellular membranes from lipid peroxidation.
Sequence similarities	Belongs to the pdxS/SNZ family.

Ontologies

Keywords
Biological process	Pyridoxine biosynthesis
Cellular component	Cytoplasm
PTM	Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pyridoxal phosphate biosynthetic process Inferred from electronic annotation. Source: InterPro pyridoxine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast Inferred from direct assay. Source: TAIR cytosol Inferred from direct assay Ref.4. Source: TAIR
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro protein heterodimerization activity Inferred from physical interaction Ref.5. Source: TAIR
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Pyridoxal biosynthesis protein PDX1.1		PRO_0000109366

Sequences

	Sequence		Length	Mass (Da)
	O80448 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 10D9EEDAEDC0BC4C	FASTA	309	32,862
	10 20 30 40 50 60 MAGTGVVAVY GEGAMTETKQ KSPFSVKVGL AQMLRGGVIM DVVNAEQARI AEEAGACAVM 70 80 90 100 110 120 ALERVPADIR AQGGVARMSD PEMIKEIKNA VTIPVMAKAR IGHFVEAQIL EAIGVDYVDE 130 140 150 160 170 180 SEVLTLADED NHINKHNFKI PFVCGCRNLG EALRRIREGA AMIRTKGEAG TGNVVEAVRH 190 200 210 220 230 240 VRSVNGAIRL LRSMDDDEVF TYAKKIAAPY DLVVQTKELG RLPVVQFAAG GVATPADAAL 250 260 270 280 290 300 MMQLGCDGVF VGSGVFKSGD PVKRAKAIVQ AVTNYRDAAV LAEVSCGLGE AMVGLNLDDK VERFASRSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Vitamin B6 biosynthesis in higher plants." Tambasco-Studart M., Titiz O., Raschle T., Forster G., Amrhein N., Fitzpatrick T.B. Proc. Natl. Acad. Sci. U.S.A. 102:13687-13692(2005) [PubMed: 16157873] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]	"Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis." Wagner S., Bernhardt A., Leuendorf J.E., Drewke C., Lytovchenko A., Mujahed N., Gurgui C., Frommer W.B., Leistner E., Fernie A.R., Hellmann H. Plant Cell 18:1722-1735(2006) [PubMed: 16766694] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH PDX1.2; PDX1.3 AND PDX2. Strain: cv. C24.
[6]	"Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis." Saracco S.A., Hansson M., Scalf M., Walker J.M., Smith L.M., Vierstra R.D. Plant J. 59:344-358(2009) [PubMed: 19292762] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC003028 Genomic DNA. Translation: AAC27172.1. CP002685 Genomic DNA. Translation: AEC09511.1. AF370296 mRNA. Translation: AAK44111.1. AF385694 mRNA. Translation: AAK60287.1. AY063043 mRNA. Translation: AAL34217.1.
IPI	IPI00534999.
PIR	T01255.
RefSeq	NP_181358.1. NM_129380.2.
UniGene	At.48565. At.68423.
3D structure databases
ProteinModelPortal	O80448.
SMR	O80448. Positions 24-292.
ModBase	Search...
Protein-protein interaction databases
IntAct	O80448. 3 interactions.
STRING	O80448.
Proteomic databases
PRIDE	O80448.
ProMEX	O80448.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT2G38230.1; AT2G38230.1; AT2G38230.
GeneID	818402.
GenomeReviews	Gene locus AT2G38230 in contig CT485783_GR.
KEGG	ath:AT2G38230.
NMPDR	fig|3702.1.peg.10935.
Organism-specific databases
TAIR	At2g38230.
Phylogenomic databases
eggNOG	KOG1606.
GeneTree	EPGT00050000010473.
HOGENOM	HBG292342.
InParanoid	O80448.
OMA	VEATYNF.
PhylomeDB	O80448.
ProtClustDB	CLSN2683112.
Enzyme and pathway databases
BioCyc	ARA:AT2G38230-MONOMER. MetaCyc:AT2G38230-MONOMER.
Gene expression databases
Genevestigator	O80448.
GermOnline	AT2G38230. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR011060. RibuloseP-bd_barrel. IPR001852. Snz1p/Sor1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 2 hits.
KO	K06215.
PANTHER	PTHR22854:SF9. PTHR22854:SF9. 1 hit.
Pfam	PF01680. SOR_SNZ. 1 hit. [Graphical view]
PIRSF	PIRSF029271. Pdx1. 1 hit.
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMs	TIGR00343. TIGR00343. 1 hit.
PROSITE	PS01235. PDXS_SNZ_1. 1 hit. PS51129. PDXS_SNZ_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDX11_ARATH

Accession

Primary (citable) accession number: O80448

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	November 1, 1998
Last modified:	November 16, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program