Reviewed, UniProtKB/Swiss-Prot O80448 (PDX11_ARATH)

Names and origin

Protein names

Recommended name:
    Pyridoxal biosynthesis protein PDX1.1
Alternative name(s):
    HEVER-like protein
      Short name=AtPDX1.1
      Short name=AtPDX1;2

Gene names

Name:	PDX11
Synonyms:	PDX1L1
Ordered Locus Names:	At2g38230
ORF Names:	F16M14.16

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the production of pyridoxal (vitamin B6) and indirect resistance to singlet oxygen-generating photosensitizers. Ref.3
Pathway	Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.
Subunit structure	Homodimer or heterodimer with PDX1.2 or PDX1.3. Interacts with PDX2. Ref.4
Subcellular location	Cytoplasm. Ref.3
Tissue specificity	Expressed in flowers, shoots, leaves and weakly in roots. Ref.4
Miscellaneous	In plants, synthesis of vitamin B6 does not involve deoxyxylulose 5-phosphate but utilizes intermediates from the pentose phosphate pathway and from glycolysis. Vitamin B6 is an essential quencher of singlet oxygen in plants, that can protect cellular membranes from lipid peroxidation.
Sequence similarities	Belongs to the pdxS/SNZ family.

Ontologies

Keywords
Biological process	Pyridoxine biosynthesis
Cellular component	Cytoplasm
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridoxine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast Inferred from direct assay. Source: TAIR cytosol Ref.3 Inferred from direct assay. Source: TAIR
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro protein heterodimerization activity Ref.4 Inferred from physical interaction. Source: TAIR
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PDX12	Q9ZNR6	1	EBI-1545972,EBI-1545987

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Pyridoxal biosynthesis protein PDX1.1		PRO_0000109366

Sequences

	Sequence		Length	Mass (Da)
	O80448-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 10D9EEDAEDC0BC4C	FASTA	309	32,862
	10 20 30 40 50 60 MAGTGVVAVY GEGAMTETKQ KSPFSVKVGL AQMLRGGVIM DVVNAEQARI AEEAGACAVM 70 80 90 100 110 120 ALERVPADIR AQGGVARMSD PEMIKEIKNA VTIPVMAKAR IGHFVEAQIL EAIGVDYVDE 130 140 150 160 170 180 SEVLTLADED NHINKHNFKI PFVCGCRNLG EALRRIREGA AMIRTKGEAG TGNVVEAVRH 190 200 210 220 230 240 VRSVNGAIRL LRSMDDDEVF TYAKKIAAPY DLVVQTKELG RLPVVQFAAG GVATPADAAL 250 260 270 280 290 300 MMQLGCDGVF VGSGVFKSGD PVKRAKAIVQ AVTNYRDAAV LAEVSCGLGE AMVGLNLDDK VERFASRSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[3]	"Vitamin B6 biosynthesis in higher plants." Tambasco-Studart M., Titiz O., Raschle T., Forster G., Amrhein N., Fitzpatrick T.B. Proc. Natl. Acad. Sci. U.S.A. 102:13687-13692(2005) [PubMed: 16157873] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]	"Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis." Wagner S., Bernhardt A., Leuendorf J.E., Drewke C., Lytovchenko A., Mujahed N., Gurgui C., Frommer W.B., Leistner E., Fernie A.R., Hellmann H. Plant Cell 18:1722-1735(2006) [PubMed: 16766694] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH PDX1.2, PDX1.3 AND PDX2. Strain: cv. C24.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC003028 Genomic DNA. Translation: AAC27172.1. AF370296 mRNA. Translation: AAK44111.1. AF385694 mRNA. Translation: AAK60287.1. AY063043 mRNA. Translation: AAL34217.1.
IPI	IPI00534999.
PIR	T01255.
RefSeq	NP_181358.1.
UniGene	At.68423
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O80448. 3 interactions.
Proteomic databases
PRIDE	O80448.
ProMEX	O80448.
Genome annotation databases
GeneID	818402.
GenomeReviews	Gene locus AT2G38230 in contig CT485783_GR.
KEGG	ath:AT2G38230.
NMPDR	fig|3702.1.peg.10935.
Organism-specific databases
TAIR	At2g38230.
Phylogenomic databases
OMA	O80448. VGYKEMG.
Gene expression databases
GermOnline	AT2G38230. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR001852. Snz1p/Sor1. [Graphical view]
Pfam	PF01680. SOR_SNZ. 1 hit. [Graphical view]
PIRSF	PIRSF029271. Pdx1. 1 hit.
ProDom	PD004958. Snz1p/Sor1. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00343. Snz1p/Sor1. 1 hit.
PROSITE	PS01235. PDXS_SNZ_1. 1 hit. PS51129. PDXS_SNZ_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDX11_ARATH

Accession

Primary (citable) accession number: O80448

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)