Reviewed,
UniProtKB/Swiss-Prot O80434 (LAC4_ARATH)
Last modified
February 9, 2010.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Laccase-4 EC=1.10.3.2 Alternative name(s): Benzenediol:oxygen oxidoreductase 4 Urishiol oxidase 4 Diphenol oxidase 4 Protein IRREGULAR XYLEM 12 | ||||||||
| Gene names |
| ||||||||
| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 558 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Lignin degradation and detoxification of lignin-derived products By similarity. Required for secondary xylem cell wall lignification. Ref.3 |
| Catalytic activity | 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. |
| Cofactor | Binds 4 copper ions per monomer By similarity. |
| Subcellular location | Secreted › extracellular space › apoplast Potential. |
| Tissue specificity | Ubiquitous, with higher levels in the inflorescence stem. Ref.4 Ref.5 |
| Developmental stage | Transcript levels diminished during rosette leaves development. Ref.4 |
| Sequence similarities | Belongs to the multicopper oxidase family. Contains 3 plastocyanin-like domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lignin degradation |
| Cellular component | Apoplast Secreted |
| Domain | Repeat Signal |
| Ligand | Copper Metal-binding |
| Molecular function | Oxidoreductase |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | lignin catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW secondary cell wall biogenesis Ref.3Inferred from mutant phenotype. Source: TAIR |
| Cellular component | apoplast Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW laccase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 24 | 24 | Potential | ||||||
| Chain | 25 – 558 | 534 | Laccase-4 | PRO_0000283632 | |||||
Regions | |||||||||
| Domain | 32 – 148 | 117 | Plastocyanin-like 1 | ||||||
| Domain | 158 – 308 | 151 | Plastocyanin-like 2 | ||||||
| Domain | 408 – 542 | 135 | Plastocyanin-like 3 | ||||||
Sites | |||||||||
| Metal binding | 82 | 1 | Copper 1; type 2 By similarity | ||||||
| Metal binding | 84 | 1 | Copper 2; type 3 By similarity | ||||||
| Metal binding | 127 | 1 | Copper 2; type 3 By similarity | ||||||
| Metal binding | 129 | 1 | Copper 3; type 3 By similarity | ||||||
| Metal binding | 459 | 1 | Copper 4; type 1 By similarity | ||||||
| Metal binding | 462 | 1 | Copper 1; type 2 By similarity | ||||||
| Metal binding | 464 | 1 | Copper 3; type 3 By similarity | ||||||
| Metal binding | 521 | 1 | Copper 3; type 3 By similarity | ||||||
| Metal binding | 522 | 1 | Copper 4; type 1 By similarity | ||||||
| Metal binding | 523 | 1 | Copper 2; type 3 By similarity | ||||||
| Metal binding | 527 | 1 | Copper 4; type 1 By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 37 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 78 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 114 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 187 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 296 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 323 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 330 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 373 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 383 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 400 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 418 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 441 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 479 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 545 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AC003028 Genomic DNA. Translation: AAC27158.2. AY052669 mRNA. Translation: AAK96573.1. AY063730 mRNA. Translation: AAL36080.1. AY065187 mRNA. Translation: AAL38363.1. AY114636 mRNA. Translation: AAM47955.1. |
| IPI | IPI00522344. |
| PIR | T01240. |
| RefSeq | NP_565881.1. |
| UniGene | At.12454 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | O80434. |
Genome annotation databases | |
| GeneID | 818386. |
| GenomeReviews | Gene locus AT2G38080 in contig CT485783_GR. |
| KEGG | ath:AT2G38080. |
| NMPDR | fig|3702.1.peg.10916. |
Organism-specific databases | |
| TAIR | At2g38080. |
Phylogenomic databases | |
| eggNOG | KOG1263. |
| HOGENOM | HBG749556. |
| InParanoid | O80434. |
| OMA | YAREDDT. |
| PhylomeDB | O80434. |
Enzyme and pathway databases | |
| BRENDA | 1.10.3.2. 302. |
Gene expression databases | |
| ArrayExpress | O80434. |
| Genevestigator | O80434. |
Family and domain databases | |
| InterPro | IPR001117. Cu-oxidase. IPR011706. Cu-oxidase_2. IPR011707. Cu-oxidase_3. IPR002355. Cu_oxidase_Cu_BS. IPR008972. Cupredoxin. IPR017761. Laccase. [Graphical view] |
| Gene3D | G3DSA:2.60.40.420. Cupredoxin. 3 hits. |
| Pfam | PF00394. Cu-oxidase. 1 hit. PF07731. Cu-oxidase_2. 1 hit. PF07732. Cu-oxidase_3. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03389. laccase. 1 hit. |
| PROSITE | PS00079. MULTICOPPER_OXIDASE1. 1 hit. PS00080. MULTICOPPER_OXIDASE2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LAC4_ARATH | ||||||||
| Accession | Primary (citable) accession number: O80434 Secondary accession number(s): Q940U7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


