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O80433

- CISY_DAUCA

UniProt

O80433 - CISY_DAUCA

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Protein

Citrate synthase, mitochondrial

Gene

CS

Organism
Daucus carota (Wild carrot)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei308 – 3081PROSITE-ProRule annotation
Active sitei354 – 3541PROSITE-ProRule annotation
Active sitei409 – 4091PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15824.
BRENDAi2.3.3.1. 1841.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.16)
Gene namesi
Name:CS
OrganismiDaucus carota (Wild carrot)
Taxonomic identifieri4039 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsApialesApiaceaeApioideaeScandiceaeDaucinaeDaucus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 472Citrate synthase, mitochondrialPRO_0000005487
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PRIDEiO80433.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO80433.
SMRiO80433. Positions 36-464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O80433-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVFFRSVSLL NKLRSRAVQQ SNLSNTVRWF QVQTSASDLD LRSQLKELIP
60 70 80 90 100
EQQERIKKLK AEHGKVQLGN ITVDMVLGGM RGMTGLLWET SLLDPEEGIR
110 120 130 140 150
FRGLSIPECQ KLLPGAKPGG EPLPEGLLWL LLTGKVPTKE QVDALSAELR
160 170 180 190 200
SRAAVPEHVY KTIDALPVTA HPMTQFATGV MALQVQSEFQ KAYEKGIHKT
210 220 230 240 250
KYWEPTYEDS ITLIAQLPVV AAYIYRRMYK NGQSISTDDS LDYGANFAHM
260 270 280 290 300
LGYDSPSMQE LMRLYVTIHT DHEGGNVSAH TGHLVASALS DPYLSFAAAL
310 320 330 340 350
NGLAGPLHGL ANQEVLLWIK SVVSECGENV TKEQLKDYIW KTLNSGKVVP
360 370 380 390 400
GYGHGVLRNT DPRYICQREF ALKHLPDDPL FQLVSNLFEV VPPILTELGK
410 420 430 440 450
VKNPWPNVDA HSGVLLNHYG LTEARYYTVL FGVSRAIGIC SQLVWDRALG
460 470
LPLERPKSVT MEWLENHCKK SS
Length:472
Mass (Da):52,657
Last modified:November 1, 1998 - v1
Checksum:iA6C8CFCA17142120
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017159 mRNA. Translation: BAA32557.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017159 mRNA. Translation: BAA32557.1 .

3D structure databases

ProteinModelPortali O80433.
SMRi O80433. Positions 36-464.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O80433.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BioCyci MetaCyc:MONOMER-15824.
BRENDAi 2.3.3.1. 1841.

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA encoding carrot mitochondrial citrate synthase."
    Takita E., Koyama H., Shirano Y., Shibata D., Hara T.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. MS Yonsun.

Entry informationi

Entry nameiCISY_DAUCA
AccessioniPrimary (citable) accession number: O80433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3