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Protein

Ethylene-responsive transcription factor 4

Gene

ERF4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways, and could also regulate other AtERFs.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi24 – 81AP2/ERFPROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

  • DNA binding transcription factor activity Source: TAIR
  • sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • ethylene-activated signaling pathway Source: UniProtKB-KW
  • induced systemic resistance, jasmonic acid mediated signaling pathway Source: TAIR
  • negative regulation of ethylene-activated signaling pathway Source: TAIR
  • negative regulation of transcription, DNA-templated Source: TAIR
  • response to abscisic acid Source: TAIR
  • response to chitin Source: TAIR
  • response to ethylene Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processEthylene signaling pathway, Plant defense, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene-responsive transcription factor 4
Short name:
AtERF4
Alternative name(s):
Ethylene-responsive element-binding factor 4
Short name:
EREBP-4
Protein RELATED TO APETALA2 5
Gene namesi
Name:ERF4
Synonyms:ERF-4, ERF078, RAP2-5
Ordered Locus Names:At3g15210
ORF Names:K7L4.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G15210
TAIRilocus:2087065 AT3G15210

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001125541 – 222Ethylene-responsive transcription factor 4Add BLAST222

Proteomic databases

PaxDbiO80340

Expressioni

Inductioni

Induced by jasmonate (JA) and by Alternaria brassicicola (locally and systemically), but only slightly by ethylene. Strong induction by wounding, cold or drought stress does not require EIN2, whereas induction by NaCl does. Transcripts accumulate in cycloheximide-treated plants, a protein synthesis inhibitor. Seems to not be influenced by exogenous abscisic acid (ABA), and heat stress.2 Publications

Gene expression databases

ExpressionAtlasiO80340 baseline and differential
GenevisibleiO80340 AT

Interactioni

Subunit structurei

Interacts with SAP18.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi6086, 7 interactors
IntActiO80340, 34 interactors
STRINGi3702.AT3G15210.1

Structurei

3D structure databases

ProteinModelPortaliO80340
SMRiO80340
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi211 – 217EAR-like (transcriptional repression)7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 137Poly-Gly6

Domaini

Contains a slightly degenerated ERF-associated amphiphilic repression (EAR) motif, which may be involved in the activity of transcriptional repression.1 Publication

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J0HH Eukaryota
ENOG410YQ8J LUCA
HOGENOMiHOG000237624
InParanoidiO80340
KOiK09286
OMAiDCASPPT
OrthoDBiEOG09360Q3E
PhylomeDBiO80340

Family and domain databases

CDDicd00018 AP2, 1 hit
Gene3Di3.30.730.10, 1 hit
InterProiView protein in InterPro
IPR001471 AP2/ERF_dom
IPR036955 AP2/ERF_dom_sf
IPR016177 DNA-bd_dom_sf
PfamiView protein in Pfam
PF00847 AP2, 1 hit
PRINTSiPR00367 ETHRSPELEMNT
SMARTiView protein in SMART
SM00380 AP2, 1 hit
SUPFAMiSSF54171 SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS51032 AP2_ERF, 1 hit

Sequencei

Sequence statusi: Complete.

O80340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKMGLKPDP ATTNQTHNNA KEIRYRGVRK RPWGRYAAEI RDPGKKTRVW
60 70 80 90 100
LGTFDTAEEA ARAYDTAARD FRGAKAKTNF PTFLELSDQK VPTGFARSPS
110 120 130 140 150
QSSTLDCASP PTLVVPSATA GNVPPQLELS LGGGGGGSCY QIPMSRPVYF
160 170 180 190 200
LDLMGIGNVG RGQPPPVTSA FRSPVVHVAT KMACGAQSDS DSSSVVDFEG
210 220
GMEKRSQLLD LDLNLPPPSE QA
Length:222
Mass (Da):23,741
Last modified:November 1, 1998 - v1
Checksum:iCEF16ABA5ACFB073
GO

Sequence cautioni

The sequence AAC49771 differs from that shown. Reason: Frameshift at position 208.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003098 mRNA Translation: AAC49771.1 Frameshift.
AB008106 mRNA Translation: BAA32421.1
AP000413 Genomic DNA Translation: BAB02150.1
CP002686 Genomic DNA Translation: AEE75632.1
AY140030 mRNA Translation: AAM98171.1
BT010325 mRNA Translation: AAQ55276.1
AY086232 mRNA Translation: AAM64308.1
PIRiT52019
RefSeqiNP_188139.1, NM_112384.2
UniGeneiAt.47551

Genome annotation databases

EnsemblPlantsiAT3G15210.1; AT3G15210.1; AT3G15210
GeneIDi820752
GrameneiAT3G15210.1; AT3G15210.1; AT3G15210
KEGGiath:AT3G15210

Similar proteinsi

Entry informationi

Entry nameiERF78_ARATH
AccessioniPrimary (citable) accession number: O80340
Secondary accession number(s): O23107, Q53XI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health