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Protein

Ethylene-responsive transcription factor 2

Gene

ERF2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. Involved in disease resistance pathways.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi116 – 174AP2/ERFPROSITE-ProRule annotationAdd BLAST59

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • cell division Source: TAIR
  • ethylene-activated signaling pathway Source: TAIR
  • induced systemic resistance, jasmonic acid mediated signaling pathway Source: TAIR
  • positive regulation of transcription, DNA-templated Source: TAIR
  • response to chitin Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
  • vasculature development Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Ethylene signaling pathway, Plant defense, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene-responsive transcription factor 2
Short name:
AtERF2
Alternative name(s):
Ethylene-responsive element-binding factor 2
Short name:
EREBP-2
Gene namesi
Name:ERF2
Synonyms:ERF-2, ERF101
Ordered Locus Names:At5g47220
ORF Names:MQL5.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G47220.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001125461 – 243Ethylene-responsive transcription factor 2Add BLAST243

Proteomic databases

PaxDbiO80338.

Expressioni

Inductioni

Induced by jasmonate (JA) and Alternaria brassicicola (locally and systemically). Ethylene induction is completely dependent on a functional ETHYLENE-INSENSITIVE2 (EIN2) while wounding induction does not require EIN2. Transcripts accumulate strongly in cycloheximide-treated plants, a protein synthesis inhibitor. Seems to not be influenced by exogenous abscisic acid (ABA), cold, heat, NaCl or drought stress.2 Publications

Gene expression databases

GenevisibleiO80338. AT.

Interactioni

Protein-protein interaction databases

BioGridi20016. 2 interactors.
STRINGi3702.AT5G47220.1.

Structurei

3D structure databases

ProteinModelPortaliO80338.
SMRiO80338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 26Poly-Gly4
Compositional biasi192 – 206Poly-SerAdd BLAST15

Domaini

The AP2/ERF domain binds specifically to the 5'-GCCGCC-3' motif. The affinity of this binding is higher if the seventh amino-acid of this domain is basic (By similarity).By similarity

Sequence similaritiesi

Contains 1 AP2/ERF DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IZGE. Eukaryota.
ENOG410YRS5. LUCA.
HOGENOMiHOG000239314.
InParanoidiO80338.
KOiK14517.
OMAiCLFDFPA.
OrthoDBiEOG09360POM.
PhylomeDBiO80338.

Family and domain databases

CDDicd00018. AP2. 1 hit.
Gene3Di3.30.730.10. 1 hit.
InterProiIPR001471. AP2/ERF_dom.
IPR016177. DNA-bd_dom.
[Graphical view]
PfamiPF00847. AP2. 1 hit.
[Graphical view]
PRINTSiPR00367. ETHRSPELEMNT.
SMARTiSM00380. AP2. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS51032. AP2_ERF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O80338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGQCNIESD YALLESITRH LLGGGGENEL RLNESTPSSC FTESWGGLPL
60 70 80 90 100
KENDSEDMLV YGLLKDAFHF DTSSSDLSCL FDFPAVKVEP TENFTAMEEK
110 120 130 140 150
PKKAIPVTET AVKAKHYRGV RQRPWGKFAA EIRDPAKNGA RVWLGTFETA
160 170 180 190 200
EDAALAYDIA AFRMRGSRAL LNFPLRVNSG EPDPVRITSK RSSSSSSSSS
210 220 230 240
SSTSSSENGK LKRRRKAENL TSEVVQVKCE VGDETRVDEL LVS
Length:243
Mass (Da):26,797
Last modified:November 1, 1998 - v1
Checksum:iC9A4C9791249B5D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168R → S in AAM64544 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008104 mRNA. Translation: BAA32419.1.
AB018117 Genomic DNA. Translation: BAA97155.1.
CP002688 Genomic DNA. Translation: AED95487.1.
AK175151 mRNA. Translation: BAD42914.1.
AK175229 mRNA. Translation: BAD42992.1.
AK176532 mRNA. Translation: BAD44295.1.
AK176606 mRNA. Translation: BAD44369.1.
AK176825 mRNA. Translation: BAD44588.1.
BT024470 mRNA. Translation: ABD19651.1.
AY086983 mRNA. Translation: AAM64544.1.
PIRiT51989.
RefSeqiNP_199533.1. NM_124093.3.
UniGeneiAt.19731.

Genome annotation databases

EnsemblPlantsiAT5G47220.1; AT5G47220.1; AT5G47220.
GeneIDi834768.
GrameneiAT5G47220.1; AT5G47220.1; AT5G47220.
KEGGiath:AT5G47220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008104 mRNA. Translation: BAA32419.1.
AB018117 Genomic DNA. Translation: BAA97155.1.
CP002688 Genomic DNA. Translation: AED95487.1.
AK175151 mRNA. Translation: BAD42914.1.
AK175229 mRNA. Translation: BAD42992.1.
AK176532 mRNA. Translation: BAD44295.1.
AK176606 mRNA. Translation: BAD44369.1.
AK176825 mRNA. Translation: BAD44588.1.
BT024470 mRNA. Translation: ABD19651.1.
AY086983 mRNA. Translation: AAM64544.1.
PIRiT51989.
RefSeqiNP_199533.1. NM_124093.3.
UniGeneiAt.19731.

3D structure databases

ProteinModelPortaliO80338.
SMRiO80338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi20016. 2 interactors.
STRINGi3702.AT5G47220.1.

Proteomic databases

PaxDbiO80338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G47220.1; AT5G47220.1; AT5G47220.
GeneIDi834768.
GrameneiAT5G47220.1; AT5G47220.1; AT5G47220.
KEGGiath:AT5G47220.

Organism-specific databases

TAIRiAT5G47220.

Phylogenomic databases

eggNOGiENOG410IZGE. Eukaryota.
ENOG410YRS5. LUCA.
HOGENOMiHOG000239314.
InParanoidiO80338.
KOiK14517.
OMAiCLFDFPA.
OrthoDBiEOG09360POM.
PhylomeDBiO80338.

Miscellaneous databases

PROiO80338.

Gene expression databases

GenevisibleiO80338. AT.

Family and domain databases

CDDicd00018. AP2. 1 hit.
Gene3Di3.30.730.10. 1 hit.
InterProiIPR001471. AP2/ERF_dom.
IPR016177. DNA-bd_dom.
[Graphical view]
PfamiPF00847. AP2. 1 hit.
[Graphical view]
PRINTSiPR00367. ETHRSPELEMNT.
SMARTiSM00380. AP2. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS51032. AP2_ERF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEF101_ARATH
AccessioniPrimary (citable) accession number: O80338
Secondary accession number(s): Q682Y8, Q8LBU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.