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Protein

Ethylene-responsive transcription factor 1A

Gene

ERF1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.3 Publications

Caution

Two different genes At3g23240 and At4g17500 were assigned the same gene name ERF1.Curated
It is uncertain whether Met-1 or Met-3 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi147 – 205AP2/ERFPROSITE-ProRule annotationAdd BLAST59

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: TAIR

GO - Biological processi

  • cell division Source: TAIR
  • defense response Source: UniProtKB-KW
  • ethylene-activated signaling pathway Source: UniProtKB-KW
  • phloem or xylem histogenesis Source: TAIR
  • response to chitin Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processEthylene signaling pathway, Plant defense, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene-responsive transcription factor 1A
Short name:
AtERF1A
Alternative name(s):
Ethylene-responsive element-binding factor 1A
Short name:
EREBP-1A
Gene namesi
Name:ERF1A
Synonyms:ERF-1, ERF100
Ordered Locus Names:At4g17500
ORF Names:dl4785w, FCAALL.123
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G17500
TAIRilocus:2129116 AT4G17500

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001125421 – 268Ethylene-responsive transcription factor 1AAdd BLAST268

Proteomic databases

PaxDbiO80337

Expressioni

Tissue specificityi

Ubiquitously expressed, mostly in flowers and rosettes after ethylene treatment.1 Publication

Inductioni

Induced by Pseudomonas syringae tomato (both virulent and avirulent avrRpt2 strains), independently of PAD4. Also induced by methyl jasmonate (MeJA) independently of JAR1. Ethylene induction is completely dependent on a functional ETHYLENE-INSENSITIVE2 (EIN2), whereas induction by wounding does not need EIN2. Induction by salicylic acid (SA) seems to be independent of PAD4 and NPR1. Transcripts accumulate strongly in cycloheximide-treated plants, a protein synthesis inhibitor. Seems to not be influenced by exogenous abscisic acid (ABA), cold, heat, NaCl or drought stress.2 Publications

Gene expression databases

ExpressionAtlasiO80337 baseline and differential
GenevisibleiO80337 AT

Interactioni

Protein-protein interaction databases

BioGridi12757, 1 interactor
STRINGi3702.AT4G17500.1

Structurei

Secondary structure

1268
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi151 – 154Combined sources4
Turni155 – 157Combined sources3
Beta strandi158 – 165Combined sources8
Turni166 – 169Combined sources4
Beta strandi170 – 180Combined sources11
Helixi181 – 196Combined sources16
Beta strandi203 – 206Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GCCNMR-A146-208[»]
2GCCNMR-A143-212[»]
3GCCNMR-A143-212[»]
ProteinModelPortaliO80337
SMRiO80337
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO80337

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi221 – 237Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi98 – 102Poly-Ser5

Domaini

The AP2/ERF domain binds specifically to the 5'-GCCGCC-3' motif. The affinity of this binding is higher if the seventh amino-acid of this domain is basic (By similarity).By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J07P Eukaryota
ENOG410YJV7 LUCA
HOGENOMiHOG000239314
InParanoidiO80337
KOiK09286
OMAiNETDLAM
OrthoDBiEOG09360R86
PhylomeDBiO80337

Family and domain databases

CDDicd00018 AP2, 1 hit
Gene3Di3.30.730.10, 1 hit
InterProiView protein in InterPro
IPR001471 AP2/ERF_dom
IPR036955 AP2/ERF_dom_sf
IPR016177 DNA-bd_dom_sf
PfamiView protein in Pfam
PF00847 AP2, 1 hit
PRINTSiPR00367 ETHRSPELEMNT
SMARTiView protein in SMART
SM00380 AP2, 1 hit
SUPFAMiSSF54171 SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS51032 AP2_ERF, 1 hit

Sequencei

Sequence statusi: Complete.

O80337-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMTADSQSD YAFLESIRRH LLGESEPILS ESTASSVTQS CVTGQSIKPV
60 70 80 90 100
YGRNPSFSKL YPCFTESWGD LPLKENDSED MLVYGILNDA FHGGWEPSSS
110 120 130 140 150
SSDEDRSSFP SVKIETPESF AAVDSVPVKK EKTSPVSAAV TAAKGKHYRG
160 170 180 190 200
VRQRPWGKFA AEIRDPAKNG ARVWLGTFET AEDAALAYDR AAFRMRGSRA
210 220 230 240 250
LLNFPLRVNS GEPDPVRIKS KRSSFSSSNE NGAPKKRRTV AAGGGMDKGL
260
TVKCEVVEVA RGDRLLVL
Length:268
Mass (Da):29,190
Last modified:May 27, 2002 - v2
Checksum:i0FB7839984E97B50
GO

Sequence cautioni

The sequence BAA32418 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB45963 differs from that shown. Reason: Frameshift at position 44.Curated
The sequence CAB78753 differs from that shown. Reason: Frameshift at position 44.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97343 Genomic DNA Translation: CAB45963.1 Frameshift.
AL161546 Genomic DNA Translation: CAB78753.1 Frameshift.
CP002687 Genomic DNA Translation: AEE83903.1
AY058174 mRNA Translation: AAL25588.1
AY062533 mRNA Translation: AAL32611.1
BT002578 mRNA Translation: AAO00938.1
AB008103 mRNA Translation: BAA32418.1 Different initiation.
PIRiA85196
T51988
RefSeqiNP_567530.4, NM_117855.6
UniGeneiAt.23185
At.68141

Genome annotation databases

EnsemblPlantsiAT4G17500.1; AT4G17500.1; AT4G17500
GeneIDi827464
GrameneiAT4G17500.1; AT4G17500.1; AT4G17500
KEGGiath:AT4G17500

Similar proteinsi

Entry informationi

Entry nameiEF100_ARATH
AccessioniPrimary (citable) accession number: O80337
Secondary accession number(s): Q93Z36, Q9SUK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 27, 2002
Last modified: April 25, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health