O80292 (LYS_BPPS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysozyme
EC=3.2.1.17

Alternative name(s):
Endolysin
Lysis protein
Muramidase
Protein gp19

Gene names

Name:

19

Organism

Bacteriophage PS119

Taxonomic identifier

83128 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Caudovirales › Podoviridae › unclassified Podoviridae

Virus host

Salmonella typhimurium [TaxID: 90371]

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity By similarity.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Sequence similarities	Belongs to the glycosyl hydrolase 24 family.

Ontologies

Keywords
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Lysozyme		PRO_0000218105
Sites
	Active site	37	1	Proton donor By similarity
	Active site	46	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	O80292 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: E1D72ACCA49E32FC	FASTA	167	18,232
	10 20 30 40 50 60 MAMSPALRNS VMAAISGGAI AIASVLITGP GGNDGLEGVR YKPYKDVVGV LTVCYGHTGK 70 80 90 100 110 120 DIMPGKTYTE AECKALLNKD LITVARQINP YIKVDIPETT RGALYSFVYN VGAGNFRTST 130 140 150 160 LLRKINQGDI KGACDQLRRW TYAGGKQWKG LMTRREVERD VCLWGKQ

References

[1]	"Lysis gene modules in the phage P22 gene pool." Zimmer A., Schmieger H. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ011581 Genomic DNA. Translation: CAA09710.1.
3D structure databases
ProteinModelPortal	O80292.
ModBase	Search...
Protein family/group databases
CAZy	GH24. Glycoside Hydrolase Family 24.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.530.40. 1 hit.
InterPro	IPR002196. Glyco_hydro_24. IPR023346. Lysozyme-like_dom. IPR023347. Lysozyme_dom. [Graphical view]
Pfam	PF00959. Phage_lysozyme. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LYS_BPPS1

Accession

Primary (citable) accession number: O80292

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1998
Last modified:	March 6, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program