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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-SSC-611105. Respiratory electron transport.
R-SSC-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei284 – 303HelicalSequence analysisAdd BLAST20
Transmembranei308 – 330HelicalSequence analysisAdd BLAST23
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Transmembranei391 – 413HelicalSequence analysisAdd BLAST23
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001179701 – 459NADH-ubiquinone oxidoreductase chain 4Add BLAST459

Proteomic databases

PaxDbiO79881.
PeptideAtlasiO79881.
PRIDEiO79881.

Expressioni

Gene expression databases

BgeeiENSSSCG00000018087.
GenevisibleiO79881. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000019144.

Structurei

3D structure databases

ProteinModelPortaliO79881.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4845. Eukaryota.
COG1008. LUCA.
GeneTreeiENSGT00730000111316.
HOVERGENiHBG093667.
InParanoidiO79881.
KOiK03881.
OMAiHAWIKDF.
OrthoDBiEOG091G0T7G.
TreeFamiTF343520.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O79881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIIIPTTM LLPMTWMSKH NMIWINATVH SLLISLISLS LLNQLGENSL
60 70 80 90 100
NFSLTFFSDS LSAPLLVLTT WLLPLMLMAS QSHLSKETTT RKKLYITMLI
110 120 130 140 150
LLQLFLIMTF TATELILFYI LFEATLVPTL IIITRWGNQT ERLNAGLYFL
160 170 180 190 200
FYTLAGSLPL LVALVYIQNT TGSLNFLIIH YWSHPLSNSW SNIFMWLACI
210 220 230 240 250
MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG YGMMRITTIL
260 270 280 290 300
NPLTNYMAYP FLMLSMWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA
310 320 330 340 350
IMIQTPWSFM GATALMIAHG LTSSMLFCLA NTNYERVHSR TMILARGLQT
360 370 380 390 400
LLPLMATWWL MASLTNLALP PSINLIGELF IITASFSWSN ITIILMGMNM
410 420 430 440 450
MITALYSLYM LITTQRGKYT HHINNIKASF TRENALMALH ILPLLLLTLN

PKMILGPLY
Length:459
Mass (Da):51,825
Last modified:May 2, 2002 - v2
Checksum:i7625EF89388E92AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti361M → V in CAA05237 (PubMed:9732457).Curated1
Sequence conflicti428A → P in CAA05237 (PubMed:9732457).Curated1
Sequence conflicti459Y → YC in CAA05237 (PubMed:9732457).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002189 Genomic DNA. Translation: CAA05237.1.
AF034253 Genomic DNA. Translation: AAD34194.1.
PIRiT10981.
RefSeqiNP_008643.1. NC_000845.1.

Genome annotation databases

EnsembliENSSSCT00000019682; ENSSSCP00000019144; ENSSSCG00000018087.
GeneIDi808510.
KEGGissc:808510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002189 Genomic DNA. Translation: CAA05237.1.
AF034253 Genomic DNA. Translation: AAD34194.1.
PIRiT10981.
RefSeqiNP_008643.1. NC_000845.1.

3D structure databases

ProteinModelPortaliO79881.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000019144.

Proteomic databases

PaxDbiO79881.
PeptideAtlasiO79881.
PRIDEiO79881.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000019682; ENSSSCP00000019144; ENSSSCG00000018087.
GeneIDi808510.
KEGGissc:808510.

Organism-specific databases

CTDi4538.

Phylogenomic databases

eggNOGiKOG4845. Eukaryota.
COG1008. LUCA.
GeneTreeiENSGT00730000111316.
HOVERGENiHBG093667.
InParanoidiO79881.
KOiK03881.
OMAiHAWIKDF.
OrthoDBiEOG091G0T7G.
TreeFamiTF343520.

Enzyme and pathway databases

ReactomeiR-SSC-611105. Respiratory electron transport.
R-SSC-6799198. Complex I biogenesis.

Gene expression databases

BgeeiENSSSCG00000018087.
GenevisibleiO79881. SS.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU4M_PIG
AccessioniPrimary (citable) accession number: O79881
Secondary accession number(s): Q9TDR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 2, 2002
Last modified: November 2, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.