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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiREACT_293041. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei98 – 11821HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence AnalysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Transmembranei284 – 30320HelicalSequence AnalysisAdd
BLAST
Transmembranei308 – 33023HelicalSequence AnalysisAdd
BLAST
Transmembranei351 – 37121HelicalSequence AnalysisAdd
BLAST
Transmembranei391 – 41323HelicalSequence AnalysisAdd
BLAST
Transmembranei435 – 45521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459NADH-ubiquinone oxidoreductase chain 4PRO_0000117970Add
BLAST

Expressioni

Gene expression databases

GenevisibleiO79881. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000019144.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1008.
GeneTreeiENSGT00730000111316.
HOVERGENiHBG093667.
InParanoidiO79881.
KOiK03881.
OMAiMWLACMM.
OrthoDBiEOG7DJSMN.
TreeFamiTF343520.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O79881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIIIPTTM LLPMTWMSKH NMIWINATVH SLLISLISLS LLNQLGENSL
60 70 80 90 100
NFSLTFFSDS LSAPLLVLTT WLLPLMLMAS QSHLSKETTT RKKLYITMLI
110 120 130 140 150
LLQLFLIMTF TATELILFYI LFEATLVPTL IIITRWGNQT ERLNAGLYFL
160 170 180 190 200
FYTLAGSLPL LVALVYIQNT TGSLNFLIIH YWSHPLSNSW SNIFMWLACI
210 220 230 240 250
MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG YGMMRITTIL
260 270 280 290 300
NPLTNYMAYP FLMLSMWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA
310 320 330 340 350
IMIQTPWSFM GATALMIAHG LTSSMLFCLA NTNYERVHSR TMILARGLQT
360 370 380 390 400
LLPLMATWWL MASLTNLALP PSINLIGELF IITASFSWSN ITIILMGMNM
410 420 430 440 450
MITALYSLYM LITTQRGKYT HHINNIKASF TRENALMALH ILPLLLLTLN

PKMILGPLY
Length:459
Mass (Da):51,825
Last modified:May 2, 2002 - v2
Checksum:i7625EF89388E92AF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti361 – 3611M → V in CAA05237 (PubMed:9732457).Curated
Sequence conflicti428 – 4281A → P in CAA05237 (PubMed:9732457).Curated
Sequence conflicti459 – 4591Y → YC in CAA05237 (PubMed:9732457).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002189 Genomic DNA. Translation: CAA05237.1.
AF034253 Genomic DNA. Translation: AAD34194.1.
PIRiT10981.
RefSeqiNP_008643.1. NC_000845.1.

Genome annotation databases

EnsembliENSSSCT00000019682; ENSSSCP00000019144; ENSSSCG00000018087.
GeneIDi808510.
KEGGissc:808510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002189 Genomic DNA. Translation: CAA05237.1.
AF034253 Genomic DNA. Translation: AAD34194.1.
PIRiT10981.
RefSeqiNP_008643.1. NC_000845.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000019144.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000019682; ENSSSCP00000019144; ENSSSCG00000018087.
GeneIDi808510.
KEGGissc:808510.

Organism-specific databases

CTDi4538.

Phylogenomic databases

eggNOGiCOG1008.
GeneTreeiENSGT00730000111316.
HOVERGENiHBG093667.
InParanoidiO79881.
KOiK03881.
OMAiMWLACMM.
OrthoDBiEOG7DJSMN.
TreeFamiTF343520.

Enzyme and pathway databases

ReactomeiREACT_293041. Respiratory electron transport.

Gene expression databases

GenevisibleiO79881. SS.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete mitochondrial DNA sequence of the pig (Sus scrofa)."
    Ursing B.M., Arnason U.
    J. Mol. Evol. 47:302-306(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete nucleotide sequence of pig (Sus scrofa) mitochondrial genome and dating evolutionary divergence within artiodactyla."
    Lin C.S., Sun Y.L., Liu C.Y., Yang P.C., Chang L.C., Cheng I.C., Mao S.J.T., Huang M.C.
    Gene 236:107-114(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Landrace.

Entry informationi

Entry nameiNU4M_PIG
AccessioniPrimary (citable) accession number: O79881
Secondary accession number(s): Q9TDR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 2, 2002
Last modified: July 22, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.