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O79881

- NU4M_PIG

UniProt

O79881 - NU4M_PIG

Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (02 May 2002)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
    Alternative name(s):
    NADH dehydrogenase subunit 4
    Gene namesi
    Name:MT-ND4
    Synonyms:MTND4, NADH4, ND4
    Encoded oniMitochondrion
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex I Source: Ensembl

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 459459NADH-ubiquinone oxidoreductase chain 4PRO_0000117970Add
    BLAST

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei284 – 30320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 33023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei351 – 37121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei391 – 41323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei435 – 45521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 4 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1008.
    GeneTreeiENSGT00730000111316.
    HOVERGENiHBG093667.
    KOiK03881.
    OrthoDBiEOG7DJSMN.
    TreeFamiTF343520.

    Family and domain databases

    InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    IPR000260. NADH_UbQ_OxRdtase_chain4_N.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    PF01059. Oxidored_q5_N. 1 hit.
    [Graphical view]
    PRINTSiPR01437. NUOXDRDTASE4.
    TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O79881-1 [UniParc]FASTAAdd to Basket

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    MLKIIIPTTM LLPMTWMSKH NMIWINATVH SLLISLISLS LLNQLGENSL    50
    NFSLTFFSDS LSAPLLVLTT WLLPLMLMAS QSHLSKETTT RKKLYITMLI 100
    LLQLFLIMTF TATELILFYI LFEATLVPTL IIITRWGNQT ERLNAGLYFL 150
    FYTLAGSLPL LVALVYIQNT TGSLNFLIIH YWSHPLSNSW SNIFMWLACI 200
    MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG YGMMRITTIL 250
    NPLTNYMAYP FLMLSMWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA 300
    IMIQTPWSFM GATALMIAHG LTSSMLFCLA NTNYERVHSR TMILARGLQT 350
    LLPLMATWWL MASLTNLALP PSINLIGELF IITASFSWSN ITIILMGMNM 400
    MITALYSLYM LITTQRGKYT HHINNIKASF TRENALMALH ILPLLLLTLN 450
    PKMILGPLY 459
    Length:459
    Mass (Da):51,825
    Last modified:May 2, 2002 - v2
    Checksum:i7625EF89388E92AF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti361 – 3611M → V in CAA05237. (PubMed:9732457)Curated
    Sequence conflicti428 – 4281A → P in CAA05237. (PubMed:9732457)Curated
    Sequence conflicti459 – 4591Y → YC in CAA05237. (PubMed:9732457)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ002189 Genomic DNA. Translation: CAA05237.1.
    AF034253 Genomic DNA. Translation: AAD34194.1.
    PIRiT10981.
    RefSeqiNP_008643.1. NC_000845.1.

    Genome annotation databases

    EnsembliENSSSCT00000019682; ENSSSCP00000019144; ENSSSCG00000018087.
    GeneIDi808510.
    KEGGissc:808510.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ002189 Genomic DNA. Translation: CAA05237.1 .
    AF034253 Genomic DNA. Translation: AAD34194.1 .
    PIRi T10981.
    RefSeqi NP_008643.1. NC_000845.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000019682 ; ENSSSCP00000019144 ; ENSSSCG00000018087 .
    GeneIDi 808510.
    KEGGi ssc:808510.

    Organism-specific databases

    CTDi 4538.

    Phylogenomic databases

    eggNOGi COG1008.
    GeneTreei ENSGT00730000111316.
    HOVERGENi HBG093667.
    KOi K03881.
    OrthoDBi EOG7DJSMN.
    TreeFami TF343520.

    Family and domain databases

    InterProi IPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    IPR000260. NADH_UbQ_OxRdtase_chain4_N.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    PF01059. Oxidored_q5_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01437. NUOXDRDTASE4.
    TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete mitochondrial DNA sequence of the pig (Sus scrofa)."
      Ursing B.M., Arnason U.
      J. Mol. Evol. 47:302-306(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete nucleotide sequence of pig (Sus scrofa) mitochondrial genome and dating evolutionary divergence within artiodactyla."
      Lin C.S., Sun Y.L., Liu C.Y., Yang P.C., Chang L.C., Cheng I.C., Mao S.J.T., Huang M.C.
      Gene 236:107-114(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Landrace.

    Entry informationi

    Entry nameiNU4M_PIG
    AccessioniPrimary (citable) accession number: O79881
    Secondary accession number(s): Q9TDR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 2, 2002
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3