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O79881 (NU4M_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded onMitochondrion
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459NADH-ubiquinone oxidoreductase chain 4
PRO_0000117970

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane98 – 11821Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane193 – 21321Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane257 – 27721Helical; Potential
Transmembrane284 – 30320Helical; Potential
Transmembrane308 – 33023Helical; Potential
Transmembrane351 – 37121Helical; Potential
Transmembrane391 – 41323Helical; Potential
Transmembrane435 – 45521Helical; Potential

Experimental info

Sequence conflict3611M → V in CAA05237. Ref.1
Sequence conflict4281A → P in CAA05237. Ref.1
Sequence conflict4591Y → YC in CAA05237. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O79881 [UniParc].

Last modified May 2, 2002. Version 2.
Checksum: 7625EF89388E92AF

FASTA45951,825
        10         20         30         40         50         60 
MLKIIIPTTM LLPMTWMSKH NMIWINATVH SLLISLISLS LLNQLGENSL NFSLTFFSDS 

        70         80         90        100        110        120 
LSAPLLVLTT WLLPLMLMAS QSHLSKETTT RKKLYITMLI LLQLFLIMTF TATELILFYI 

       130        140        150        160        170        180 
LFEATLVPTL IIITRWGNQT ERLNAGLYFL FYTLAGSLPL LVALVYIQNT TGSLNFLIIH 

       190        200        210        220        230        240 
YWSHPLSNSW SNIFMWLACI MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG 

       250        260        270        280        290        300 
YGMMRITTIL NPLTNYMAYP FLMLSMWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA 

       310        320        330        340        350        360 
IMIQTPWSFM GATALMIAHG LTSSMLFCLA NTNYERVHSR TMILARGLQT LLPLMATWWL 

       370        380        390        400        410        420 
MASLTNLALP PSINLIGELF IITASFSWSN ITIILMGMNM MITALYSLYM LITTQRGKYT 

       430        440        450 
HHINNIKASF TRENALMALH ILPLLLLTLN PKMILGPLY 

« Hide

References

« Hide 'large scale' references
[1]"The complete mitochondrial DNA sequence of the pig (Sus scrofa)."
Ursing B.M., Arnason U.
J. Mol. Evol. 47:302-306(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete nucleotide sequence of pig (Sus scrofa) mitochondrial genome and dating evolutionary divergence within artiodactyla."
Lin C.S., Sun Y.L., Liu C.Y., Yang P.C., Chang L.C., Cheng I.C., Mao S.J.T., Huang M.C.
Gene 236:107-114(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Landrace.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ002189 Genomic DNA. Translation: CAA05237.1.
AF034253 Genomic DNA. Translation: AAD34194.1.
PIRT10981.
RefSeqNP_008643.1. NC_000845.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000019682; ENSSSCP00000019144; ENSSSCG00000018087.
GeneID808510.
KEGGssc:808510.

Organism-specific databases

CTD4538.

Phylogenomic databases

eggNOGCOG1008.
GeneTreeENSGT00730000111316.
HOVERGENHBG093667.
KOK03881.
OrthoDBEOG7DJSMN.
TreeFamTF343520.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4M_PIG
AccessionPrimary (citable) accession number: O79881
Secondary accession number(s): Q9TDR2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 2, 2002
Last modified: May 14, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families