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O79876

- COX1_PIG

UniProt

O79876 - COX1_PIG

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Protein

Cytochrome c oxidase subunit 1

Gene
MT-CO1, COI, COXI, MTCO1
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Iron (heme A axial ligand) Inferred
Metal bindingi240 – 2401Copper B Inferred
Metal bindingi244 – 2441Copper B Inferred
Metal bindingi290 – 2901Copper B Inferred
Metal bindingi291 – 2911Copper B Inferred
Metal bindingi376 – 3761Iron (heme A3 axial ligand) Inferred
Metal bindingi378 – 3781Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Reviewed predictionAdd
BLAST
Transmembranei56 – 7621Helical; Reviewed predictionAdd
BLAST
Transmembranei102 – 12221Helical; Reviewed predictionAdd
BLAST
Transmembranei145 – 16521Helical; Reviewed predictionAdd
BLAST
Transmembranei183 – 20321Helical; Reviewed predictionAdd
BLAST
Transmembranei234 – 25421Helical; Reviewed predictionAdd
BLAST
Transmembranei268 – 28821Helical; Reviewed predictionAdd
BLAST
Transmembranei310 – 33021Helical; Reviewed predictionAdd
BLAST
Transmembranei338 – 35821Helical; Reviewed predictionAdd
BLAST
Transmembranei380 – 40021Helical; Reviewed predictionAdd
BLAST
Transmembranei412 – 43221Helical; Reviewed predictionAdd
BLAST
Transmembranei456 – 47621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Cytochrome c oxidase subunit 1PRO_0000183391Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliO79876.
SMRiO79876. Positions 1-514.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
HOVERGENiHBG003841.
KOiK02256.
OMAiGRHEIET.
OrthoDBiEOG7Q8CMW.
TreeFamiTF353096.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O79876-1 [UniParc]FASTAAdd to Basket

« Hide

MFVNRWLYST NHKDIGTLYL LFGAWAGMVG TALSLLIRAE LGQPGTLLGD    50
DQIYNVIVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM 100
SFWLLPPSFL LLLASSMVEA GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL 150
HLAGVSSILG AINFITTIIN MKPPAMSQYQ TPLFVWSVLI TAVLLLLSLP 200
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG 250
FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD 300
TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMLW ALGFIFLFTV 350
GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFVHWFPLF 400
SGYTLNQAWA KIHFVIMFVG VNMTFFPQHF LGLSGMPRRY SDYPDAYTAW 450
NTISSMGSFI SLTAVMLMIF IIWEAFASKR EVSAVELTST NLEWLHGCPP 500
PYHTFEEPTY INLK 514
Length:514
Mass (Da):56,958
Last modified:May 2, 2002 - v2
Checksum:i6B5008565248CF3A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 502GD → PH in CAA05231. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ002189 Genomic DNA. Translation: CAA05231.1.
AF034253 Genomic DNA. Translation: AAD34187.1.
AF304203 Genomic DNA. Translation: AAG28218.1.
AF304200 Genomic DNA. Translation: AAG28179.1.
PIRiT10974.
RefSeqiNP_008636.1. NC_000845.1.

Genome annotation databases

EnsembliENSSSCT00000019670; ENSSSCP00000019137; ENSSSCG00000018075.
GeneIDi808503.
KEGGissc:808503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ002189 Genomic DNA. Translation: CAA05231.1 .
AF034253 Genomic DNA. Translation: AAD34187.1 .
AF304203 Genomic DNA. Translation: AAG28218.1 .
AF304200 Genomic DNA. Translation: AAG28179.1 .
PIRi T10974.
RefSeqi NP_008636.1. NC_000845.1.

3D structure databases

ProteinModelPortali O79876.
SMRi O79876. Positions 1-514.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000019670 ; ENSSSCP00000019137 ; ENSSSCG00000018075 .
GeneIDi 808503.
KEGGi ssc:808503.

Organism-specific databases

CTDi 4512.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
HOVERGENi HBG003841.
KOi K02256.
OMAi GRHEIET.
OrthoDBi EOG7Q8CMW.
TreeFami TF353096.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete mitochondrial DNA sequence of the pig (Sus scrofa)."
    Ursing B.M., Arnason U.
    J. Mol. Evol. 47:302-306(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete nucleotide sequence of pig (Sus scrofa) mitochondrial genome and dating evolutionary divergence within artiodactyla."
    Lin C.S., Sun Y.L., Liu C.Y., Yang P.C., Chang L.C., Cheng I.C., Mao S.J.T., Huang M.C.
    Gene 236:107-114(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Landrace.
  3. "A phylogenetic study of the origin of the domestic pig estimated from the near-complete mtDNA genome."
    Kijas J.M.H., Andersson L.
    J. Mol. Evol. 52:302-308(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Meishan and Swedish wild boar.

Entry informationi

Entry nameiCOX1_PIG
AccessioniPrimary (citable) accession number: O79876
Secondary accession number(s): Q9TDR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 2, 2002
Last modified: September 3, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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