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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Pelomedusa subrufa (African side-necked turtle)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiPelomedusa subrufa (African side-necked turtle)
Taxonomic identifieri44522 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaTestudinesPleurodiraPelomedusidaePelomedusa

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei94 – 113HelicalSequence analysisAdd BLAST20
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei285 – 304HelicalSequence analysisAdd BLAST20
Transmembranei308 – 330HelicalSequence analysisAdd BLAST23
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001179661 – 459NADH-ubiquinone oxidoreductase chain 4Add BLAST459

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O79677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLLLPMIM LLPTSWLCKK NHLSYTTLLF SFTIALLSLQ WLKPPFELTT
60 70 80 90 100
TFSNTYMGVD PISTPLLILT SWMTPLMILV SKNHLIQEPL SRKRTFTTTI
110 120 130 140 150
ISLQISLTLA FSALEMMLFF TMFEATLIPT LIIITRWGNQ MERLSAGTYF
160 170 180 190 200
LFYTLIGSLP LLIALTSLHT NYNTLSLFIL QLNPPNLTNS WAHTMWWFAL
210 220 230 240 250
LMAFMIKMPL YGLHLWLPKA HVEAPIAGSM ILAGVLLKLG GYGIIRVTLM
260 270 280 290 300
LNPLTKSLSY PFMTLSLWGI IMTGLICLRQ TDLKSLIAYS SVGLMGLVIS
310 320 330 340 350
AALLQTPLSI TGAIILMIAH GLSSSMLFCL ANTNYERTHN RTLLLTHSMQ
360 370 380 390 400
TLLPLMTIWW LLASLMNMAL PPTINLMGEL TIIASLFSWA NITIILTGLG
410 420 430 440 450
TLISALYSLH MFSTTQWGGT PPHHMHTITP SHTREHLIMM LHMVPLILLM

MKPQLMTTF
Length:459
Mass (Da):51,629
Last modified:November 1, 1998 - v1
Checksum:i89BC451BD09482CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039066 Genomic DNA. Translation: AAD05057.1.
PIRiT11110.
RefSeqiNP_008441.1. NC_001947.1.

Genome annotation databases

GeneIDi808289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039066 Genomic DNA. Translation: AAD05057.1.
PIRiT11110.
RefSeqiNP_008441.1. NC_001947.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808289.

Organism-specific databases

CTDi4538.

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU4M_PELSU
AccessioniPrimary (citable) accession number: O79677
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: September 16, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.