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O79677 (NU4M_PELSU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded onMitochondrion
OrganismPelomedusa subrufa (African side-necked turtle)
Taxonomic identifier44522 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupTestudinesPleurodiraPelomedusidaePelomedusa

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459NADH-ubiquinone oxidoreductase chain 4
PRO_0000117966

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane61 – 8121Helical; Potential
Transmembrane94 – 11320Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane146 – 16621Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane285 – 30420Helical; Potential
Transmembrane308 – 33023Helical; Potential
Transmembrane352 – 37221Helical; Potential
Transmembrane380 – 40021Helical; Potential
Transmembrane437 – 45721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O79677 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 89BC451BD09482CC

FASTA45951,629
        10         20         30         40         50         60 
MLKLLLPMIM LLPTSWLCKK NHLSYTTLLF SFTIALLSLQ WLKPPFELTT TFSNTYMGVD 

        70         80         90        100        110        120 
PISTPLLILT SWMTPLMILV SKNHLIQEPL SRKRTFTTTI ISLQISLTLA FSALEMMLFF 

       130        140        150        160        170        180 
TMFEATLIPT LIIITRWGNQ MERLSAGTYF LFYTLIGSLP LLIALTSLHT NYNTLSLFIL 

       190        200        210        220        230        240 
QLNPPNLTNS WAHTMWWFAL LMAFMIKMPL YGLHLWLPKA HVEAPIAGSM ILAGVLLKLG 

       250        260        270        280        290        300 
GYGIIRVTLM LNPLTKSLSY PFMTLSLWGI IMTGLICLRQ TDLKSLIAYS SVGLMGLVIS 

       310        320        330        340        350        360 
AALLQTPLSI TGAIILMIAH GLSSSMLFCL ANTNYERTHN RTLLLTHSMQ TLLPLMTIWW 

       370        380        390        400        410        420 
LLASLMNMAL PPTINLMGEL TIIASLFSWA NITIILTGLG TLISALYSLH MFSTTQWGGT 

       430        440        450 
PPHHMHTITP SHTREHLIMM LHMVPLILLM MKPQLMTTF 

« Hide

References

[1]"Complete mitochondrial genome suggests diapsid affinities of turtles."
Zardoya R., Meyer A.
Proc. Natl. Acad. Sci. U.S.A. 95:14226-14231(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF039066 Genomic DNA. Translation: AAD05057.1.
PIRT11110.
RefSeqNP_008441.1. NC_001947.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808289.

Organism-specific databases

CTD4538.

Phylogenomic databases

HOVERGENHBG093667.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4M_PELSU
AccessionPrimary (citable) accession number: O79677
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families