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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

MT-ND5

Organism
Lycodon semicarinatus (Ryukyu odd-tooth snake) (Eumesodon semicarinatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:MT-ND5
Synonyms:MTND5, NADH5, ND5
Encoded oniMitochondrion
OrganismiLycodon semicarinatus (Ryukyu odd-tooth snake) (Eumesodon semicarinatus)
Taxonomic identifieri56549 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaColubridaeColubrinaeLycodon

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Transmembranei314 – 336HelicalSequence analysisAdd BLAST23
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Transmembranei439 – 461HelicalSequence analysisAdd BLAST23
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Transmembranei568 – 588HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001180891 – 590NADH-ubiquinone oxidoreductase chain 5Add BLAST590

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O79556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLITPTIIL TIMLSLMMSI MQPHNNTKNN LMVLFLISLI PINPLLNNNE
60 70 80 90 100
LTLTLTPLII SPTENINISI TLDTASLLFT PIALFITWSI TEFSLWYMAT
110 120 130 140 150
DPNINKFIKY LLTFLITMLV IITANNMYQL FIGWEGVGIM SFLLIGWWHG
160 170 180 190 200
RQDANTAALQ AIIYNRIGDI GLIMTTAWMM TTSSINMQEL MIQHEVVNII
210 220 230 240 250
PLLGLVAAAT GKSAQFSLHP WLPSAMEGPT PVSALLHSST MVVAGVFLLI
260 270 280 290 300
RLHPILHNNK IMLTCCLILG ATTTMFAAAA ATTYFDIKKI IALSTTSQLG
310 320 330 340 350
LMMTMIGLNQ PTLAFLHMIT HSFFKAMLFL CSGSYIHNLN NEQDIRMMGG
360 370 380 390 400
LLKTLPMTSS FLTIANLSLM GMPFLSGFYS KDTIIETLAN SYTNSWAIMI
410 420 430 440 450
TMIATILSAC YSTQIMLFTI MEHPRTHHTT HKETKNITHP LARLMLTSIL
460 470 480 490 500
MGTMTKMSTL QTTTMVTMPK TIKLMALIST IIGVLLSKDL THMTHHMKPK
510 520 530 540 550
KPNKQNMFFN QLAFFNIPHR TITINTLKIS QQTSTELMDL WTLEVWGPKG
560 570 580 590
LSNTITNTIH LLTQQKNMIK NYMAIFTMTT MTVLLFIMSK
Length:590
Mass (Da):66,179
Last modified:November 1, 1998 - v1
Checksum:iB24E0BD829B28DCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008539 Genomic DNA. Translation: BAA33032.1.
PIRiT11098.
RefSeqiNP_008429.1. NC_001945.1.

Genome annotation databases

GeneIDi808266.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008539 Genomic DNA. Translation: BAA33032.1.
PIRiT11098.
RefSeqiNP_008429.1. NC_001945.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808266.

Organism-specific databases

CTDi4540.

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNU5M_LYCSM
AccessioniPrimary (citable) accession number: O79556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: September 16, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.