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O79555

- NU4M_LYCSM

UniProt

O79555 - NU4M_LYCSM

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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Lycodon semicarinatus (Ryukyu odd-tooth snake) (Eumesodon semicarinatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiLycodon semicarinatus (Ryukyu odd-tooth snake) (Eumesodon semicarinatus)
Taxonomic identifieri56549 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaColubridaeColubrinaeLycodon

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445NADH-ubiquinone oxidoreductase chain 4PRO_0000117929Add
BLAST

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence AnalysisAdd
BLAST
Transmembranei186 – 20621HelicalSequence AnalysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence AnalysisAdd
BLAST
Transmembranei248 – 26821HelicalSequence AnalysisAdd
BLAST
Transmembranei276 – 29621HelicalSequence AnalysisAdd
BLAST
Transmembranei300 – 32021HelicalSequence AnalysisAdd
BLAST
Transmembranei332 – 35221HelicalSequence AnalysisAdd
BLAST
Transmembranei383 – 40321HelicalSequence AnalysisAdd
BLAST
Transmembranei425 – 44521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O79555-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKITFMTMM LIPTTLILKP KMLYQTTTSY SFMIALFSLS LLEPNSNTYL
60 70 80 90 100
HLDSTSAPLL LLSYWLMPMT MMASQHAMNK EPLQRQRTFL SILTLLQLFI
110 120 130 140 150
SLTFMASNIT LMYIMFEATL IPTLIIITRW GQQTERLTAG TYFMMYTLTT
160 170 180 190 200
SMPLLTAILF INNTTNTPTL FMQMMQTTSP WTELMLWIAC LGAFLAKMPV
210 220 230 240 250
YGLHLWLPKA HVEAPIAGSM VLAAILLKLG GYGIIRMTQI LPTMKTDLFL
260 270 280 290 300
PFIVLSLWGA TLANLTCLQQ TDLKSLIAYS SVSHMGLVIA ATMIQTQWSL
310 320 330 340 350
SGAMALMIAH GFTSSALFCL ANTTYERTKT RIMILTRGFH SILPMITTWW
360 370 380 390 400
LMTNLMNIAT PPSINFTGEL LIASSLFNWC PTTIILFGLS MLITASYSLH
410 420 430 440
MLLSTQTGTP TLNMVTYPTH SREHLLMVLH ILPLMLISLK PELII
Length:445
Mass (Da):50,068
Last modified:November 1, 1998 - v1
Checksum:i97D37ED440D5DE62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB008539 Genomic DNA. Translation: BAA33031.1.
PIRiT11097.
RefSeqiNP_008428.1. NC_001945.1.

Genome annotation databases

GeneIDi808275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB008539 Genomic DNA. Translation: BAA33031.1 .
PIRi T11097.
RefSeqi NP_008428.1. NC_001945.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808275.

Organism-specific databases

CTDi 4538.

Phylogenomic databases

HOVERGENi HBG093667.

Family and domain databases

InterProi IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view ]
PRINTSi PR01437. NUOXDRDTASE4.
TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence of a snake (Dinodon semicarinatus) mitochondrial genome with two identical control regions."
    Kumazawa Y., Ota H., Nishida M., Ozawa T.
    Genetics 150:313-329(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.

Entry informationi

Entry nameiNU4M_LYCSM
AccessioniPrimary (citable) accession number: O79555
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3