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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Lycodon semicarinatus (Ryukyu odd-tooth snake) (Eumesodon semicarinatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiLycodon semicarinatus (Ryukyu odd-tooth snake) (Eumesodon semicarinatus)
Taxonomic identifieri56549 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaColubridaeColubrinaeLycodon

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Transmembranei332 – 352HelicalSequence analysisAdd BLAST21
Transmembranei383 – 403HelicalSequence analysisAdd BLAST21
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001179291 – 445NADH-ubiquinone oxidoreductase chain 4Add BLAST445

Structurei

3D structure databases

ProteinModelPortaliO79555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O79555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKITFMTMM LIPTTLILKP KMLYQTTTSY SFMIALFSLS LLEPNSNTYL
60 70 80 90 100
HLDSTSAPLL LLSYWLMPMT MMASQHAMNK EPLQRQRTFL SILTLLQLFI
110 120 130 140 150
SLTFMASNIT LMYIMFEATL IPTLIIITRW GQQTERLTAG TYFMMYTLTT
160 170 180 190 200
SMPLLTAILF INNTTNTPTL FMQMMQTTSP WTELMLWIAC LGAFLAKMPV
210 220 230 240 250
YGLHLWLPKA HVEAPIAGSM VLAAILLKLG GYGIIRMTQI LPTMKTDLFL
260 270 280 290 300
PFIVLSLWGA TLANLTCLQQ TDLKSLIAYS SVSHMGLVIA ATMIQTQWSL
310 320 330 340 350
SGAMALMIAH GFTSSALFCL ANTTYERTKT RIMILTRGFH SILPMITTWW
360 370 380 390 400
LMTNLMNIAT PPSINFTGEL LIASSLFNWC PTTIILFGLS MLITASYSLH
410 420 430 440
MLLSTQTGTP TLNMVTYPTH SREHLLMVLH ILPLMLISLK PELII
Length:445
Mass (Da):50,068
Last modified:November 1, 1998 - v1
Checksum:i97D37ED440D5DE62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008539 Genomic DNA. Translation: BAA33031.1.
PIRiT11097.
RefSeqiNP_008428.1. NC_001945.1.

Genome annotation databases

GeneIDi808275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008539 Genomic DNA. Translation: BAA33031.1.
PIRiT11097.
RefSeqiNP_008428.1. NC_001945.1.

3D structure databases

ProteinModelPortaliO79555.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808275.

Organism-specific databases

CTDi4538.

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU4M_LYCSM
AccessioniPrimary (citable) accession number: O79555
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.