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O79555 (NU4M_DINSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded onMitochondrion
OrganismDinodon semicarinatum (Ryukyu odd-tooth snake) (Eumesodon semicarinatus)
Taxonomic identifier56549 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaColubridaeColubrinaeDinodon

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445NADH-ubiquinone oxidoreductase chain 4
PRO_0000117929

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane54 – 7421Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane141 – 16121Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane215 – 23521Helical; Potential
Transmembrane248 – 26821Helical; Potential
Transmembrane276 – 29621Helical; Potential
Transmembrane300 – 32021Helical; Potential
Transmembrane332 – 35221Helical; Potential
Transmembrane383 – 40321Helical; Potential
Transmembrane425 – 44521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O79555 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 97D37ED440D5DE62

FASTA44550,068
        10         20         30         40         50         60 
MLKITFMTMM LIPTTLILKP KMLYQTTTSY SFMIALFSLS LLEPNSNTYL HLDSTSAPLL 

        70         80         90        100        110        120 
LLSYWLMPMT MMASQHAMNK EPLQRQRTFL SILTLLQLFI SLTFMASNIT LMYIMFEATL 

       130        140        150        160        170        180 
IPTLIIITRW GQQTERLTAG TYFMMYTLTT SMPLLTAILF INNTTNTPTL FMQMMQTTSP 

       190        200        210        220        230        240 
WTELMLWIAC LGAFLAKMPV YGLHLWLPKA HVEAPIAGSM VLAAILLKLG GYGIIRMTQI 

       250        260        270        280        290        300 
LPTMKTDLFL PFIVLSLWGA TLANLTCLQQ TDLKSLIAYS SVSHMGLVIA ATMIQTQWSL 

       310        320        330        340        350        360 
SGAMALMIAH GFTSSALFCL ANTTYERTKT RIMILTRGFH SILPMITTWW LMTNLMNIAT 

       370        380        390        400        410        420 
PPSINFTGEL LIASSLFNWC PTTIILFGLS MLITASYSLH MLLSTQTGTP TLNMVTYPTH 

       430        440 
SREHLLMVLH ILPLMLISLK PELII 

« Hide

References

[1]"The complete nucleotide sequence of a snake (Dinodon semicarinatus) mitochondrial genome with two identical control regions."
Kumazawa Y., Ota H., Nishida M., Ozawa T.
Genetics 150:313-329(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB008539 Genomic DNA. Translation: BAA33031.1.
PIRT11097.
RefSeqNP_008428.1. NC_001945.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808275.

Organism-specific databases

CTD4538.

Phylogenomic databases

HOVERGENHBG093667.
ProtClustDBMTH00124.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4M_DINSE
AccessionPrimary (citable) accession number: O79555
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families