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O79555

- NU4M_DINSE

UniProt

O79555 - NU4M_DINSE

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Protein
NADH-ubiquinone oxidoreductase chain 4
Gene
MT-ND4, MTND4, NADH4, ND4
Organism
Dinodon semicarinatum (Ryukyu odd-tooth snake) (Eumesodon semicarinatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiDinodon semicarinatum (Ryukyu odd-tooth snake) (Eumesodon semicarinatus)
Taxonomic identifieri56549 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaColubridaeColubrinaeDinodon

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221Helical; Reviewed prediction
Add
BLAST
Transmembranei54 – 7421Helical; Reviewed prediction
Add
BLAST
Transmembranei87 – 10721Helical; Reviewed prediction
Add
BLAST
Transmembranei108 – 12821Helical; Reviewed prediction
Add
BLAST
Transmembranei141 – 16121Helical; Reviewed prediction
Add
BLAST
Transmembranei186 – 20621Helical; Reviewed prediction
Add
BLAST
Transmembranei215 – 23521Helical; Reviewed prediction
Add
BLAST
Transmembranei248 – 26821Helical; Reviewed prediction
Add
BLAST
Transmembranei276 – 29621Helical; Reviewed prediction
Add
BLAST
Transmembranei300 – 32021Helical; Reviewed prediction
Add
BLAST
Transmembranei332 – 35221Helical; Reviewed prediction
Add
BLAST
Transmembranei383 – 40321Helical; Reviewed prediction
Add
BLAST
Transmembranei425 – 44521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445NADH-ubiquinone oxidoreductase chain 4
PRO_0000117929Add
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O79555-1 [UniParc]FASTAAdd to Basket

« Hide

MLKITFMTMM LIPTTLILKP KMLYQTTTSY SFMIALFSLS LLEPNSNTYL    50
HLDSTSAPLL LLSYWLMPMT MMASQHAMNK EPLQRQRTFL SILTLLQLFI 100
SLTFMASNIT LMYIMFEATL IPTLIIITRW GQQTERLTAG TYFMMYTLTT 150
SMPLLTAILF INNTTNTPTL FMQMMQTTSP WTELMLWIAC LGAFLAKMPV 200
YGLHLWLPKA HVEAPIAGSM VLAAILLKLG GYGIIRMTQI LPTMKTDLFL 250
PFIVLSLWGA TLANLTCLQQ TDLKSLIAYS SVSHMGLVIA ATMIQTQWSL 300
SGAMALMIAH GFTSSALFCL ANTTYERTKT RIMILTRGFH SILPMITTWW 350
LMTNLMNIAT PPSINFTGEL LIASSLFNWC PTTIILFGLS MLITASYSLH 400
MLLSTQTGTP TLNMVTYPTH SREHLLMVLH ILPLMLISLK PELII 445
Length:445
Mass (Da):50,068
Last modified:November 1, 1998 - v1
Checksum:i97D37ED440D5DE62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB008539 Genomic DNA. Translation: BAA33031.1.
PIRiT11097.
RefSeqiNP_008428.1. NC_001945.1.

Genome annotation databases

GeneIDi808275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB008539 Genomic DNA. Translation: BAA33031.1 .
PIRi T11097.
RefSeqi NP_008428.1. NC_001945.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808275.

Organism-specific databases

CTDi 4538.

Phylogenomic databases

HOVERGENi HBG093667.

Family and domain databases

InterProi IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view ]
PRINTSi PR01437. NUOXDRDTASE4.
TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence of a snake (Dinodon semicarinatus) mitochondrial genome with two identical control regions."
    Kumazawa Y., Ota H., Nishida M., Ozawa T.
    Genetics 150:313-329(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.

Entry informationi

Entry nameiNU4M_DINSE
AccessioniPrimary (citable) accession number: O79555
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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