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O79436 (NU4M_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded onMitochondrion
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459NADH-ubiquinone oxidoreductase chain 4
PRO_0000117980

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane257 – 27721Helical; Potential
Transmembrane284 – 30320Helical; Potential
Transmembrane308 – 33023Helical; Potential
Transmembrane351 – 37121Helical; Potential
Transmembrane375 – 39521Helical; Potential
Transmembrane439 – 45921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O79436 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 11B5ACA972DD97E6

FASTA45951,599
        10         20         30         40         50         60 
MLKTIIPTIM LIPTVWWSKP HMIWINATVY SLLISLTTLS LLNQPSDTNL NFSTTFFSDA 

        70         80         90        100        110        120 
LSTPLLMLTT WLLPLMILAS QHHLDKETLT RKKIYISLLI SLQVFLVMTF SATEFILFYI 

       130        140        150        160        170        180 
LFEATLIPTL IIITRWGNQT ERLNAGTYFL FYTLMGSLPL LVALIYLQNS MGSLNFLLLQ 

       190        200        210        220        230        240 
LMNKSITTSW SNSLMWLACM MAFLVKMPLY GLHLWLPKAH VEAPIAGSMV LAAILLKLGG 

       250        260        270        280        290        300 
YGMMRITILL SPITDYMAYP FLMLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA 

       310        320        330        340        350        360 
ILIQTPWSFM GATALMIAHG LTSSLLFCLA NSNYERIHSR TMLLARGLQT ILPLMAAWWL 

       370        380        390        400        410        420 
VASLTNLALP PTINLLGELL IIMASFSWSN LTIILMGTNV LITALYSLYM LSTTQRGKFT 

       430        440        450 
YHTNNISPTF TRENTLMVLH LAPLLLLSIS PKIILGLMF 

« Hide

References

[1]"The complete mitochondrial DNA sequence of the rabbit, Oryctolagus cuniculus."
Gissi C., Gullberg A., Arnason U.
Genomics 50:161-169(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ001588 Genomic DNA. Translation: CAA04856.1.
PIRT11489.
RefSeqNP_007558.1. NC_001913.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSOCUT00000033133; ENSOCUP00000026188; ENSOCUG00000029108.
GeneID808225.

Organism-specific databases

CTD4538.

Phylogenomic databases

GeneTreeENSGT00730000111316.
HOVERGENHBG093667.
OMAPNMIWIN.
OrthoDBEOG7DJSMN.
ProtClustDBMTH00110.
TreeFamTF343520.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4M_RABIT
AccessionPrimary (citable) accession number: O79436
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families