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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence AnalysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Transmembranei284 – 30320HelicalSequence AnalysisAdd
BLAST
Transmembranei308 – 33023HelicalSequence AnalysisAdd
BLAST
Transmembranei351 – 37121HelicalSequence AnalysisAdd
BLAST
Transmembranei375 – 39521HelicalSequence AnalysisAdd
BLAST
Transmembranei439 – 45921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459NADH-ubiquinone oxidoreductase chain 4PRO_0000117980Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000026188.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000111316.
HOVERGENiHBG093667.
InParanoidiO79436.
KOiK03881.
OMAiMWLACMM.
OrthoDBiEOG7DJSMN.
TreeFamiTF343520.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O79436-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKTIIPTIM LIPTVWWSKP HMIWINATVY SLLISLTTLS LLNQPSDTNL
60 70 80 90 100
NFSTTFFSDA LSTPLLMLTT WLLPLMILAS QHHLDKETLT RKKIYISLLI
110 120 130 140 150
SLQVFLVMTF SATEFILFYI LFEATLIPTL IIITRWGNQT ERLNAGTYFL
160 170 180 190 200
FYTLMGSLPL LVALIYLQNS MGSLNFLLLQ LMNKSITTSW SNSLMWLACM
210 220 230 240 250
MAFLVKMPLY GLHLWLPKAH VEAPIAGSMV LAAILLKLGG YGMMRITILL
260 270 280 290 300
SPITDYMAYP FLMLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA
310 320 330 340 350
ILIQTPWSFM GATALMIAHG LTSSLLFCLA NSNYERIHSR TMLLARGLQT
360 370 380 390 400
ILPLMAAWWL VASLTNLALP PTINLLGELL IIMASFSWSN LTIILMGTNV
410 420 430 440 450
LITALYSLYM LSTTQRGKFT YHTNNISPTF TRENTLMVLH LAPLLLLSIS

PKIILGLMF
Length:459
Mass (Da):51,599
Last modified:November 1, 1998 - v1
Checksum:i11B5ACA972DD97E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001588 Genomic DNA. Translation: CAA04856.1.
PIRiT11489.
RefSeqiNP_007558.1. NC_001913.1.

Genome annotation databases

EnsembliENSOCUT00000033133; ENSOCUP00000026188; ENSOCUG00000029108.
GeneIDi808225.
KEGGiocu:808225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001588 Genomic DNA. Translation: CAA04856.1.
PIRiT11489.
RefSeqiNP_007558.1. NC_001913.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000026188.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000033133; ENSOCUP00000026188; ENSOCUG00000029108.
GeneIDi808225.
KEGGiocu:808225.

Organism-specific databases

CTDi4538.

Phylogenomic databases

GeneTreeiENSGT00730000111316.
HOVERGENiHBG093667.
InParanoidiO79436.
KOiK03881.
OMAiMWLACMM.
OrthoDBiEOG7DJSMN.
TreeFamiTF343520.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete mitochondrial DNA sequence of the rabbit, Oryctolagus cuniculus."
    Gissi C., Gullberg A., Arnason U.
    Genomics 50:161-169(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ThorbeckeImported.

Entry informationi

Entry nameiNU4M_RABIT
AccessioniPrimary (citable) accession number: O79436
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: July 22, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.