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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei284 – 303HelicalSequence analysisAdd BLAST20
Transmembranei308 – 330HelicalSequence analysisAdd BLAST23
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001179801 – 459NADH-ubiquinone oxidoreductase chain 4Add BLAST459

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000026188.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4845. Eukaryota.
COG1008. LUCA.
GeneTreeiENSGT00730000111316.
HOVERGENiHBG093667.
InParanoidiO79436.
KOiK03881.
OMAiTAPVHML.
OrthoDBiEOG091G0T7G.
TreeFamiTF343520.

Family and domain databases

InterProiView protein in InterPro
IPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
PANTHERiPTHR43507. PTHR43507. 1 hit.
PfamiView protein in Pfam
PF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O79436-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKTIIPTIM LIPTVWWSKP HMIWINATVY SLLISLTTLS LLNQPSDTNL
60 70 80 90 100
NFSTTFFSDA LSTPLLMLTT WLLPLMILAS QHHLDKETLT RKKIYISLLI
110 120 130 140 150
SLQVFLVMTF SATEFILFYI LFEATLIPTL IIITRWGNQT ERLNAGTYFL
160 170 180 190 200
FYTLMGSLPL LVALIYLQNS MGSLNFLLLQ LMNKSITTSW SNSLMWLACM
210 220 230 240 250
MAFLVKMPLY GLHLWLPKAH VEAPIAGSMV LAAILLKLGG YGMMRITILL
260 270 280 290 300
SPITDYMAYP FLMLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA
310 320 330 340 350
ILIQTPWSFM GATALMIAHG LTSSLLFCLA NSNYERIHSR TMLLARGLQT
360 370 380 390 400
ILPLMAAWWL VASLTNLALP PTINLLGELL IIMASFSWSN LTIILMGTNV
410 420 430 440 450
LITALYSLYM LSTTQRGKFT YHTNNISPTF TRENTLMVLH LAPLLLLSIS

PKIILGLMF
Length:459
Mass (Da):51,599
Last modified:November 1, 1998 - v1
Checksum:i11B5ACA972DD97E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001588 Genomic DNA. Translation: CAA04856.1.
PIRiT11489.
RefSeqiNP_007558.1. NC_001913.1.

Genome annotation databases

EnsembliENSOCUT00000033133; ENSOCUP00000026188; ENSOCUG00000029108.
GeneIDi808225.
KEGGiocu:808225.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNU4M_RABIT
AccessioniPrimary (citable) accession number: O79436
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: June 7, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families