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O79421 (NU4M_BRALA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:ND4
Synonyms:NAD4, NADH4
Encoded onMitochondrion
OrganismBranchiostoma lanceolatum (Common lancelet) (Amphioxus)
Taxonomic identifier7740 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452NADH-ubiquinone oxidoreductase chain 4
PRO_0000117909

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane29 – 4921Helical; Potential
Transmembrane59 – 7921Helical; Potential
Transmembrane88 – 11023Helical; Potential
Transmembrane114 – 13623Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane182 – 20221Helical; Potential
Transmembrane221 – 24121Helical; Potential
Transmembrane252 – 27221Helical; Potential
Transmembrane282 – 30423Helical; Potential
Transmembrane309 – 33123Helical; Potential
Transmembrane345 – 36521Helical; Potential
Transmembrane390 – 41021Helical; Potential
Transmembrane432 – 45221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O79421 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 4067DB59EC184C7A

FASTA45249,940
        10         20         30         40         50         60 
MNHLVLGYVG LVIGVIVTKK SMVWRVGQVG SVLLMLPATV LVNMNMTISN VSYMMTSDFV 

        70         80         90        100        110        120 
SLGLTVLSIW LLPLMLLASQ QHMVSESLIY QRVFVGCQVF LTGALVLAFM ASDLLLFYIA 

       130        140        150        160        170        180 
FESTLLPTLM LITRWGAQKE RYQAGTYFMF FTLVGSLPLL ICLIGQYQMV GSLALDLSYE 

       190        200        210        220        230        240 
GVFQLSYLVN FWWVGCILAF LVKLPLYGVH LWLPKAHVEA PIAGSMVLAG VLLKLGGYGM 

       250        260        270        280        290        300 
MRVSLMWGAT AMLSSEVFLA LALWGIVVMG GICLRQTDLK SLIAYSSVGH MALVVGGVLT 

       310        320        330        340        350        360 
GVAWGYNGAM VLMIAHGLVS SCLFCLANLW YERSSTRNLS GSRGLIMIFP LISLGWFLMS 

       370        380        390        400        410        420 
LMNMALPPAI NLFGELVAMV ALYNWSPYSI VYMSLGAVLT AAYSLYLFGM SQWGNTMKNY 

       430        440        450 
KNLYTITSRE YLLTTLHLVP AIYLIFYLGL MF 

« Hide

References

[1]"Complete sequence of the amphioxus (Branchiostoma lanceolatum) mitochondrial genome: relations to vertebrates."
Spruyt N., Delarbre C., Gachelin G., Laudet V.
Nucleic Acids Res. 26:3279-3285(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y16474 Genomic DNA. Translation: CAA76256.1.
PIRC71391.
RefSeqNP_007546.1. NC_001912.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808213.

Organism-specific databases

CTD4538.

Phylogenomic databases

HOVERGENHBG093667.
ProtClustDBMTH00206.

Family and domain databases

InterProIPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
ProtoNetSearch...

Entry information

Entry nameNU4M_BRALA
AccessionPrimary (citable) accession number: O79421
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families