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O79421

- NU4M_BRALA

UniProt

O79421 - NU4M_BRALA

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Protein
NADH-ubiquinone oxidoreductase chain 4
Gene
ND4, NAD4, NADH4
Organism
Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:ND4
Synonyms:NAD4, NADH4
Encoded oniMitochondrion
OrganismiBranchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Taxonomic identifieri7740 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421Helical; Reviewed prediction
Add
BLAST
Transmembranei29 – 4921Helical; Reviewed prediction
Add
BLAST
Transmembranei59 – 7921Helical; Reviewed prediction
Add
BLAST
Transmembranei88 – 11023Helical; Reviewed prediction
Add
BLAST
Transmembranei114 – 13623Helical; Reviewed prediction
Add
BLAST
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST
Transmembranei182 – 20221Helical; Reviewed prediction
Add
BLAST
Transmembranei221 – 24121Helical; Reviewed prediction
Add
BLAST
Transmembranei252 – 27221Helical; Reviewed prediction
Add
BLAST
Transmembranei282 – 30423Helical; Reviewed prediction
Add
BLAST
Transmembranei309 – 33123Helical; Reviewed prediction
Add
BLAST
Transmembranei345 – 36521Helical; Reviewed prediction
Add
BLAST
Transmembranei390 – 41021Helical; Reviewed prediction
Add
BLAST
Transmembranei432 – 45221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452NADH-ubiquinone oxidoreductase chain 4
PRO_0000117909Add
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.

Sequencei

Sequence statusi: Complete.

O79421-1 [UniParc]FASTAAdd to Basket

« Hide

MNHLVLGYVG LVIGVIVTKK SMVWRVGQVG SVLLMLPATV LVNMNMTISN    50
VSYMMTSDFV SLGLTVLSIW LLPLMLLASQ QHMVSESLIY QRVFVGCQVF 100
LTGALVLAFM ASDLLLFYIA FESTLLPTLM LITRWGAQKE RYQAGTYFMF 150
FTLVGSLPLL ICLIGQYQMV GSLALDLSYE GVFQLSYLVN FWWVGCILAF 200
LVKLPLYGVH LWLPKAHVEA PIAGSMVLAG VLLKLGGYGM MRVSLMWGAT 250
AMLSSEVFLA LALWGIVVMG GICLRQTDLK SLIAYSSVGH MALVVGGVLT 300
GVAWGYNGAM VLMIAHGLVS SCLFCLANLW YERSSTRNLS GSRGLIMIFP 350
LISLGWFLMS LMNMALPPAI NLFGELVAMV ALYNWSPYSI VYMSLGAVLT 400
AAYSLYLFGM SQWGNTMKNY KNLYTITSRE YLLTTLHLVP AIYLIFYLGL 450
MF 452
Length:452
Mass (Da):49,940
Last modified:November 1, 1998 - v1
Checksum:i4067DB59EC184C7A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16474 Genomic DNA. Translation: CAA76256.1.
PIRiC71391.
RefSeqiNP_007546.1. NC_001912.1.

Genome annotation databases

GeneIDi808213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16474 Genomic DNA. Translation: CAA76256.1 .
PIRi C71391.
RefSeqi NP_007546.1. NC_001912.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808213.

Organism-specific databases

CTDi 4538.

Phylogenomic databases

HOVERGENi HBG093667.

Family and domain databases

InterProi IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view ]
PRINTSi PR01437. NUOXDRDTASE4.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the amphioxus (Branchiostoma lanceolatum) mitochondrial genome: relations to vertebrates."
    Spruyt N., Delarbre C., Gachelin G., Laudet V.
    Nucleic Acids Res. 26:3279-3285(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiNU4M_BRALA
AccessioniPrimary (citable) accession number: O79421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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