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O79417

- COX2_BRALA

UniProt

O79417 - COX2_BRALA

Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi161 – 1611Copper ACurated
    Metal bindingi196 – 1961Copper ACurated
    Metal bindingi200 – 2001Copper ACurated
    Metal bindingi204 – 2041Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:COII
    Encoded oniMitochondrion
    OrganismiBranchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
    Taxonomic identifieri7740 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239Cytochrome c oxidase subunit 2PRO_0000183519Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO79417.
    SMRiO79417. Positions 1-226.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini83 – 239157Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4822HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8220HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG012727.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O79417-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATPAQLGLM DAASPVMEEM IYFHDHVMLV LILITCLIFY SMLVLISSKY    50
    IYRFLTDGHV IETVWTVIPA IILVVVALPS LKLLYLTDEL DNPQLTIKSV 100
    GHQWYWSYEY TDYYDIEFDS YMLPLGDLSK GDARLLEVDN RVVLPVDTSV 150
    RVLVTAADVI HSWTVPSLGL KMDAVPGRLN QLALQCSRVG TFYGQCSEIC 200
    GANHSFMPIV IEAVPVEVFE GWCDMMLDEE SLGSLNMKR 239
    Length:239
    Mass (Da):26,951
    Last modified:November 1, 1998 - v1
    Checksum:i8B0BD35AF34BCFC7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16474 Genomic DNA. Translation: CAA76250.1.
    PIRiE71390.
    RefSeqiNP_007540.1. NC_001912.1.

    Genome annotation databases

    GeneIDi808207.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16474 Genomic DNA. Translation: CAA76250.1 .
    PIRi E71390.
    RefSeqi NP_007540.1. NC_001912.1.

    3D structure databases

    ProteinModelPortali O79417.
    SMRi O79417. Positions 1-226.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 808207.

    Organism-specific databases

    CTDi 4513.

    Phylogenomic databases

    HOVERGENi HBG012727.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of the amphioxus (Branchiostoma lanceolatum) mitochondrial genome: relations to vertebrates."
      Spruyt N., Delarbre C., Gachelin G., Laudet V.
      Nucleic Acids Res. 26:3279-3285(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX2_BRALA
    AccessioniPrimary (citable) accession number: O79417
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3