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O79413 (CYB_SCYCA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene names
Name:mt-cyb
Synonyms:cob, cytb, mtcyb
Encoded onMitochondrion
OrganismScyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Taxonomic identifier7830 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Galeomorphii › Galeoidea › Carcharhiniformes › Scyliorhinidae › Scyliorhinus

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.

Cofactor

Binds 2 heme groups non-covalently By similarity.

Subunit structure

The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.

Sequence similarities

Belongs to the cytochrome b family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Cytochrome b
PRO_0000061532

Regions

Transmembrane34 – 5421Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane179 – 19921Helical; Potential
Transmembrane230 – 25021Helical; Potential
Transmembrane262 – 28221Helical; Potential
Transmembrane289 – 30921Helical; Potential
Transmembrane324 – 34421Helical; Potential
Transmembrane349 – 36921Helical; Potential

Sites

Metal binding841Iron 1 (heme b562 axial ligand)
Metal binding981Iron 2 (heme b566 axial ligand)
Metal binding1831Iron 1 (heme b562 axial ligand)
Metal binding1971Iron 2 (heme b566 axial ligand)

Sequences

Sequence LengthMass (Da)Tools
O79413 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: C4B457072A56D0C5

FASTA38143,103
        10         20         30         40         50         60 
MATNIRKTHP LLKIVNHALI DLPAPSNISV WWNFGSLLGL CLIMQIITGL FLAMHYTADI 

        70         80         90        100        110        120 
SMAFSSVIHI SRDVNYGWLM RNIHAYGASF FFICIYLHIA RGLYYGSYLN KEAWNIGVVL 

       130        140        150        160        170        180 
LFLLMATAFV GYVLPWGQMS FWGATVITNL LSAFPYIGNL LVQWIWGGFS VDNATLTRFF 

       190        200        210        220        230        240 
AFHFLLPFLI LALSVIHILF LHETGANNPM GINSNTDKIS FHPYFSYKDL FGFLIVITLL 

       250        260        270        280        290        300 
ATLALFMPNL LGDAENFIPA NPLVTPLHIQ PEWYFLFAYA ILRSIPNKLG GVLALLFSIF 

       310        320        330        340        350        360 
ILLLVPLLHT SKLRSNIFRP LTQIFFWSLV TNAIILTWIG GQPVEQPFIM VGQIASVAYF 

       370        380 
SLFLFVIPIT SWCENKFLSL N

« Hide

References

[1]"The complete nucleotide sequence of the mitochondrial DNA of the dogfish, Scyliorhinus canicula."
Delarbre C., Spruyt N., Delmarre C., Gallut C., Barriel V., Janvier P., Laudet V., Gachelin G.
Genetics 150:331-344(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y16067 Genomic DNA. Translation: CAA76031.1.
PIRT11312.
RefSeqNP_007626.1. NC_001950.1.

3D structure databases

ProteinModelPortalO79413.
SMRO79413. Positions 1-379.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808292.

Organism-specific databases

CTD4519.

Phylogenomic databases

HOVERGENHBG017694.
ProtClustDBMTH00191.

Family and domain databases

Gene3D1.20.810.10. 1 hit.
InterProIPR016175. Cyt_b/b6.
IPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PANTHERPTHR19271. PTHR19271. 1 hit.
PfamPF00032. Cytochrom_B_C. 1 hit.
PF13631. Cytochrom_B_N_2. 1 hit.
[Graphical view]
SUPFAMSSF81648. Cytochrome_b/b6_C. 1 hit.
SSF81342. Transmembr_di-haem_cytochrome. 1 hit.
PROSITEPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYB_SCYCA
AccessionPrimary (citable) accession number: O79413
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: May 29, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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