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O79410

- NU4M_SCYCA

UniProt

O79410 - NU4M_SCYCA

Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MTND4

Organism
Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
    Alternative name(s):
    NADH dehydrogenase subunit 4
    Gene namesi
    Name:MTND4
    Synonyms:NAD4, NADH4, ND4
    Encoded oniMitochondrion
    OrganismiScyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
    Taxonomic identifieri7830 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiGaleomorphiiGaleoideaCarcharhiniformesScyliorhinidaeScyliorhinus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 460460NADH-ubiquinone oxidoreductase chain 4PRO_0000117985Add
    BLAST

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei286 – 30621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei343 – 36220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei394 – 41421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei436 – 45621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 4 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG093667.

    Family and domain databases

    InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    IPR000260. NADH_UbQ_OxRdtase_chain4_N.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    PF01059. Oxidored_q5_N. 1 hit.
    [Graphical view]
    PRINTSiPR01437. NUOXDRDTASE4.
    TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O79410-1 [UniParc]FASTAAdd to Basket

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    MLKILIPTIM LFPTTWFMNK KWLWSSITTH SLLISLLSLS WFKWNMDIGW    50
    DFSNQYLAID PLSAPLLILT CWLLPLMILA SQNHITPEPL TRQRIYISLL 100
    ISLQVFLIMA FSATEMILFY IMFEATLIPT LIIITRWGNQ TERLNAGTYF 150
    LFYTLIGSLP LLIALLFMQN DLNTLSMFII QYSHLPNPSS WANKFWWTAC 200
    LIAFLVKMPL YGVHLWLPKA HVEAPIAGSM ILAAVLLKLG GYGMMRIIIM 250
    LNPITKEMAY PFIILAIWGI VMTSSICLRQ TDLKSMIAYS SVSHMGLVAG 300
    AILIQTPWSF AGAITLMIAH GLVSSALFCL ANTNYERIHS RTLLLARGVQ 350
    VILPLMATWW LLANLANLAL PPSPNLVGEL LIISSLFNWS NWTILLTGIG 400
    VLITASYSLY MFLMTQRGLT SKHLMNLNPS HTREHLLLTL HVLPVLLLIL 450
    KPELIWGWTF 460
    Length:460
    Mass (Da):52,149
    Last modified:November 1, 1998 - v1
    Checksum:i44E7A8A528AFE366
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16067 Genomic DNA. Translation: CAA76028.1.
    PIRiT11309.
    RefSeqiNP_007623.1. NC_001950.1.

    Genome annotation databases

    GeneIDi808293.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16067 Genomic DNA. Translation: CAA76028.1 .
    PIRi T11309.
    RefSeqi NP_007623.1. NC_001950.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 808293.

    Organism-specific databases

    CTDi 4538.

    Phylogenomic databases

    HOVERGENi HBG093667.

    Family and domain databases

    InterProi IPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    IPR000260. NADH_UbQ_OxRdtase_chain4_N.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    PF01059. Oxidored_q5_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01437. NUOXDRDTASE4.
    TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete nucleotide sequence of the mitochondrial DNA of the dogfish, Scyliorhinus canicula."
      Delarbre C., Spruyt N., Delmarre C., Gallut C., Barriel V., Janvier P., Laudet V., Gachelin G.
      Genetics 150:331-344(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Muscle.

    Entry informationi

    Entry nameiNU4M_SCYCA
    AccessioniPrimary (citable) accession number: O79410
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3