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O79410 (NU4M_SCYCA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:MTND4
Synonyms:NAD4, NADH4, ND4
Encoded onMitochondrion
OrganismScyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Taxonomic identifier7830 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiGaleomorphiiGaleoideaCarcharhiniformesScyliorhinidaeScyliorhinus

Protein attributes

Sequence length460 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 460460NADH-ubiquinone oxidoreductase chain 4
PRO_0000117985

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane59 – 7921Helical; Potential
Transmembrane94 – 11320Helical; Potential
Transmembrane117 – 13923Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane195 – 21521Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane286 – 30621Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane343 – 36220Helical; Potential
Transmembrane394 – 41421Helical; Potential
Transmembrane436 – 45621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O79410 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 44E7A8A528AFE366

FASTA46052,149
        10         20         30         40         50         60 
MLKILIPTIM LFPTTWFMNK KWLWSSITTH SLLISLLSLS WFKWNMDIGW DFSNQYLAID 

        70         80         90        100        110        120 
PLSAPLLILT CWLLPLMILA SQNHITPEPL TRQRIYISLL ISLQVFLIMA FSATEMILFY 

       130        140        150        160        170        180 
IMFEATLIPT LIIITRWGNQ TERLNAGTYF LFYTLIGSLP LLIALLFMQN DLNTLSMFII 

       190        200        210        220        230        240 
QYSHLPNPSS WANKFWWTAC LIAFLVKMPL YGVHLWLPKA HVEAPIAGSM ILAAVLLKLG 

       250        260        270        280        290        300 
GYGMMRIIIM LNPITKEMAY PFIILAIWGI VMTSSICLRQ TDLKSMIAYS SVSHMGLVAG 

       310        320        330        340        350        360 
AILIQTPWSF AGAITLMIAH GLVSSALFCL ANTNYERIHS RTLLLARGVQ VILPLMATWW 

       370        380        390        400        410        420 
LLANLANLAL PPSPNLVGEL LIISSLFNWS NWTILLTGIG VLITASYSLY MFLMTQRGLT 

       430        440        450        460 
SKHLMNLNPS HTREHLLLTL HVLPVLLLIL KPELIWGWTF 

« Hide

References

[1]"The complete nucleotide sequence of the mitochondrial DNA of the dogfish, Scyliorhinus canicula."
Delarbre C., Spruyt N., Delmarre C., Gallut C., Barriel V., Janvier P., Laudet V., Gachelin G.
Genetics 150:331-344(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y16067 Genomic DNA. Translation: CAA76028.1.
PIRT11309.
RefSeqNP_007623.1. NC_001950.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808293.

Organism-specific databases

CTD4538.

Phylogenomic databases

HOVERGENHBG093667.
ProtClustDBMTH00206.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4M_SCYCA
AccessionPrimary (citable) accession number: O79410
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families