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O79410

- NU4M_SCYCA

UniProt

O79410 - NU4M_SCYCA

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Protein
NADH-ubiquinone oxidoreductase chain 4
Gene
MTND4, NAD4, NADH4, ND4
Organism
Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MTND4
Synonyms:NAD4, NADH4, ND4
Encoded oniMitochondrion
OrganismiScyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Taxonomic identifieri7830 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiGaleomorphiiGaleoideaCarcharhiniformesScyliorhinidaeScyliorhinus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221Helical; Reviewed prediction
Add
BLAST
Transmembranei59 – 7921Helical; Reviewed prediction
Add
BLAST
Transmembranei94 – 11320Helical; Reviewed prediction
Add
BLAST
Transmembranei117 – 13923Helical; Reviewed prediction
Add
BLAST
Transmembranei148 – 16821Helical; Reviewed prediction
Add
BLAST
Transmembranei195 – 21521Helical; Reviewed prediction
Add
BLAST
Transmembranei231 – 25121Helical; Reviewed prediction
Add
BLAST
Transmembranei258 – 27821Helical; Reviewed prediction
Add
BLAST
Transmembranei286 – 30621Helical; Reviewed prediction
Add
BLAST
Transmembranei310 – 33021Helical; Reviewed prediction
Add
BLAST
Transmembranei343 – 36220Helical; Reviewed prediction
Add
BLAST
Transmembranei394 – 41421Helical; Reviewed prediction
Add
BLAST
Transmembranei436 – 45621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460NADH-ubiquinone oxidoreductase chain 4
PRO_0000117985Add
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O79410-1 [UniParc]FASTAAdd to Basket

« Hide

MLKILIPTIM LFPTTWFMNK KWLWSSITTH SLLISLLSLS WFKWNMDIGW    50
DFSNQYLAID PLSAPLLILT CWLLPLMILA SQNHITPEPL TRQRIYISLL 100
ISLQVFLIMA FSATEMILFY IMFEATLIPT LIIITRWGNQ TERLNAGTYF 150
LFYTLIGSLP LLIALLFMQN DLNTLSMFII QYSHLPNPSS WANKFWWTAC 200
LIAFLVKMPL YGVHLWLPKA HVEAPIAGSM ILAAVLLKLG GYGMMRIIIM 250
LNPITKEMAY PFIILAIWGI VMTSSICLRQ TDLKSMIAYS SVSHMGLVAG 300
AILIQTPWSF AGAITLMIAH GLVSSALFCL ANTNYERIHS RTLLLARGVQ 350
VILPLMATWW LLANLANLAL PPSPNLVGEL LIISSLFNWS NWTILLTGIG 400
VLITASYSLY MFLMTQRGLT SKHLMNLNPS HTREHLLLTL HVLPVLLLIL 450
KPELIWGWTF 460
Length:460
Mass (Da):52,149
Last modified:November 1, 1998 - v1
Checksum:i44E7A8A528AFE366
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16067 Genomic DNA. Translation: CAA76028.1.
PIRiT11309.
RefSeqiNP_007623.1. NC_001950.1.

Genome annotation databases

GeneIDi808293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16067 Genomic DNA. Translation: CAA76028.1 .
PIRi T11309.
RefSeqi NP_007623.1. NC_001950.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808293.

Organism-specific databases

CTDi 4538.

Phylogenomic databases

HOVERGENi HBG093667.

Family and domain databases

InterProi IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view ]
PRINTSi PR01437. NUOXDRDTASE4.
TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence of the mitochondrial DNA of the dogfish, Scyliorhinus canicula."
    Delarbre C., Spruyt N., Delmarre C., Gallut C., Barriel V., Janvier P., Laudet V., Gachelin G.
    Genetics 150:331-344(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Muscle.

Entry informationi

Entry nameiNU4M_SCYCA
AccessioniPrimary (citable) accession number: O79410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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