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O79407

- COX3_SCYCA

UniProt

O79407 - COX3_SCYCA

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Protein
Cytochrome c oxidase subunit 3
Gene
MT-CO3, COIII, COXIII, MTCO3
Organism
Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded oniMitochondrion
OrganismiScyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Taxonomic identifieri7830 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiGaleomorphiiGaleoideaCarcharhiniformesScyliorhinidaeScyliorhinus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121Helical; Reviewed prediction
Add
BLAST
Transmembranei81 – 10121Helical; Reviewed prediction
Add
BLAST
Transmembranei127 – 14721Helical; Reviewed prediction
Add
BLAST
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Transmembranei197 – 21721Helical; Reviewed prediction
Add
BLAST
Transmembranei239 – 25921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Cytochrome c oxidase subunit 3
PRO_0000183852Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO79407.
SMRiO79407. Positions 1-261.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016686.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O79407-1 [UniParc]FASTAAdd to Basket

« Hide

MAHQAHPYHM VDPSPWPLTG ATAALLMTSG LAIWFHFHSL LLLYLGLTLL    50
LLTMIQWWRD IIREGTFQGH HTPPVQKGLR YGMILFIVSE VFFFLGFFWA 100
FYHSSLAPTP ELGGCWPPTG INPLDPFEVP LLNTAVLLAS GVTVTWAHHG 150
LMEGNRKEAI QALTLTIILG VYFTALQAME YYEAPFTIAD GVYGTTFFVA 200
TGFHGLHVII GSTFLAVCLL RQVLYHFTSE HHFGFEAAAW YWHFVDVVWL 250
FLYVSIYWWG S 261
Length:261
Mass (Da):29,612
Last modified:November 1, 1998 - v1
Checksum:i711CDAF8639B0837
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16067 Genomic DNA. Translation: CAA76025.1.
PIRiT11306.
RefSeqiNP_007620.1. NC_001950.1.

Genome annotation databases

GeneIDi808297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16067 Genomic DNA. Translation: CAA76025.1 .
PIRi T11306.
RefSeqi NP_007620.1. NC_001950.1.

3D structure databases

ProteinModelPortali O79407.
SMRi O79407. Positions 1-261.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808297.

Organism-specific databases

CTDi 4514.

Phylogenomic databases

HOVERGENi HBG016686.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence of the mitochondrial DNA of the dogfish, Scyliorhinus canicula."
    Delarbre C., Spruyt N., Delmarre C., Gallut C., Barriel V., Janvier P., Laudet V., Gachelin G.
    Genetics 150:331-344(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Muscle.

Entry informationi

Entry nameiCOX3_SCYCA
AccessioniPrimary (citable) accession number: O79407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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