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O79407 (COX3_SCYCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded onMitochondrion
OrganismScyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Taxonomic identifier7830 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Galeomorphii › Galeoidea › Carcharhiniformes › Scyliorhinidae › Scyliorhinus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processaerobic electron transport chain

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Cytochrome c oxidase subunit 3
PRO_0000183852

Regions

Transmembrane31 – 5121Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane239 – 25921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O79407 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 711CDAF8639B0837

FASTA26129,612
        10         20         30         40         50         60 
MAHQAHPYHM VDPSPWPLTG ATAALLMTSG LAIWFHFHSL LLLYLGLTLL LLTMIQWWRD 

        70         80         90        100        110        120 
IIREGTFQGH HTPPVQKGLR YGMILFIVSE VFFFLGFFWA FYHSSLAPTP ELGGCWPPTG 

       130        140        150        160        170        180 
INPLDPFEVP LLNTAVLLAS GVTVTWAHHG LMEGNRKEAI QALTLTIILG VYFTALQAME 

       190        200        210        220        230        240 
YYEAPFTIAD GVYGTTFFVA TGFHGLHVII GSTFLAVCLL RQVLYHFTSE HHFGFEAAAW 

       250        260 
YWHFVDVVWL FLYVSIYWWG S

« Hide

References

[1]"The complete nucleotide sequence of the mitochondrial DNA of the dogfish, Scyliorhinus canicula."
Delarbre C., Spruyt N., Delmarre C., Gallut C., Barriel V., Janvier P., Laudet V., Gachelin G.
Genetics 150:331-344(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y16067 Genomic DNA. Translation: CAA76025.1.
PIRT11306.
RefSeqNP_007620.1. NC_001950.1.

3D structure databases

ProteinModelPortalO79407.
SMRO79407. Positions 1-261.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808297.

Organism-specific databases

CTD4514.

Phylogenomic databases

HOVERGENHBG016686.
ProtClustDBMTH00189.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. CytC_oxdse_III. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_SCYCA
AccessionPrimary (citable) accession number: O79407
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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