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O79404

- COX2_SCYCA

UniProt

O79404 - COX2_SCYCA

Protein

Cytochrome c oxidase subunit 2

Gene

MT-CO2

Organism
Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi161 – 1611Copper ACurated
    Metal bindingi196 – 1961Copper ACurated
    Metal bindingi200 – 2001Copper ACurated
    Metal bindingi204 – 2041Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:MT-CO2
    Synonyms:COII, COXII, MTCO2
    Encoded oniMitochondrion
    OrganismiScyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
    Taxonomic identifieri7830 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiGaleomorphiiGaleoideaCarcharhiniformesScyliorhinidaeScyliorhinus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 230230Cytochrome c oxidase subunit 2PRO_0000183688Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO79404.
    SMRiO79404. Positions 1-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini83 – 230148Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4822HelicalCuratedAdd
    BLAST
    Transmembranei63 – 8220HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG012727.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O79404-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHPSQLGFQ DAASPVMEEL IHFHDHTLMI VFLISTLVLY IITAMVSTKL    50
    TNKYILDSQE IEIVWTILPA IILIMIALPS LRILYLMDEI NDPHLTIKAM 100
    GHQWYWSYEY TDYEDLGFDS YMIQTQDLTP GQFRLLETDH RMVVPMESPI 150
    RVLVSAEDVL HAWAVPALGV KMDAVPGRLN QTAFIISRPG VYYGQCSEIC 200
    GANHSFMPIV VEAVPLEHFE TWSSLMLEEA 230
    Length:230
    Mass (Da):26,198
    Last modified:November 1, 1998 - v1
    Checksum:i89311D5BD5BF7397
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16067 Genomic DNA. Translation: CAA76022.1.
    PIRiT11303.
    RefSeqiNP_007617.1. NC_001950.1.

    Genome annotation databases

    GeneIDi808299.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16067 Genomic DNA. Translation: CAA76022.1 .
    PIRi T11303.
    RefSeqi NP_007617.1. NC_001950.1.

    3D structure databases

    ProteinModelPortali O79404.
    SMRi O79404. Positions 1-227.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 808299.

    Organism-specific databases

    CTDi 4513.

    Phylogenomic databases

    HOVERGENi HBG012727.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete nucleotide sequence of the mitochondrial DNA of the dogfish, Scyliorhinus canicula."
      Delarbre C., Spruyt N., Delmarre C., Gallut C., Barriel V., Janvier P., Laudet V., Gachelin G.
      Genetics 150:331-344(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Muscle.

    Entry informationi

    Entry nameiCOX2_SCYCA
    AccessioniPrimary (citable) accession number: O79404
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3