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O79404 (COX2_SCYCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded onMitochondrion
OrganismScyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Taxonomic identifier7830 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiGaleomorphiiGaleoideaCarcharhiniformesScyliorhinidaeScyliorhinus

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 230230Cytochrome c oxidase subunit 2
PRO_0000183688

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4822Helical; Probable
Topological domain49 – 6214Mitochondrial matrix Potential
Transmembrane63 – 8220Helical; Probable
Topological domain83 – 230148Mitochondrial intermembrane Potential

Sites

Metal binding1611Copper A Probable
Metal binding1961Copper A Probable
Metal binding2001Copper A Probable
Metal binding2041Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
O79404 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 89311D5BD5BF7397

FASTA23026,198
        10         20         30         40         50         60 
MAHPSQLGFQ DAASPVMEEL IHFHDHTLMI VFLISTLVLY IITAMVSTKL TNKYILDSQE 

        70         80         90        100        110        120 
IEIVWTILPA IILIMIALPS LRILYLMDEI NDPHLTIKAM GHQWYWSYEY TDYEDLGFDS 

       130        140        150        160        170        180 
YMIQTQDLTP GQFRLLETDH RMVVPMESPI RVLVSAEDVL HAWAVPALGV KMDAVPGRLN 

       190        200        210        220        230 
QTAFIISRPG VYYGQCSEIC GANHSFMPIV VEAVPLEHFE TWSSLMLEEA 

« Hide

References

[1]"The complete nucleotide sequence of the mitochondrial DNA of the dogfish, Scyliorhinus canicula."
Delarbre C., Spruyt N., Delmarre C., Gallut C., Barriel V., Janvier P., Laudet V., Gachelin G.
Genetics 150:331-344(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y16067 Genomic DNA. Translation: CAA76022.1.
PIRT11303.
RefSeqNP_007617.1. NC_001950.1.

3D structure databases

ProteinModelPortalO79404.
SMRO79404. Positions 1-227.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808299.

Organism-specific databases

CTD4513.

Phylogenomic databases

HOVERGENHBG012727.
ProtClustDBMTH00185.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_SCYCA
AccessionPrimary (citable) accession number: O79404
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families