ID NU4M_SHEEP Reviewed; 459 AA. AC O78755; DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 27-MAR-2024, entry version 110. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4; DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03905}; DE AltName: Full=NADH dehydrogenase subunit 4; GN Name=MT-ND4; Synonyms=MTND4, NADH4, ND4; OS Ovis aries (Sheep). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Caprinae; Ovis. OX NCBI_TaxID=9940; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Merinolandschaf {ECO:0000312|Proteomes:UP000002356}; RC TISSUE=Liver; RX PubMed=9767689; DOI=10.1007/pl00006401; RA Hiendleder S., Lewalski H., Wassmuth R., Janke A.; RT "The complete mitochondrial DNA sequence of the domestic sheep (Ovis aries) RT and comparison with the other major ovine haplotype."; RL J. Mol. Evol. 47:441-448(1998). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Essential for the catalytic activity and assembly of complex CC I. {ECO:0000250|UniProtKB:P03905}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000250|UniProtKB:P03905}; CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex CC I) which is composed of 45 different subunits. CC {ECO:0000250|UniProtKB:P03910}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000250|UniProtKB:P03910}; Multi-pass membrane protein CC {ECO:0000255}. CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF010406; AAD10104.1; -; Genomic_DNA. DR PIR; T11059; T11059. DR RefSeq; NP_008415.1; NC_001941.1. DR PDB; 5LNK; EM; 3.90 A; M=1-459. DR PDB; 6Q9B; EM; 3.90 A; D4=1-459. DR PDB; 6QA9; EM; 4.10 A; D4=1-459. DR PDB; 6QBX; EM; 4.20 A; D4=1-459. DR PDB; 6QC2; EM; 4.20 A; D4=1-459. DR PDB; 6QC3; EM; 4.20 A; D4=1-459. DR PDB; 6QC4; EM; 4.60 A; D4=1-459. DR PDB; 6QC5; EM; 4.30 A; D4=1-459. DR PDB; 6QC6; EM; 4.10 A; D4=1-459. DR PDB; 6QC7; EM; 4.40 A; D4=1-459. DR PDB; 6QC8; EM; 4.20 A; D4=1-459. DR PDB; 6QC9; EM; 5.70 A; D4=1-459. DR PDB; 6QCA; EM; 6.20 A; D4=1-459. DR PDB; 6QCF; EM; 6.50 A; D4=1-459. DR PDB; 6ZKA; EM; 2.50 A; M=1-459. DR PDB; 6ZKB; EM; 2.90 A; M=1-459. DR PDB; 6ZKC; EM; 3.10 A; M=1-459. DR PDB; 6ZKD; EM; 2.70 A; M=1-459. DR PDB; 6ZKE; EM; 2.60 A; M=1-459. DR PDB; 6ZKF; EM; 2.80 A; M=1-459. DR PDB; 6ZKG; EM; 3.40 A; M=1-459. DR PDB; 6ZKH; EM; 3.00 A; M=1-459. DR PDB; 6ZKI; EM; 2.80 A; M=1-459. DR PDB; 6ZKJ; EM; 3.00 A; M=1-459. DR PDB; 6ZKK; EM; 3.70 A; M=1-459. DR PDB; 6ZKL; EM; 3.10 A; M=1-459. DR PDB; 6ZKM; EM; 2.80 A; M=1-459. DR PDB; 6ZKN; EM; 2.90 A; M=1-459. DR PDB; 6ZKO; EM; 3.80 A; M=1-459. DR PDB; 6ZKP; EM; 3.20 A; M=1-459. DR PDB; 6ZKQ; EM; 3.30 A; M=1-459. DR PDB; 6ZKR; EM; 3.50 A; M=1-459. DR PDB; 6ZKS; EM; 3.10 A; M=1-459. DR PDB; 6ZKT; EM; 2.80 A; M=1-459. DR PDB; 6ZKU; EM; 3.00 A; M=1-459. DR PDB; 6ZKV; EM; 2.90 A; M=1-459. DR PDB; 7ZD6; EM; 3.16 A; M=1-459. DR PDB; 7ZDH; EM; 3.46 A; M=1-459. DR PDB; 7ZDJ; EM; 3.25 A; M=1-459. DR PDB; 7ZDM; EM; 3.44 A; M=1-459. DR PDB; 7ZDP; EM; 3.88 A; M=1-459. DR PDB; 7ZEB; EM; 3.80 A; M=1-459. DR PDBsum; 5LNK; -. DR PDBsum; 6Q9B; -. DR PDBsum; 6QA9; -. DR PDBsum; 6QBX; -. DR PDBsum; 6QC2; -. DR PDBsum; 6QC3; -. DR PDBsum; 6QC4; -. DR PDBsum; 6QC5; -. DR PDBsum; 6QC6; -. DR PDBsum; 6QC7; -. DR PDBsum; 6QC8; -. DR PDBsum; 6QC9; -. DR PDBsum; 6QCA; -. DR PDBsum; 6QCF; -. DR PDBsum; 6ZKA; -. DR PDBsum; 6ZKB; -. DR PDBsum; 6ZKC; -. DR PDBsum; 6ZKD; -. DR PDBsum; 6ZKE; -. DR PDBsum; 6ZKF; -. DR PDBsum; 6ZKG; -. DR PDBsum; 6ZKH; -. DR PDBsum; 6ZKI; -. DR PDBsum; 6ZKJ; -. DR PDBsum; 6ZKK; -. DR PDBsum; 6ZKL; -. DR PDBsum; 6ZKM; -. DR PDBsum; 6ZKN; -. DR PDBsum; 6ZKO; -. DR PDBsum; 6ZKP; -. DR PDBsum; 6ZKQ; -. DR PDBsum; 6ZKR; -. DR PDBsum; 6ZKS; -. DR PDBsum; 6ZKT; -. DR PDBsum; 6ZKU; -. DR PDBsum; 6ZKV; -. DR PDBsum; 7ZD6; -. DR PDBsum; 7ZDH; -. DR PDBsum; 7ZDJ; -. DR PDBsum; 7ZDM; -. DR PDBsum; 7ZDP; -. DR PDBsum; 7ZEB; -. DR AlphaFoldDB; O78755; -. DR EMDB; EMD-11242; -. DR EMDB; EMD-11243; -. DR EMDB; EMD-11244; -. DR EMDB; EMD-11245; -. DR EMDB; EMD-11246; -. DR EMDB; EMD-11247; -. DR EMDB; EMD-11248; -. DR EMDB; EMD-11249; -. DR EMDB; EMD-11250; -. DR EMDB; EMD-11251; -. DR EMDB; EMD-11252; -. DR EMDB; EMD-11253; -. DR EMDB; EMD-11254; -. DR EMDB; EMD-11255; -. DR EMDB; EMD-11256; -. DR EMDB; EMD-11257; -. DR EMDB; EMD-11258; -. DR EMDB; EMD-11259; -. DR EMDB; EMD-11260; -. DR EMDB; EMD-11261; -. DR EMDB; EMD-11262; -. DR EMDB; EMD-11263; -. DR EMDB; EMD-14637; -. DR EMDB; EMD-14648; -. DR EMDB; EMD-14651; -. DR EMDB; EMD-14658; -. DR EMDB; EMD-14664; -. DR EMDB; EMD-14688; -. DR EMDB; EMD-4479; -. DR EMDB; EMD-4482; -. DR EMDB; EMD-4493; -. DR EMDB; EMD-4494; -. DR EMDB; EMD-4495; -. DR EMDB; EMD-4496; -. DR EMDB; EMD-4497; -. DR EMDB; EMD-4498; -. DR EMDB; EMD-4499; -. DR EMDB; EMD-4500; -. DR EMDB; EMD-4501; -. DR EMDB; EMD-4502; -. DR EMDB; EMD-4505; -. DR EMDB; EMD-8128; -. DR SMR; O78755; -. DR STRING; 9940.ENSOARP00000000010; -. DR PaxDb; 9940-ENSOARP00000000010; -. DR Ensembl; ENSOART00000000028.1; ENSOARP00000000010.1; ENSOARG00000000028.1. DR Ensembl; ENSOART00020000027; ENSOARP00020000009; ENSOARG00020000027. DR GeneID; 808257; -. DR KEGG; oas:808257; -. DR CTD; 4538; -. DR eggNOG; KOG4845; Eukaryota. DR HOGENOM; CLU_007100_4_0_1; -. DR OMA; ITRWGNQ; -. DR OrthoDB; 1946151at2759; -. DR Proteomes; UP000002356; Mitochondrion. DR Bgee; ENSOARG00000000028; Expressed in cardiac muscle tissue of left auricle and 55 other cell types or tissues. DR ExpressionAtlas; O78755; baseline. DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB. DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB. DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB. DR InterPro; IPR000260; NADH4_N. DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4. DR InterPro; IPR003918; NADH_UbQ_OxRdtase. DR InterPro; IPR001750; ND/Mrp_mem. DR NCBIfam; TIGR01972; NDH_I_M; 1. DR PANTHER; PTHR43507; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; 1. DR PANTHER; PTHR43507:SF20; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; 1. DR Pfam; PF01059; Oxidored_q5_N; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01437; NUOXDRDTASE4. PE 1: Evidence at protein level; KW 3D-structure; Electron transport; Membrane; Mitochondrion; KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain; KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone. FT CHAIN 1..459 FT /note="NADH-ubiquinone oxidoreductase chain 4" FT /id="PRO_0000117986" FT TRANSMEM 22..42 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 60..80 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 98..118 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 147..167 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 196..216 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 224..244 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 256..276 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 284..303 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 308..330 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 351..371 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 391..411 FT /note="Helical" FT /evidence="ECO:0000255" FT HELIX 2..16 FT /evidence="ECO:0007829|PDB:6ZKA" FT TURN 20..22 FT /evidence="ECO:0007829|PDB:6ZKE" FT HELIX 23..37 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 38..42 FT /evidence="ECO:0007829|PDB:6ZKA" FT STRAND 46..48 FT /evidence="ECO:0007829|PDB:6ZKA" FT STRAND 53..58 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 62..80 FT /evidence="ECO:0007829|PDB:6ZKA" FT TURN 81..86 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 89..110 FT /evidence="ECO:0007829|PDB:6ZKA" FT STRAND 112..114 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 115..124 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 126..136 FT /evidence="ECO:0007829|PDB:6ZKA" FT STRAND 138..140 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 142..171 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 176..182 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 190..206 FT /evidence="ECO:0007829|PDB:6ZKA" FT TURN 210..212 FT /evidence="ECO:0007829|PDB:6ZKC" FT HELIX 213..215 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 216..222 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 225..233 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 235..246 FT /evidence="ECO:0007829|PDB:6ZKA" FT TURN 247..251 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 254..277 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 282..303 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 306..337 FT /evidence="ECO:0007829|PDB:6ZKA" FT TURN 342..344 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 348..351 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 353..366 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 373..388 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 392..415 FT /evidence="ECO:0007829|PDB:6ZKA" FT STRAND 416..418 FT /evidence="ECO:0007829|PDB:6ZKE" FT STRAND 421..423 FT /evidence="ECO:0007829|PDB:6ZKE" FT HELIX 431..446 FT /evidence="ECO:0007829|PDB:6ZKA" FT TURN 447..449 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 451..454 FT /evidence="ECO:0007829|PDB:6ZKA" FT HELIX 456..458 FT /evidence="ECO:0007829|PDB:6ZKI" SQ SEQUENCE 459 AA; 52026 MW; 899F37F114A96C71 CRC64; MLKYIIPTMM LMPLTWLSKN SMIWINTTLH SLLISLTSLL LLNQFGDNSL NFSLTFFSDS LSTPLLILTM WLLPLMLMAS QHHLSKENLA RKKLFISMLI LLQLFLIMTF TATELIFFYI MFEATLVPTL IIITRWGNQT ERLNAGLYFL FYTLAGSLPL LVALIYIQNT MGSLNFLILQ YWVQPMPNSW SNTFMWLACM MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAILLKLGG YGMMRITLLL NPITDFMAYP FIMLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA ILIQTPWSYM GATALMIAHG LTSSMLFCLA NSNYERVHSR TMILARGLQT LLPLMAAWWL LASLTNLALP PSINLIGELF VVMSTFSWSN ITIILMGLNM VITALYSLYM LITTQRGKHT HHINNILPSF TRENALMSLH MLPLLLLSLN PKIILGPLY //