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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei98 – 11821HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence AnalysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence AnalysisAdd
BLAST
Transmembranei284 – 30320HelicalSequence AnalysisAdd
BLAST
Transmembranei308 – 33023HelicalSequence AnalysisAdd
BLAST
Transmembranei351 – 37121HelicalSequence AnalysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459NADH-ubiquinone oxidoreductase chain 4PRO_0000117986Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000111316.
HOVERGENiHBG093667.
KOiK03881.
OMAiMWLACMM.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O78755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKYIIPTMM LMPLTWLSKN SMIWINTTLH SLLISLTSLL LLNQFGDNSL
60 70 80 90 100
NFSLTFFSDS LSTPLLILTM WLLPLMLMAS QHHLSKENLA RKKLFISMLI
110 120 130 140 150
LLQLFLIMTF TATELIFFYI MFEATLVPTL IIITRWGNQT ERLNAGLYFL
160 170 180 190 200
FYTLAGSLPL LVALIYIQNT MGSLNFLILQ YWVQPMPNSW SNTFMWLACM
210 220 230 240 250
MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAILLKLGG YGMMRITLLL
260 270 280 290 300
NPITDFMAYP FIMLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA
310 320 330 340 350
ILIQTPWSYM GATALMIAHG LTSSMLFCLA NSNYERVHSR TMILARGLQT
360 370 380 390 400
LLPLMAAWWL LASLTNLALP PSINLIGELF VVMSTFSWSN ITIILMGLNM
410 420 430 440 450
VITALYSLYM LITTQRGKHT HHINNILPSF TRENALMSLH MLPLLLLSLN

PKIILGPLY
Length:459
Mass (Da):52,026
Last modified:November 1, 1998 - v1
Checksum:i899F37F114A96C71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010406 Genomic DNA. Translation: AAD10104.1.
PIRiT11059.
RefSeqiNP_008415.1. NC_001941.1.

Genome annotation databases

EnsembliENSOART00000000028; ENSOARP00000000010; ENSOARG00000000028.
GeneIDi808257.
KEGGioas:808257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010406 Genomic DNA. Translation: AAD10104.1.
PIRiT11059.
RefSeqiNP_008415.1. NC_001941.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOART00000000028; ENSOARP00000000010; ENSOARG00000000028.
GeneIDi808257.
KEGGioas:808257.

Organism-specific databases

CTDi4538.

Phylogenomic databases

GeneTreeiENSGT00730000111316.
HOVERGENiHBG093667.
KOiK03881.
OMAiMWLACMM.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete mitochondrial DNA sequence of the domestic sheep (Ovis aries) and comparison with the other major ovine haplotype."
    Hiendleder S., Lewalski H., Wassmuth R., Janke A.
    J. Mol. Evol. 47:441-448(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MerinolandschafImported.
    Tissue: Liver.

Entry informationi

Entry nameiNU4M_SHEEP
AccessioniPrimary (citable) accession number: O78755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: July 22, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.