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O78755 (NU4M_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded onMitochondrion
OrganismOvis aries (Sheep) [Reference proteome]
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459NADH-ubiquinone oxidoreductase chain 4
PRO_0000117986

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane98 – 11821Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane256 – 27621Helical; Potential
Transmembrane284 – 30320Helical; Potential
Transmembrane308 – 33023Helical; Potential
Transmembrane351 – 37121Helical; Potential
Transmembrane391 – 41121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O78755 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 899F37F114A96C71

FASTA45952,026
        10         20         30         40         50         60 
MLKYIIPTMM LMPLTWLSKN SMIWINTTLH SLLISLTSLL LLNQFGDNSL NFSLTFFSDS 

        70         80         90        100        110        120 
LSTPLLILTM WLLPLMLMAS QHHLSKENLA RKKLFISMLI LLQLFLIMTF TATELIFFYI 

       130        140        150        160        170        180 
MFEATLVPTL IIITRWGNQT ERLNAGLYFL FYTLAGSLPL LVALIYIQNT MGSLNFLILQ 

       190        200        210        220        230        240 
YWVQPMPNSW SNTFMWLACM MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAILLKLGG 

       250        260        270        280        290        300 
YGMMRITLLL NPITDFMAYP FIMLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA 

       310        320        330        340        350        360 
ILIQTPWSYM GATALMIAHG LTSSMLFCLA NSNYERVHSR TMILARGLQT LLPLMAAWWL 

       370        380        390        400        410        420 
LASLTNLALP PSINLIGELF VVMSTFSWSN ITIILMGLNM VITALYSLYM LITTQRGKHT 

       430        440        450 
HHINNILPSF TRENALMSLH MLPLLLLSLN PKIILGPLY 

« Hide

References

[1]"The complete mitochondrial DNA sequence of the domestic sheep (Ovis aries) and comparison with the other major ovine haplotype."
Hiendleder S., Lewalski H., Wassmuth R., Janke A.
J. Mol. Evol. 47:441-448(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Merinolandschaf.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF010406 Genomic DNA. Translation: AAD10104.1.
PIRT11059.
RefSeqNP_008415.1. NC_001941.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSOART00000000028; ENSOARP00000000010; ENSOARG00000000028.
GeneID808257.

Organism-specific databases

CTD4538.

Phylogenomic databases

HOVERGENHBG093667.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4M_SHEEP
AccessionPrimary (citable) accession number: O78755
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families