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Protein

Cytochrome c oxidase subunit 1

Gene
N/A
Organism
Spirometra erinaceieuropaei (Tapeworm) (Spirometra erinacei)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Encoded oniMitochondrionImported
OrganismiSpirometra erinaceieuropaei (Tapeworm) (Spirometra erinacei)Imported
Taxonomic identifieri99802 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesCestodaEucestodaDiphyllobothriideaDiphyllobothriidaeSpirometra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 44HelicalSequence analysisAdd BLAST24
Transmembranei64 – 86HelicalSequence analysisAdd BLAST23
Transmembranei107 – 129HelicalSequence analysisAdd BLAST23
Transmembranei149 – 173HelicalSequence analysisAdd BLAST25
Transmembranei185 – 211HelicalSequence analysisAdd BLAST27
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Transmembranei302 – 326HelicalSequence analysisAdd BLAST25
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Transmembranei378 – 397HelicalSequence analysisAdd BLAST20
Transmembranei449 – 474HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO78729
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 505COX1InterPro annotationAdd BLAST503

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

O78729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKFSFFSWL FTLDHKRVGM IYTLIGMWSG FVGLSFSVMM RVNFVEPYFN
60 70 80 90 100
VISSDCYNFL MTNHGIIMIF FFLMPVLIGG FGNYLIPLLS GLPDLNLPRL
110 120 130 140 150
NALSAWLLFP SILFLVLSMC LGAGMGWTFY PPLSSSLFSD SRGVDLLMFS
160 170 180 190 200
LHLAGLSSLL GSMNFMCTLY SAFVDNFVSR SSILLWSYLF TSILLLLTIP
210 220 230 240 250
VLAAAITMLL FDRNFGSAFF DPLGGGDPVL FQHMFWFFGH PEVYVLILPG
260 270 280 290 300
FGMVSHVCSN LGCSYDTFGF YGLLFALFSM VCLGSVVWGH HMFTVGLDVK
310 320 330 340 350
TAVFFSSVTM IIGVPTGMKV FSWLYMILNS RVSLREPVFW WVLSFIVLFT
360 370 380 390 400
MGGVTGMILS ACVLDNILHD TWFVVAHFHY VMSLGSYISI IMFFVWWWPV
410 420 430 440 450
ITGVSLNKYL LQCHCMVSNV GFNLCFFPMH YFGICGLPRR VCVYESGYAW
460 470 480 490 500
VNMLCSMGSF VSAFSGCFFI FILWESLANK NVVMGYYGSS STLLNLCWSP
510 520
VPYHSNFFVR GLFVDYSVLA F
Length:521
Mass (Da):58,794
Last modified:November 1, 1998 - v1
Checksum:iAFA356E4AA67CECB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015754 Genomic DNA Translation: BAA31704.1

Similar proteinsi

Entry informationi

Entry nameiO78729_SPIER
AccessioniPrimary (citable) accession number: O78729
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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