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Protein

Cytochrome c oxidase subunit 1

Gene
N/A
Organism
Sparganum proliferum
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Encoded oniMitochondrionImported
OrganismiSparganum proliferumImported
Taxonomic identifieri64606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesCestodaEucestodaDiphyllobothriideaDiphyllobothriidaeSparganum

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4425HelicalSequence analysisAdd
BLAST
Transmembranei65 – 8622HelicalSequence analysisAdd
BLAST
Transmembranei106 – 13025HelicalSequence analysisAdd
BLAST
Transmembranei151 – 17323HelicalSequence analysisAdd
BLAST
Transmembranei185 – 21127HelicalSequence analysisAdd
BLAST
Transmembranei243 – 26220HelicalSequence analysisAdd
BLAST
Transmembranei268 – 28922HelicalSequence analysisAdd
BLAST
Transmembranei301 – 32626HelicalSequence analysisAdd
BLAST
Transmembranei338 – 36427HelicalSequence analysisAdd
BLAST
Transmembranei371 – 39727HelicalSequence analysisAdd
BLAST
Transmembranei409 – 43224HelicalSequence analysisAdd
BLAST
Transmembranei453 – 47422HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO78728.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 505503COX1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O78728-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFSFFSWL FTLDHKRVGM IYTLMGIWSG FVGLSFSVMM RVNFVEPYFN
60 70 80 90 100
VISSDCYNFL MTNHGIIMIF FFLMPVLIGG FGNYLIPLLS GLPDLNLPRL
110 120 130 140 150
NALSAWLLFP SMLFLVLSMC LGAGMGWTFY PPLSSSLFSD SRGVDFLMFS
160 170 180 190 200
LHLAGVSSLL GSINFICTLY TAFVDSFVSR SSILLWSYLF TSILLLSTIP
210 220 230 240 250
VLAAAITMLL FDRNFGSAFF DPLGGGDPVL FQHMFWFFGH PEVYVLILPG
260 270 280 290 300
FGMVSHVCSN LGCSYDTFGF YGLLFAMFSM VCLGSVVWGH HMFTVGLDVK
310 320 330 340 350
TAVFFSSVTM IMGVPTGMKV FSWLYMILNS RVSLREPVFW WVLSFIMLFT
360 370 380 390 400
MGGVTGMILS ACVLDNILHD TWFVVAHFHY VMSLGSYMSM IIFFVWWWPV
410 420 430 440 450
ITGVSLNKYL LQCHCMVSNV GFNLCFFPMH YFGMCGLPRR VCVYESGYAW
460 470 480 490 500
MNMLCSIGSF VSAFSGCFFI FILWESLANK NVVLGYYGSS STLLNLCWSP
510 520
VPYHSNFFVR GLFVDYSVLA F
Length:521
Mass (Da):58,816
Last modified:November 1, 1998 - v1
Checksum:i531F68E0B72011C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015753 Genomic DNA. Translation: BAA31703.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015753 Genomic DNA. Translation: BAA31703.1.

3D structure databases

ProteinModelPortaliO78728.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Phylogenetic identification of Sparganum proliferum as a pseudophyllidean cestode by the sequence analyses on mitochondrial COI and nuclear sdhB genes."
    Miyadera H., Kokaze A., Kuramochi T., Kita K., Machinami R., Noya O., Alarcon de Noya B., Okomoto M., Kojima S.
    Parasitol. Int. 50:93-104(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO78728_9CEST
AccessioniPrimary (citable) accession number: O78728
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.