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Protein

Cytochrome c oxidase subunit 1

Gene
N/A
Organism
Sparganum proliferum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Encoded oniMitochondrionImported
OrganismiSparganum proliferumImported
Taxonomic identifieri64606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesCestodaEucestodaDiphyllobothriideaDiphyllobothriidaeSparganum

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 44HelicalSequence analysisAdd BLAST25
Transmembranei65 – 86HelicalSequence analysisAdd BLAST22
Transmembranei106 – 130HelicalSequence analysisAdd BLAST25
Transmembranei151 – 173HelicalSequence analysisAdd BLAST23
Transmembranei185 – 211HelicalSequence analysisAdd BLAST27
Transmembranei243 – 262HelicalSequence analysisAdd BLAST20
Transmembranei268 – 289HelicalSequence analysisAdd BLAST22
Transmembranei301 – 326HelicalSequence analysisAdd BLAST26
Transmembranei338 – 364HelicalSequence analysisAdd BLAST27
Transmembranei371 – 397HelicalSequence analysisAdd BLAST27
Transmembranei409 – 432HelicalSequence analysisAdd BLAST24
Transmembranei453 – 474HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO78728
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 505COX1InterPro annotationAdd BLAST503

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

O78728-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFSFFSWL FTLDHKRVGM IYTLMGIWSG FVGLSFSVMM RVNFVEPYFN
60 70 80 90 100
VISSDCYNFL MTNHGIIMIF FFLMPVLIGG FGNYLIPLLS GLPDLNLPRL
110 120 130 140 150
NALSAWLLFP SMLFLVLSMC LGAGMGWTFY PPLSSSLFSD SRGVDFLMFS
160 170 180 190 200
LHLAGVSSLL GSINFICTLY TAFVDSFVSR SSILLWSYLF TSILLLSTIP
210 220 230 240 250
VLAAAITMLL FDRNFGSAFF DPLGGGDPVL FQHMFWFFGH PEVYVLILPG
260 270 280 290 300
FGMVSHVCSN LGCSYDTFGF YGLLFAMFSM VCLGSVVWGH HMFTVGLDVK
310 320 330 340 350
TAVFFSSVTM IMGVPTGMKV FSWLYMILNS RVSLREPVFW WVLSFIMLFT
360 370 380 390 400
MGGVTGMILS ACVLDNILHD TWFVVAHFHY VMSLGSYMSM IIFFVWWWPV
410 420 430 440 450
ITGVSLNKYL LQCHCMVSNV GFNLCFFPMH YFGMCGLPRR VCVYESGYAW
460 470 480 490 500
MNMLCSIGSF VSAFSGCFFI FILWESLANK NVVLGYYGSS STLLNLCWSP
510 520
VPYHSNFFVR GLFVDYSVLA F
Length:521
Mass (Da):58,816
Last modified:November 1, 1998 - v1
Checksum:i531F68E0B72011C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015753 Genomic DNA Translation: BAA31703.1

Similar proteinsi

Entry informationi

Entry nameiO78728_9CEST
AccessioniPrimary (citable) accession number: O78728
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health