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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

MT-ND5

Organism
Carassius auratus (Goldfish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:MT-ND5
Synonyms:MTND5, NADH5, ND5
Encoded oniMitochondrion
OrganismiCarassius auratus (Goldfish)
Taxonomic identifieri7957 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei44 – 6421HelicalSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence analysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence analysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence analysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence analysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence analysisAdd
BLAST
Transmembranei406 – 42621HelicalSequence analysisAdd
BLAST
Transmembranei450 – 47021HelicalSequence analysisAdd
BLAST
Transmembranei490 – 51021HelicalSequence analysisAdd
BLAST
Transmembranei587 – 60721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607NADH-ubiquinone oxidoreductase chain 5PRO_0000118075Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

O78688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLIMHSSLL LIFFILMYPL LTTLNPNQQG SNMAGMTKTA VSSAFFISLL
60 70 80 90 100
PLMIFLNLKT EGIITNWQWM NTQTFDVNIS FKFDHYSLIF VPIALYVTWS
110 120 130 140 150
ILEFALWYMH SDPYIDRFFK YLLTFLVAMI ILVTANNMFQ LFIGWEGVGI
160 170 180 190 200
MSFLLIGWWH GRADANTAAL QAVIYNRVGD IGLIMTMAWF AMNLNSWEIQ
210 220 230 240 250
QIFVLSKNFD MTIPLMGLAL AATGKSAQFG LHPWLPSAME GPTPVSALLH
260 270 280 290 300
SSTMVVAGIF LLIRLHPLME NNQLALTTCL CLGALTSLFT ATCALTQNDI
310 320 330 340 350
KKIVAFSTSS QLGLMMVTIG LNQPQLAFLH ICTHAFFKAM LFLCSGSIIH
360 370 380 390 400
SLNDEQDIRK MGGLFSIMPA TSTYFTIGSL ALTGTPFLAG FFSKDAIIEA
410 420 430 440 450
LNTSHLNAWA LTLTLIATSF TAVYSFRLVY FVVMGTPRFL ALSPINENNP
460 470 480 490 500
LVINSIKRLA WGSIVAGLII TQNFLPMKTP IMTMPTTLKM AALLVTIAGL
510 520 530 540 550
LVAMELANMT SKQMKITPII PLHHFSNMLG FFPTIVHRLL PKLKLTLGQS
560 570 580 590 600
AATQLDKTWL EAMGPKGLAL TQMTMAKVTN DVSRGMIKTY LTIFLLTLIL

AILPVLL
Length:607
Mass (Da):67,313
Last modified:November 1, 1998 - v1
Checksum:iF791EB3DB060C199
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006953 Genomic DNA. Translation: BAA31248.1.
RefSeqiNP_008598.1. NC_002079.1.

Genome annotation databases

GeneIDi808419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006953 Genomic DNA. Translation: BAA31248.1.
RefSeqiNP_008598.1. NC_002079.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808419.

Organism-specific databases

CTDi4540.

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete sequence of mitochondrial genome from a gynogenetic triploid 'ginbuna' (Carassius auratus langsdorfi)."
    Murakami M., Yamashita Y., Fujitani H.
    Zool. Sci. 15:335-337(1998)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AZ3 / Langsdorfi.
    Tissue: Oocyte.

Entry informationi

Entry nameiNU5M_CARAU
AccessioniPrimary (citable) accession number: O78688
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 16, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.