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O78687 (NU4M_CARAU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded onMitochondrion
OrganismCarassius auratus (Goldfish)
Taxonomic identifier7957 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

Protein attributes

Sequence length460 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 460460NADH-ubiquinone oxidoreductase chain 4
PRO_0000117915

Regions

Transmembrane20 – 4223Helical; Potential
Transmembrane61 – 8121Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane195 – 21521Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane285 – 30420Helical; Potential
Transmembrane308 – 33023Helical; Potential
Transmembrane351 – 37121Helical; Potential
Transmembrane394 – 41421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O78687 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 3316E91DC0472A95

FASTA46051,554
        10         20         30         40         50         60 
MLKVLIPTIM LFPTIWLTSP KWLWTTTTAH SLLIASISLM WFKWTSETGW TSSNTYLATD 

        70         80         90        100        110        120 
PLSTPLLVLT CWLLPLMILA SQNHINPEPI SRQRLYITLL ASLQTFLIMA FGATEIIMFY 

       130        140        150        160        170        180 
IMFEATLIPT LIIITRWGNQ TERLNAGTYF LFYTLAGSLP LLVALLLLQQ STGTLSMLVL 

       190        200        210        220        230        240 
QYSQPLQLNS WGHMIWWAAC LIAFLVKMPL YGVHLWLPKA HVEAPVAGSM VLAAVLLKLG 

       250        260        270        280        290        300 
GYGMMRMMVM LDPLSKELAY PFIILALWGI IMTGSICLRQ TDLKSLIAYS SVSHMGLVAG 

       310        320        330        340        350        360 
GILIQTPWGF SGAIILMIAH GLVSSALFCL ANTAYERTHS RTMILARGLQ IIFPLTAVWW 

       370        380        390        400        410        420 
FIANLANLAL PPLPNLMGEL MIITTLFNWS PWTILLTGLG TLITAGYSLY MFLMSQRGPT 

       430        440        450        460 
PNHITGLQPF HTREHLLMTL HLIPVILLVT KPELMWGWCY 

« Hide

References

[1]"The complete sequence of mitochondrial genome from a gynogenetic triploid 'ginbuna' (Carassius auratus langsdorfi)."
Murakami M., Yamashita Y., Fujitani H.
Zool. Sci. 15:335-337(1998)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AZ3 / Langsdorfi.
Tissue: Oocyte.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006953 Genomic DNA. Translation: BAA31247.1.
RefSeqNP_008597.1. NC_002079.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808421.

Organism-specific databases

CTD4538.

Phylogenomic databases

HOVERGENHBG093667.
ProtClustDBMTH00127.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4M_CARAU
AccessionPrimary (citable) accession number: O78687
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families