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O78687

- NU4M_CARAU

UniProt

O78687 - NU4M_CARAU

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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Carassius auratus (Goldfish)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiCarassius auratus (Goldfish)
Taxonomic identifieri7957 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460NADH-ubiquinone oxidoreductase chain 4PRO_0000117915Add
BLAST

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4223HelicalSequence AnalysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence AnalysisAdd
BLAST
Transmembranei285 – 30420HelicalSequence AnalysisAdd
BLAST
Transmembranei308 – 33023HelicalSequence AnalysisAdd
BLAST
Transmembranei351 – 37121HelicalSequence AnalysisAdd
BLAST
Transmembranei394 – 41421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O78687-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKVLIPTIM LFPTIWLTSP KWLWTTTTAH SLLIASISLM WFKWTSETGW
60 70 80 90 100
TSSNTYLATD PLSTPLLVLT CWLLPLMILA SQNHINPEPI SRQRLYITLL
110 120 130 140 150
ASLQTFLIMA FGATEIIMFY IMFEATLIPT LIIITRWGNQ TERLNAGTYF
160 170 180 190 200
LFYTLAGSLP LLVALLLLQQ STGTLSMLVL QYSQPLQLNS WGHMIWWAAC
210 220 230 240 250
LIAFLVKMPL YGVHLWLPKA HVEAPVAGSM VLAAVLLKLG GYGMMRMMVM
260 270 280 290 300
LDPLSKELAY PFIILALWGI IMTGSICLRQ TDLKSLIAYS SVSHMGLVAG
310 320 330 340 350
GILIQTPWGF SGAIILMIAH GLVSSALFCL ANTAYERTHS RTMILARGLQ
360 370 380 390 400
IIFPLTAVWW FIANLANLAL PPLPNLMGEL MIITTLFNWS PWTILLTGLG
410 420 430 440 450
TLITAGYSLY MFLMSQRGPT PNHITGLQPF HTREHLLMTL HLIPVILLVT
460
KPELMWGWCY
Length:460
Mass (Da):51,554
Last modified:November 1, 1998 - v1
Checksum:i3316E91DC0472A95
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006953 Genomic DNA. Translation: BAA31247.1.
RefSeqiNP_008597.1. NC_002079.1.

Genome annotation databases

GeneIDi808421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006953 Genomic DNA. Translation: BAA31247.1 .
RefSeqi NP_008597.1. NC_002079.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808421.

Organism-specific databases

CTDi 4538.

Phylogenomic databases

HOVERGENi HBG093667.

Family and domain databases

InterProi IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view ]
PRINTSi PR01437. NUOXDRDTASE4.
TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete sequence of mitochondrial genome from a gynogenetic triploid 'ginbuna' (Carassius auratus langsdorfi)."
    Murakami M., Yamashita Y., Fujitani H.
    Zool. Sci. 15:335-337(1998)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AZ3 / Langsdorfi.
    Tissue: Oocyte.

Entry informationi

Entry nameiNU4M_CARAU
AccessioniPrimary (citable) accession number: O78687
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3