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O78497

- HO_GUITH

UniProt

O78497 - HO_GUITH

Protein

Heme oxygenase

Gene

pbsA

Organism
Guillardia theta (Cryptomonas phi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae.

    Catalytic activityi

    Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi17 – 171Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme oxygenase (decyclizing) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. heme oxidation Source: InterPro
    2. photosynthesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Photosynthesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heme oxygenase (EC:1.14.99.3)
    Gene namesi
    Name:pbsA
    Encoded oniPlastid; Chloroplast
    OrganismiGuillardia theta (Cryptomonas phi)
    Taxonomic identifieri55529 [NCBI]
    Taxonomic lineageiEukaryotaCryptophytaPyrenomonadalesGeminigeraceaeGuillardia

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 237237Heme oxygenasePRO_0000209698Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO78497.
    SMRiO78497. Positions 2-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heme oxygenase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000233221.
    OMAiMDRNKDH.

    Family and domain databases

    Gene3Di1.20.910.10. 1 hit.
    InterProiIPR002051. Haem_Oase.
    IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR018207. Haem_oxygenase_CS.
    [Graphical view]
    PANTHERiPTHR10720. PTHR10720. 1 hit.
    PfamiPF01126. Heme_oxygenase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000343. Haem_Oase. 1 hit.
    PRINTSiPR00088. HAEMOXYGNASE.
    SUPFAMiSSF48613. SSF48613. 1 hit.
    PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O78497-1 [UniParc]FASTAAdd to Basket

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    MSNNLAIQLR EGTSKSHSMA ENVSFVKSFL SGVIDTNSYK KMMSNLYFVY    50
    KAMEEEMEYH KENDLIKPIY FVELNRSESL ALDLNFYYGD TWKDIIEPSE 100
    ATRVYINRIK KISKEKPLLL IAHAYTRYLG DLSGGQILKK IAQRALNVPN 150
    SQGLAFYEFD KIDDEQAFKQ KYKKALDTLP VTDKMISQIV AEANIAFNLN 200
    MRMFQELEMS YIRIFTKILM QFLINSKDKL RVMLNFS 237
    Length:237
    Mass (Da):27,631
    Last modified:November 1, 1998 - v1
    Checksum:iCBDD4D045A7B8890
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041468 Genomic DNA. Translation: AAC35688.1.
    RefSeqiNP_050754.1. NC_000926.1.

    Genome annotation databases

    GeneIDi857059.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041468 Genomic DNA. Translation: AAC35688.1 .
    RefSeqi NP_050754.1. NC_000926.1.

    3D structure databases

    ProteinModelPortali O78497.
    SMRi O78497. Positions 2-218.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 857059.

    Phylogenomic databases

    HOGENOMi HOG000233221.
    OMAi MDRNKDH.

    Family and domain databases

    Gene3Di 1.20.910.10. 1 hit.
    InterProi IPR002051. Haem_Oase.
    IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR018207. Haem_oxygenase_CS.
    [Graphical view ]
    PANTHERi PTHR10720. PTHR10720. 1 hit.
    Pfami PF01126. Heme_oxygenase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000343. Haem_Oase. 1 hit.
    PRINTSi PR00088. HAEMOXYGNASE.
    SUPFAMi SSF48613. SSF48613. 1 hit.
    PROSITEi PS00593. HEME_OXYGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The plastid genome of the cryptophyte alga, Guillardia theta: complete sequence and conserved synteny groups confirm its common ancestry with red algae."
      Douglas S.E., Penny S.L.
      J. Mol. Evol. 48:236-244(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiHO_GUITH
    AccessioniPrimary (citable) accession number: O78497
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3