O78497 (HO_GUITH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heme oxygenase
EC=1.14.99.3

Gene names

Name:

pbsA

Encoded on

Plastid; Chloroplast

Organism

Guillardia theta (Cryptomonas phi)

Taxonomic identifier

55529 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Cryptophyta › Pyrenomonadales › Geminigeraceae › Guillardia

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae.
Catalytic activity	Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.
Subcellular location	Plastid › chloroplast.
Sequence similarities	Belongs to the heme oxygenase family.

Ontologies

Keywords
Biological process	Photosynthesis
Cellular component	Chloroplast Plastid
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	heme oxidation Inferred from electronic annotation. Source: InterPro photosynthesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	heme oxygenase (decyclizing) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	Heme oxygenase		PRO_0000209698
Sites
	Metal binding	17	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O78497 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: CBDD4D045A7B8890	FASTA	237	27,631
	10 20 30 40 50 60 MSNNLAIQLR EGTSKSHSMA ENVSFVKSFL SGVIDTNSYK KMMSNLYFVY KAMEEEMEYH 70 80 90 100 110 120 KENDLIKPIY FVELNRSESL ALDLNFYYGD TWKDIIEPSE ATRVYINRIK KISKEKPLLL 130 140 150 160 170 180 IAHAYTRYLG DLSGGQILKK IAQRALNVPN SQGLAFYEFD KIDDEQAFKQ KYKKALDTLP 190 200 210 220 230 VTDKMISQIV AEANIAFNLN MRMFQELEMS YIRIFTKILM QFLINSKDKL RVMLNFS

References

[1]

"The plastid genome of the cryptophyte alga, Guillardia theta: complete sequence and conserved synteny groups confirm its common ancestry with red algae." Douglas S.E., Penny S.L. J. Mol. Evol. 48:236-244(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF041468 Genomic DNA. Translation: AAC35688.1.
RefSeq	NP_050754.1. NC_000926.1.
3D structure databases
ProteinModelPortal	O78497.
SMR	O78497. Positions 2-218.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	857059.
Phylogenomic databases
HOGENOM	HOG000233221.
OMA	KQFYRAR.
ProtClustDB	CHL00168.
Family and domain databases
Gene3D	1.20.910.10. 1 hit.
InterPro	IPR002051. Haem_Oase. IPR016053. Haem_Oase-like. IPR016084. Haem_Oase-like_multi-hlx. IPR018207. Haem_oxygenase_CS. [Graphical view]
PANTHER	PTHR10720. PTHR10720. 1 hit.
Pfam	PF01126. Heme_oxygenase. 1 hit. [Graphical view]
PIRSF	PIRSF000343. Haem_Oase. 1 hit.
PRINTS	PR00088. HAEMOXYGNASE.
SUPFAM	SSF48613. Heme_oxygenase. 1 hit.
PROSITE	PS00593. HEME_OXYGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HO_GUITH

Accession

Primary (citable) accession number: O78497

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)