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O78497 (HO_GUITH) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heme oxygenase

EC=1.14.99.3
Gene names
Name:pbsA
Encoded onPlastid; Chloroplast
OrganismGuillardia theta (Cryptomonas phi)
Taxonomic identifier55529 [NCBI]
Taxonomic lineageEukaryotaCryptophytaPyrenomonadalesGeminigeraceaeGuillardia

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae.

Catalytic activity

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

Subcellular location

Plastidchloroplast.

Sequence similarities

Belongs to the heme oxygenase family.

Ontologies

Keywords
   Biological processPhotosynthesis
   Cellular componentChloroplast
Plastid
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processheme oxidation

Inferred from electronic annotation. Source: InterPro

photosynthesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionheme oxygenase (decyclizing) activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237Heme oxygenase
PRO_0000209698

Sites

Metal binding171Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O78497 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: CBDD4D045A7B8890

FASTA23727,631
        10         20         30         40         50         60 
MSNNLAIQLR EGTSKSHSMA ENVSFVKSFL SGVIDTNSYK KMMSNLYFVY KAMEEEMEYH 

        70         80         90        100        110        120 
KENDLIKPIY FVELNRSESL ALDLNFYYGD TWKDIIEPSE ATRVYINRIK KISKEKPLLL 

       130        140        150        160        170        180 
IAHAYTRYLG DLSGGQILKK IAQRALNVPN SQGLAFYEFD KIDDEQAFKQ KYKKALDTLP 

       190        200        210        220        230 
VTDKMISQIV AEANIAFNLN MRMFQELEMS YIRIFTKILM QFLINSKDKL RVMLNFS 

« Hide

References

[1]"The plastid genome of the cryptophyte alga, Guillardia theta: complete sequence and conserved synteny groups confirm its common ancestry with red algae."
Douglas S.E., Penny S.L.
J. Mol. Evol. 48:236-244(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF041468 Genomic DNA. Translation: AAC35688.1.
RefSeqNP_050754.1. NC_000926.1.

3D structure databases

ProteinModelPortalO78497.
SMRO78497. Positions 2-218.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID857059.

Phylogenomic databases

HOGENOMHOG000233221.
OMAKKSHTMA.
ProtClustDBCHL00168.

Family and domain databases

Gene3D1.20.910.10. 1 hit.
InterProIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERPTHR10720. PTHR10720. 1 hit.
PfamPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFPIRSF000343. Haem_Oase. 1 hit.
PRINTSPR00088. HAEMOXYGNASE.
SUPFAMSSF48613. SSF48613. 1 hit.
PROSITEPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHO_GUITH
AccessionPrimary (citable) accession number: O78497
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: October 16, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families