Reviewed, UniProtKB/Swiss-Prot O78310 (SODCP_ARATH)

Names and origin

Protein names

Recommended name:
    Superoxide dismutase [Cu-Zn], chloroplastic
    EC=1.15.1.1

Gene names

Name:	SODCP
Synonyms:	CSD2
Ordered Locus Names:	At2g28190
ORF Names:	F24D13.2

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Plastid › chloroplast.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to copper ion Inferred from expression pattern. Source: TAIR response to iron ion Inferred from expression pattern. Source: TAIR response to oxidative stress Inferred from direct assay. Source: TAIR superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	apoplast Inferred from direct assay. Source: TAIR chloroplast stroma Inferred from direct assay. Source: TAIR thylakoid Inferred from direct assay. Source: TAIR
Molecular function	antioxidant activity Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 62	62	Chloroplast
	Chain	63 – 216	154	Superoxide dismutase [Cu-Zn], chloroplastic		PRO_0000032844
Sites
	Metal binding	108	1	Copper; catalytic By similarity
	Metal binding	110	1	Copper; catalytic By similarity
	Metal binding	125	1	Copper; catalytic By similarity
	Metal binding	125	1	Zinc; structural By similarity
	Metal binding	133	1	Zinc; structural By similarity
	Metal binding	142	1	Zinc; structural By similarity
	Metal binding	145	1	Zinc; structural By similarity
	Metal binding	182	1	Copper; catalytic By similarity
Amino acid modifications
	Disulfide bond	119 ↔ 208		By similarity
Experimental info
	Sequence conflict	32	1	R → S in AAD10208. Ref.1
	Sequence conflict	32	1	R → S in AAM65492. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	O78310-1 [UniParc]. Last modified June 20, 2002. Version 2. Checksum: 5F0E4333E1C1581C	FASTA	216	22,244
	10 20 30 40 50 60 MAATNTILAF SSPSRLLIPP SSNPSTLRSS FRGVSLNNNN LHRLQSVSFA VKAPSKALTV 70 80 90 100 110 120 VSAAKKAVAV LKGTSDVEGV VTLTQDDSGP TTVNVRITGL TPGPHGFHLH EFGDTTNGCI 130 140 150 160 170 180 STGPHFNPNN MTHGAPEDEC RHAGDLGNIN ANADGVAETT IVDNQIPLTG PNSVVGRAFV 190 200 210 VHELKDDLGK GGHELSLTTG NAGGRLACGV IGLTPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Superoxide dismutase in Arabidopsis: an eclectic enzyme family with disparate regulation and protein localization." Kliebenstein D.J., Monde R.A., Last R.L. Plant Physiol. 118:637-650(1998) [PubMed: 9765550] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia.
[2]	"Two genomic sequences encoding chloroplastic Cu/Zn superoxide dismutases from Arabidopsis thaliana ecotypes Ler and Cvi." Abarca D., Martin M., Sabater B. Plant Gene Register PGR99-089 Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. Landsberg erecta.
[3]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[4]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[5]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF061519 mRNA. Translation: AAD10208.1. AJ238521 Genomic DNA. Translation: CAB51839.1. AC005851 Genomic DNA. Translation: AAM15088.1. AY064050 mRNA. Translation: AAL36406.1. AY133756 mRNA. Translation: AAM91690.1. AY087944 mRNA. Translation: AAM65492.1.
IPI	IPI00520632.
PIR	T51730.
RefSeq	NP_565666.1.
UniGene	At.20409
3D structure databases
HSSP	HSSP built from PDB template 1SRD based on UniProtKB P07505.
SMR	O78310. Positions 63-216.
ModBase	Search...
Protein-protein interaction databases
STRING	O78310.
Proteomic databases
PRIDE	O78310.
ProMEX	O78310.
Genome annotation databases
GeneID	817365.
GenomeReviews	Gene locus AT2G28190 in contig CT485783_GR.
KEGG	ath:AT2G28190.
Organism-specific databases
TAIR	At2g28190.
Phylogenomic databases
OMA	GPHFNPN.
Enzyme and pathway databases
BRENDA	1.15.1.1. 302.
Gene expression databases
ArrayExpress	O78310.
Genevestigator	O78310.
GermOnline	AT2G28190. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn. [Graphical view]
Gene3D	G3DSA:2.60.40.200. SOD_Cu_Zn. 1 hit.
PANTHER	PTHR10003. SOD_Cu_Zn. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
ProDom	PD000469. SOD_CU_ZN. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODCP_ARATH

Accession

Primary (citable) accession number: O78310
Secondary accession number(s): Q541D5, Q9SUJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	June 20, 2002
Last modified:	November 3, 2009
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)