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Protein

Superoxide dismutase [Cu-Zn] 2, chloroplastic

Gene

CSD2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Mediates tolerance to stress, including photo-oxidative stress.3 Publications

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi108Copper; catalyticBy similarity1
Metal bindingi110Copper; catalyticBy similarity1
Metal bindingi125Copper; catalyticBy similarity1
Metal bindingi125Zinc; structuralBy similarity1
Metal bindingi133Zinc; structuralBy similarity1
Metal bindingi142Zinc; structuralBy similarity1
Metal bindingi145Zinc; structuralBy similarity1
Metal bindingi182Copper; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular response to light intensity Source: UniProtKB
  • cellular response to oxidative stress Source: UniProtKB
  • cellular response to ozone Source: UniProtKB
  • cellular response to salt stress Source: UniProtKB
  • cellular response to sucrose stimulus Source: UniProtKB
  • cellular response to UV-B Source: UniProtKB
  • gene silencing by miRNA Source: UniProtKB
  • response to copper ion Source: TAIR
  • response to iron ion Source: TAIR
  • response to oxidative stress Source: TAIR

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandCopper, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-ATH-114608 Platelet degranulation
R-ATH-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] 2, chloroplastic (EC:1.15.1.1)
Alternative name(s):
Copper/zinc superoxide dismutase 2
Gene namesi
Name:CSD2
Synonyms:KD-SOD, SODCP
Ordered Locus Names:At2g28190
ORF Names:F24D13.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G28190
TAIRilocus:2046168 AT2G28190

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

Pathology & Biotechi

Disruption phenotypei

Growth retardation (e.g. delayed flowering) and abnormal chloroplasts (e.g. less organized with fewer stacks). This phenotype is reversed under very low light conditions. Enhanced tolerance to oxidative stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 62ChloroplastAdd BLAST62
ChainiPRO_000003284463 – 216Superoxide dismutase [Cu-Zn] 2, chloroplasticAdd BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi119 ↔ 208By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO78310
PRIDEiO78310

PTM databases

iPTMnetiO78310

Expressioni

Tissue specificityi

Expressed in leaves (at protein level). The spatial localization is regulated by miR398-mediated silencing. Mostly present in flowers, old rosette leaves and inflorescence, and, to a lower extent, in cauline leaves, stems and roots.2 Publications

Inductioni

Upon photosynthetically active radiation (PAR) (e.g. light fluence) increase and UV-B treatment. Accumulates in response to ozone fumigation, during recovery. Induced in response to oxidative stress, via a reduction of miR398-mediated silencing. Repressed by sucrose in a miR398-mediated silencing-dependent manner. Repressed by salt stress. Down-regulated by aconitase.4 Publications

Gene expression databases

ExpressionAtlasiO78310 baseline and differential
GenevisibleiO78310 AT

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi2715, 2 interactors
IntActiO78310, 1 interactor
STRINGi3702.AT2G28190.1

Structurei

3D structure databases

ProteinModelPortaliO78310
SMRiO78310
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0441 Eukaryota
COG2032 LUCA
HOGENOMiHOG000263447
InParanoidiO78310
KOiK04565
OMAiIHTFGDN
OrthoDBiEOG09360OJH
PhylomeDBiO78310

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
PRINTSiPR00068 CUZNDISMTASE
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00087 SOD_CU_ZN_1, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O78310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATNTILAF SSPSRLLIPP SSNPSTLRSS FRGVSLNNNN LHRLQSVSFA
60 70 80 90 100
VKAPSKALTV VSAAKKAVAV LKGTSDVEGV VTLTQDDSGP TTVNVRITGL
110 120 130 140 150
TPGPHGFHLH EFGDTTNGCI STGPHFNPNN MTHGAPEDEC RHAGDLGNIN
160 170 180 190 200
ANADGVAETT IVDNQIPLTG PNSVVGRAFV VHELKDDLGK GGHELSLTTG
210
NAGGRLACGV IGLTPL
Length:216
Mass (Da):22,244
Last modified:June 20, 2002 - v2
Checksum:i5F0E4333E1C1581C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32R → S in AAD10208 (PubMed:9765550).Curated1
Sequence conflicti32R → S in AAM65492 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti23N → Y in strain: cv. Cvi-1; enhanced stability and better tolerance to photo-oxidative stress conditions; when associated with S-39, A-101 and K-164. 1 Publication1
Natural varianti39N → S in strain: cv. Cvi-1; enhanced stability and better tolerance to photo-oxidative stress conditions; when associated with Y-23, A-101 and K-164. 1 Publication1
Natural varianti101T → A in strain: cv. Cvi-1; enhanced stability and better tolerance to photo-oxidative stress conditions; when associated with Y-23, S-39 and K-164. 1 Publication1
Natural varianti164N → K in strain: cv. Cvi-1; enhanced stability and better tolerance to photo-oxidative stress conditions; when associated with Y-23, S-39 and A-101. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061519 mRNA Translation: AAD10208.1
AJ238521 Genomic DNA Translation: CAB51839.1
AJ238522 Genomic DNA Translation: CAB51840.1
AC005851 Genomic DNA Translation: AAM15088.1
CP002685 Genomic DNA Translation: AEC08089.1
AY064050 mRNA Translation: AAL36406.1
AY133756 mRNA Translation: AAM91690.1
AK227096 mRNA Translation: BAE99148.1
AY087944 mRNA Translation: AAM65492.1
PIRiT51730
RefSeqiNP_565666.1, NM_128379.4
UniGeneiAt.20409

Genome annotation databases

EnsemblPlantsiAT2G28190.1; AT2G28190.1; AT2G28190
GeneIDi817365
GrameneiAT2G28190.1; AT2G28190.1; AT2G28190
KEGGiath:AT2G28190

Similar proteinsi

Entry informationi

Entry nameiSODC2_ARATH
AccessioniPrimary (citable) accession number: O78310
Secondary accession number(s): Q0WUQ0
, Q541D5, Q9SUJ7, Q9SUJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 20, 2002
Last modified: April 25, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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